{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:40:29Z","timestamp":1777164029679,"version":"3.51.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R313-2019-526"],"award-info":[{"award-number":["R313-2019-526"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF18OC0031226"],"award-info":[{"award-number":["NNF18OC0031226"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"publisher","award":["NAP3.0"],"award-info":[{"award-number":["NAP3.0"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>G protein-coupled receptors (GPCRs) are physiologically abundant signaling hubs routing hundreds of extracellular signal substances and drugs into intracellular pathways. The GPCR database, GPCRdb supports\u00a0&amp;gt;5000 interdisciplinary researchers every month with reference data, analysis, visualization, experiment design and dissemination. Here, we present our fifth major GPCRdb release setting out with an overview of the many resources for receptor sequences, structures, and ligands. This includes recently published additions of class D generic residue numbers, a comparative structure analysis tool to identify functional determinants, trees clustering GPCR structures by 3D conformation, and mutations stabilizing inactive\/active states. We provide new state-specific structure models of all human non-olfactory GPCRs built using AlphaFold2-MultiState. We also provide a new resource of endogenous ligands along with a larger number of surrogate ligands with bioactivity, vendor, and physiochemical descriptor data. The one-stop-shop ligand resources integrate ligands\/data from the ChEMBL, Guide to Pharmacology, PDSP Ki\u00a0and PubChem database. The GPCRdb is available at https:\/\/gpcrdb.org.<\/jats:p>","DOI":"10.1093\/nar\/gkac1013","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:09:08Z","timestamp":1668730148000},"page":"D395-D402","source":"Crossref","is-referenced-by-count":190,"title":["GPCRdb in 2023: state-specific structure models using AlphaFold2 and new ligand resources"],"prefix":"10.1093","volume":"51","author":[{"given":"G\u00e1sp\u00e1r","family":"P\u00e1ndy-Szekeres","sequence":"first","affiliation":[{"name":"Department of Drug Design and Pharmacology, University of Copenhagen , Universitetsparken 2, 2100 Copenhagen, Denmark"},{"name":"Medicinal Chemistry Research Group, Research Center for Natural Sciences , Budapest H-1117, Hungary"}]},{"given":"Jimmy","family":"Caroli","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, University of Copenhagen , Universitetsparken 2, 2100 Copenhagen, Denmark"}]},{"given":"Alibek","family":"Mamyrbekov","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, University of Copenhagen , Universitetsparken 2, 2100 Copenhagen, Denmark"}]},{"given":"Ali A","family":"Kermani","sequence":"additional","affiliation":[{"name":"Department of Structural Biology, St. Jude Children's Research Hospital , Memphis, TN 38105, USA"}]},{"given":"Gy\u00f6rgy\u00a0M","family":"Keser\u0171","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Research Group, Research Center for Natural Sciences , Budapest H-1117, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5514-6021","authenticated-orcid":false,"given":"Albert\u00a0J","family":"Kooistra","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, University of Copenhagen , Universitetsparken 2, 2100 Copenhagen, Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4299-7561","authenticated-orcid":false,"given":"David E","family":"Gloriam","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, University of Copenhagen , Universitetsparken 2, 2100 Copenhagen, Denmark"}]}],"member":"286","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"2023010804282056000_B1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1186\/1471-2164-8-338","article-title":"The g protein-coupled receptor subset of the rat genome","volume":"8","author":"Gloriam","year":"2007","journal-title":"BMC Genomics"},{"key":"2023010804282056000_B2","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkaa1100","article-title":"UniProt: the universal protein knowledgebase in 2021","volume":"49","author":"UniProt Consortium","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2023010804282056000_B3","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.cell.2019.10.010","article-title":"Discovery of human signaling systems: pairing peptides to g protein-coupled receptors","volume":"179","author":"Foster","year":"2019","journal-title":"Cell"},{"key":"2023010804282056000_B4","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nrd.2017.178","article-title":"Trends in GPCR drug discovery: new agents, targets and indications","volume":"16","author":"Hauser","year":"2017","journal-title":"Nat. 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