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The database now contains over 35 000 alleles of the human Major Histocompatibility Complex (MHC) named by the WHO Nomenclature Committee for Factors of the HLA System. This complex contains the most polymorphic genes in the human genome and is now considered hyperpolymorphic. The IPD-IMGT\/HLA Database provides a stable and user-friendly repository for this information. Uptake of Next Generation Sequencing technology in recent years has driven an increase in the number of alleles and the length of sequences submitted. As the size of the database has grown the traditional methods of accessing and presenting this data have been challenged, in response, we have developed a suite of tools providing an enhanced user experience to our traditional web-based users while creating new programmatic access for our bioinformatics user base. This suite of tools is powered by the IPD-API, an Application Programming Interface (API), providing scalable and flexible access to the database. The IPD-API provides a stable platform for our future development allowing us to meet the future challenges of the HLA field and needs of the community.<\/jats:p>","DOI":"10.1093\/nar\/gkac1011","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T16:34:20Z","timestamp":1668011660000},"page":"D1053-D1060","source":"Crossref","is-referenced-by-count":1463,"title":["The IPD-IMGT\/HLA Database"],"prefix":"10.1093","volume":"51","author":[{"given":"Dominic J","family":"Barker","sequence":"first","affiliation":[{"name":"Anthony Nolan Research Institute , Royal Free Hospital, Pond Street ,\u00a0 London ,\u00a0 NW3 2QG , UK"},{"name":"UCL Cancer Institute, University College London (UCL) , Royal Free Campus, Pond Street , London ,\u00a0 NW3 2QG ,\u00a0 UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Maccari","sequence":"additional","affiliation":[{"name":"Data Science for Health (DaScH) Lab, Fondazione Toscana Life Sciences ,\u00a0 Siena ,\u00a0 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenia","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Anthony Nolan Research Institute , Royal Free Hospital, Pond Street ,\u00a0 London ,\u00a0 NW3 2QG , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Cooper","sequence":"additional","affiliation":[{"name":"Anthony Nolan Research Institute , Royal Free Hospital, Pond Street ,\u00a0 London ,\u00a0 NW3 2QG , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3897-7955","authenticated-orcid":false,"given":"Paul","family":"Flicek","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) , Wellcome Genome Campus , Hinxton ,\u00a0 Cambridge ,\u00a0 CB10 1SD , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2187-5944","authenticated-orcid":false,"given":"James","family":"Robinson","sequence":"additional","affiliation":[{"name":"Anthony Nolan Research Institute , Royal Free Hospital, Pond Street ,\u00a0 London ,\u00a0 NW3 2QG , UK"},{"name":"UCL Cancer Institute, University College London (UCL) , Royal Free Campus, Pond Street , London ,\u00a0 NW3 2QG ,\u00a0 UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2855-4120","authenticated-orcid":false,"given":"Steven G E","family":"Marsh","sequence":"additional","affiliation":[{"name":"Anthony Nolan Research Institute , Royal Free Hospital, Pond Street ,\u00a0 London ,\u00a0 NW3 2QG , UK"},{"name":"UCL Cancer Institute, University College London (UCL) , Royal Free Campus, Pond Street , London ,\u00a0 NW3 2QG ,\u00a0 UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"2023010804173095100_B1","first-page":"17","article-title":"Development of the international immunogenetics HLA database","volume":"59","author":"Robinson","year":"1998","journal-title":"Hum. 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