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The key avenue is to identify the essential molecular phenotypes that mediate the causal variant and disease under particular biological conditions. Therefore, integrating GWAS signals with context-specific quantitative trait loci (QTLs) (such as different tissue\/cell types, disease states, and perturbations) from extensive molecular phenotypes would present important strategies for full understanding of disease genetics. Via persistent curation and systematic data processing of large-scale human molecular trait QTLs (xQTLs), we updated our previous QTLbase database (now QTLbase2, http:\/\/mulinlab.org\/qtlbase) to comprehensively analyze and visualize context-specific QTLs across 22 molecular phenotypes and over 95 tissue\/cell types. Overall, the resource features the following major updates and novel functions: (i) 960 more genome-wide QTL summary statistics from 146 independent studies; (ii) new data for 10 previously uncompiled QTL types; (iii) variant query scope expanded to fit 195 QTL datasets based on whole-genome sequencing; (iv) supports filtering and comparison of QTLs for different biological conditions, such as stimulation types and disease states; (v) a new linkage disequilibrium viewer to facilitate variant prioritization across tissue\/cell types and QTL types.<\/jats:p>","DOI":"10.1093\/nar\/gkac1020","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T09:58:08Z","timestamp":1667555888000},"page":"D1122-D1128","source":"Crossref","is-referenced-by-count":31,"title":["QTLbase2: an enhanced catalog of human quantitative trait loci on extensive molecular 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