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Here we present a database for the COvid-19 Multi-omics Blood ATlas (COMBAT) project, COMBATdb (https:\/\/db.combat.ox.ac.uk). This enables exploration of multi-modal datasets arising from profiling of patients with different severities of illness admitted to hospital in the first phase of the pandemic in the UK prior to vaccination, compared with community cases, healthy controls, and patients with all-cause sepsis and influenza. These data include whole blood transcriptomics, plasma proteomics, epigenomics, single-cell multi-omics, immune repertoire sequencing, flow and mass cytometry, and cohort metadata. COMBATdb provides access to the processed data in a well-defined framework of samples, cell types and genes\/proteins that allows exploration across the assayed modalities, with functionality including browse, search, download, calculation and visualisation via shiny apps. This advances the ability of users to leverage COMBAT datasets to understand the pathogenesis of COVID-19, and the nature of specific and shared features with other infectious diseases.<\/jats:p>","DOI":"10.1093\/nar\/gkac1019","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T09:52:57Z","timestamp":1668073977000},"page":"D896-D905","source":"Crossref","is-referenced-by-count":15,"title":["COMBATdb: a database for the COVID-19 Multi-Omics Blood ATlas"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9925-4574","authenticated-orcid":false,"given":"Dapeng","family":"Wang","sequence":"first","affiliation":[{"name":"Wellcome Centre for Human Genetics, University of Oxford , Oxford OX3 7BN , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[{"name":"Kennedy Institute for Rheumatology, University of Oxford , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie L","family":"Burnham","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute , Cambridge , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4502-2209","authenticated-orcid":false,"given":"Alexander J","family":"Mentzer","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Human Genetics, University of Oxford , Oxford OX3 7BN , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian\u00a0D","family":"Marsden","sequence":"additional","affiliation":[{"name":"Kennedy Institute for Rheumatology, University of Oxford , UK"},{"name":"Centre for Medicines Discovery, NDM, University of Oxford , Oxford , OX3 7BN , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0377-5536","authenticated-orcid":false,"given":"Julian C","family":"Knight","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Human Genetics, University of Oxford , Oxford OX3 7BN , UK"},{"name":"Chinese Academy of Medical Science Oxford Institute, University of Oxford , UK"},{"name":"NIHR Oxford Biomedical Research Centre , Oxford , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"2023010804224299400_B1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.immuni.2022.02.006","article-title":"Single-cell immunology: past, present, and future","volume":"55","author":"Ginhoux","year":"2022","journal-title":"Immunity"},{"key":"2023010804224299400_B2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.coisb.2019.03.003","article-title":"Systems immunology: integrating multi-omics data to infer regulatory networks and hidden drivers of immunity","volume":"15","author":"Yu","year":"2019","journal-title":"Curr. 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