{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T14:54:04Z","timestamp":1776524044780,"version":"3.51.2"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002345","name":"University of T\u00fcbingen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["INST 37\/935-1 FUGG"],"award-info":[{"award-number":["INST 37\/935-1 FUGG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009139","name":"German Center for Infection Research","doi-asserted-by":"publisher","award":["DZIF TTU09.716"],"award-info":[{"award-number":["DZIF TTU09.716"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF20CC0035580"],"award-info":[{"award-number":["NNF20CC0035580"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF16OC0021746"],"award-info":[{"award-number":["NNF16OC0021746"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>As a result of the continuous evolution of drug resistant bacteria, new antibiotics are urgently needed. Encoded by biosynthetic gene clusters (BGCs), antibiotic compounds are mostly produced by bacteria. With the exponential increase in the number of publicly available, sequenced genomes and the advancements of BGC prediction tools, genome mining algorithms have uncovered millions of uncharacterized BGCs for further evaluation. Since compound identification and characterization remain bottlenecks, a major challenge is prioritizing promising BGCs. Recently, researchers adopted self-resistance based strategies allowing them to predict the biological activities of natural products encoded by uncharacterized BGCs. Since 2017, the Antibiotic Resistant Target Seeker (ARTS) facilitated this so-called target-directed genome mining (TDGM) approach for the prioritization of BGCs encoding potentially novel antibiotics. Here, we present the ARTS database, available at https:\/\/arts-db.ziemertlab.com\/. The ARTS database provides pre-computed ARTS results for &amp;gt;70,000 genomes and metagenome assembled genomes in total. Advanced search queries allow users to rapidly explore the fundamental criteria of TDGM such as BGC proximity, duplication and horizontal gene transfers of essential housekeeping genes. Furthermore, the ARTS database provides results interconnected throughout the bacterial kingdom as well as links to known databases in natural product research.<\/jats:p>","DOI":"10.1093\/nar\/gkab940","type":"journal-article","created":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T07:38:27Z","timestamp":1633160307000},"page":"D736-D740","source":"Crossref","is-referenced-by-count":26,"title":["ARTS-DB: a database for antibiotic resistant targets"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5603-9890","authenticated-orcid":false,"given":"Mehmet Diren\u00e7","family":"Mungan","sequence":"first","affiliation":[{"name":"Interfaculty Institute of Microbiology and Infection Medicine, Institute for Bioinformatics and Medical Informatics, University of T\u00fcbingen, 72076 T\u00fcbingen, Germany"},{"name":"German Center for Infection Research (DZIF), Partner Site T\u00fcbingen, 72076 T\u00fcbingen,\u00a0Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3764-6051","authenticated-orcid":false,"given":"Kai","family":"Blin","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet Bygning 220, 2800 Kgs. Lyngby, Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7264-1857","authenticated-orcid":false,"given":"Nadine","family":"Ziemert","sequence":"additional","affiliation":[{"name":"Interfaculty Institute of Microbiology and Infection Medicine, Institute for Bioinformatics and Medical Informatics, University of T\u00fcbingen, 72076 T\u00fcbingen, Germany"},{"name":"German Center for Infection Research (DZIF), Partner Site T\u00fcbingen, 72076 T\u00fcbingen,\u00a0Germany"}]}],"member":"286","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"2022010507370175200_B1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd4510","article-title":"The re-emergence of natural products for drug discovery in the genomics era","volume":"14","author":"Harvey","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"2022010507370175200_B2","doi-asserted-by":"crossref","first-page":"e1035","DOI":"10.1002\/mbo3.1035","article-title":"The incidence of antibiotic resistance within and beyond the agricultural ecosystem: a concern for public health","volume":"9","author":"Iwu","year":"2020","journal-title":"Microbiologyopen"},{"key":"2022010507370175200_B3","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"2022010507370175200_B4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"2022010507370175200_B5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev-micro-012420-081224","article-title":"Chemical mediators at the bacterial-fungal interface","volume":"74","author":"Scherlach","year":"2020","journal-title":"Annu. Rev. Microbiol."},{"key":"2022010507370175200_B6","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1039\/C6NP00025H","article-title":"The evolution of genome mining in microbes\u2013a review","volume":"33","author":"Ziemert","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"2022010507370175200_B7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-24133-5","article-title":"Mining and unearthing hidden biosynthetic potential","volume":"12","author":"Scherlach","year":"2021","journal-title":"Nat. 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Biot."},{"key":"2022010507370175200_B13","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1039\/C9NP00050J","article-title":"Recent developments in self-resistance gene directed natural product discovery","volume":"37","author":"Yan","year":"2020","journal-title":"Nat. Prod. Rep."},{"key":"2022010507370175200_B14","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1128\/AAC.00448-13","article-title":"Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase","volume":"57","author":"Atkinson","year":"2013","journal-title":"Antimicrob. Agents Ch."},{"key":"2022010507370175200_B15","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1021\/acschembio.8b00173","article-title":"Self-resistance of natural product producers: past, present, and future focusing on self-resistant protein variants","volume":"13","author":"Almabruk","year":"2018","journal-title":"ACS Chem. 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