{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:27:22Z","timestamp":1758709642611,"version":"3.37.3"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"D1","funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["HHSN31620120054W","HHSN273201000063U GS06F0629Z"],"award-info":[{"award-number":["HHSN31620120054W","HHSN273201000063U GS06F0629Z"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The Chemical Effects in Biological Systems database (CEBS) contains extensive toxicology study results and metadata from the Division of the National Toxicology Program (NTP) and other studies of environmental health interest. This resource grants public access to search and collate data from over 10 250 studies for 12 750 test articles (chemicals, environmental agents). CEBS has made considerable strides over the last 5 years to integrate growing internal data repositories into data warehouses and data marts to better serve the public with high quality curated datasets. This effort includes harmonizing legacy terms and metadata to current standards, mapping test articles to external identifiers, and aligning terms to OBO (Open Biological and Biomedical Ontology) Foundry ontologies. The data are made available through the CEBS Homepage (https:\/\/cebs.niehs.nih.gov\/cebs\/), guided search applications, flat files on FTP (file transfer protocol), and APIs (application programming interface) for user access and to provide a bridge for computational tools. The user interface is intuitive with a single search bar to query keywords related to study metadata, publications, and data availability. Results are consolidated to single pages for each test article with NTP conclusions, publications, individual studies, data collections, and links to related test articles and projects available together.<\/jats:p>","DOI":"10.1093\/nar\/gkab981","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T20:13:01Z","timestamp":1635797581000},"page":"D1156-D1163","source":"Crossref","is-referenced-by-count":5,"title":["CEBS update: curated toxicology database with enhanced tools for data integration"],"prefix":"10.1093","volume":"50","author":[{"given":"Cari","family":"Martini","sequence":"first","affiliation":[{"name":"ASRC Federal, 430 Davis Dr., Suite 400, Morrisville, NC 27560, USA"}]},{"given":"Ying Frances","family":"Liu","sequence":"additional","affiliation":[{"name":"ASRC Federal, 430 Davis Dr., Suite 400, Morrisville, NC 27560, USA"}]},{"given":"Hui","family":"Gong","sequence":"additional","affiliation":[{"name":"ASRC Federal, 430 Davis Dr., Suite 400, Morrisville, NC 27560, USA"}]},{"given":"Nicole","family":"Sayers","sequence":"additional","affiliation":[{"name":"ASRC Federal, 430 Davis Dr., Suite 400, Morrisville, NC 27560, USA"}]},{"given":"German","family":"Segura","sequence":"additional","affiliation":[{"name":"ASRC Federal, 430 Davis Dr., Suite 400, Morrisville, NC 27560, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5858-4393","authenticated-orcid":false,"given":"Jennifer","family":"Fostel","sequence":"additional","affiliation":[{"name":"Division of the National Toxicology Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA"}]}],"member":"286","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"2022010507361152000_B1","first-page":"15","article-title":"Systems toxicology and the Chemical Effects in Biological Systems (CEBS) knowledge base","volume":"111","author":"Waters","year":"2003","journal-title":"EHP Toxicogenomics"},{"key":"2022010507361152000_B2","doi-asserted-by":"crossref","first-page":"D892","DOI":"10.1093\/nar\/gkm755","article-title":"CEBS\u2014chemical effects in biological systems: a public data repository integrating study design and toxicity data with microarray and proteomics data","volume":"36","author":"Waters","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2022010507361152000_B3","doi-asserted-by":"crossref","first-page":"D964","DOI":"10.1093\/nar\/gkw1077","article-title":"CEBS: a comprehensive annotated database of toxicological data","volume":"45","author":"Lea","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2022010507361152000_B4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jbiotec.2005.03.022","article-title":"Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action","volume":"119","author":"Ganter","year":"2005","journal-title":"J. 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