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Therefore, a devoted resource of sequence compositions and associated features is fundamentally crucial for a wide range of biological research. Here, we present CompoDynamics (https:\/\/ngdc.cncb.ac.cn\/compodynamics\/), a comprehensive database of sequence compositions of coding sequences (CDSs) and genomes for all kinds of species. Taking advantage of the exponential growth of RefSeq data, CompoDynamics presents a wealth of sequence compositions (nucleotide content, codon usage, amino acid usage) and derived features (coding potential, physicochemical property and phase separation) for 118 689 747 high-quality CDSs and 34 562 genomes across 24 995 species. Additionally, interactive analytical tools are provided to enable comparative analyses of sequence compositions and molecular features across different species and gene groups. Collectively, CompoDynamics bears the great potential to better understand the underlying roles of sequence composition dynamics across genes and genomes, providing a fundamental resource in support of a broad spectrum of biological studies.<\/jats:p>","DOI":"10.1093\/nar\/gkab979","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T12:21:32Z","timestamp":1633609292000},"page":"D962-D969","source":"Crossref","is-referenced-by-count":6,"title":["CompoDynamics: a comprehensive database for characterizing sequence composition dynamics"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6722-176X","authenticated-orcid":false,"given":"Shuai","family":"Jiang","sequence":"first","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3121-2327","authenticated-orcid":false,"given":"Qiang","family":"Du","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2024-8575","authenticated-orcid":false,"given":"Changrui","family":"Feng","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6390-6289","authenticated-orcid":false,"given":"Lina","family":"Ma","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6603-5060","authenticated-orcid":false,"given":"Zhang","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"China National Center for Bioinformation, Beijing 100101, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}]}],"member":"286","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"key":"2022010507361971500_B1","doi-asserted-by":"crossref","first-page":"646300","DOI":"10.3389\/fmicb.2021.646300","article-title":"Nucleotide composition and codon usage across viruses and their respective hosts","volume":"12","author":"Simon","year":"2021","journal-title":"Front Microbiol"},{"key":"2022010507361971500_B2","doi-asserted-by":"crossref","first-page":"e1004941","DOI":"10.1371\/journal.pgen.1004941","article-title":"GC-Content evolution in bacterial genomes: the biased gene conversion hypothesis expands","volume":"11","author":"Lassalle","year":"2015","journal-title":"PLoS Genet."},{"key":"2022010507361971500_B3","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/gbe\/evs052","article-title":"Evidence for widespread GC-biased gene conversion in eukaryotes","volume":"4","author":"Pessia","year":"2012","journal-title":"Genome Biol Evol"},{"key":"2022010507361971500_B4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1745-6150-7-2","article-title":"On the molecular mechanism of GC content variation among eubacterial genomes","volume":"7","author":"Wu","year":"2012","journal-title":"Biol. 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