{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:28:34Z","timestamp":1777606114211,"version":"3.51.4"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ERC Starting","award":["948770-DECIPHER"],"award-info":[{"award-number":["948770-DECIPHER"]}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF20CC0035580"],"award-info":[{"award-number":["NNF20CC0035580"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF16OC0021746"],"award-info":[{"award-number":["NNF16OC0021746"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"publisher","award":["DNRF137"],"award-info":[{"award-number":["DNRF137"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"publisher","award":["U24AT010811"],"award-info":[{"award-number":["U24AT010811"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"publisher","award":["F32AT011475"],"award-info":[{"award-number":["F32AT011475"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Sciences and Engineering Council of Canada"},{"name":"Netherlands Organization for Scientific Research (NWO) Veni Science","award":["VI.Veni.202.130"],"award-info":[{"award-number":["VI.Veni.202.130"]}]},{"name":"CARTNET","award":["765147"],"award-info":[{"award-number":["765147"]}]},{"name":"SECRETed","award":["101000794"],"award-info":[{"award-number":["101000794"]}]},{"name":"MARBLES","award":["101000392"],"award-info":[{"award-number":["101000392"]}]},{"name":"Horizon 2020 Marie Sk\u0142odowska-Curie Actions","award":["893122"],"award-info":[{"award-number":["893122"]}]},{"name":"Horizon 2020 Marie Sklodowska-Curie Individual Fellowship","award":["MSCA-IF-EF-ST-897121"],"award-info":[{"award-number":["MSCA-IF-EF-ST-897121"]}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","award":["DE-AC02-05CH11231"],"award-info":[{"award-number":["DE-AC02-05CH11231"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008078","name":"University of Strathclyde","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008078","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["757173"],"award-info":[{"award-number":["757173"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Portuguese Science and Technology Foundation","doi-asserted-by":"publisher","award":["SFRH\/BD\/140567\/2018"],"award-info":[{"award-number":["SFRH\/BD\/140567\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CBET-2032243"],"award-info":[{"award-number":["CBET-2032243"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2022R1C1C2004118"],"award-info":[{"award-number":["NRF-2022R1C1C2004118"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2020R1C1C1004046"],"award-info":[{"award-number":["NRF-2020R1C1C1004046"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM134688"],"award-info":[{"award-number":["GM134688"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AI155694"],"award-info":[{"award-number":["1R01AI155694"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013407","name":"Netherlands eScience Center","doi-asserted-by":"publisher","award":["ASDI.2017.030"],"award-info":[{"award-number":["ASDI.2017.030"]}],"id":[{"id":"10.13039\/100013407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["398967434-TRR 261"],"award-info":[{"award-number":["398967434-TRR 261"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BBSRC"],"award-info":[{"award-number":["BBSRC"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/R022054\/1"],"award-info":[{"award-number":["BB\/R022054\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/W013959\/1"],"award-info":[{"award-number":["BB\/W013959\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UK government Department for Environment, Food and Rural Affairs"},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/211.314\/2019"],"award-info":[{"award-number":["E-26\/211.314\/2019"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7ao para a Ciencia e Tecnologia","award":["SFRH\/BD\/136367\/2018"],"award-info":[{"award-number":["SFRH\/BD\/136367\/2018"]}]},{"name":"German Chemical Industry scholarship"},{"name":"Cooperative Research Centres Projects scheme","award":["CRCPFIVE000119"],"award-info":[{"award-number":["CRCPFIVE000119"]}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["735867"],"award-info":[{"award-number":["735867"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Sciences and Engineering Council of Canada PGSD"},{"name":"Odo van Vloten foundation"},{"name":"LOEWE Center for Translational Biodiversity Genomics"},{"name":"Rothamsted Science Initiatives Catalyst Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>With an ever-increasing amount of (meta)genomic data being deposited in sequence databases, (meta)genome mining for natural product biosynthetic pathways occupies a critical role in the discovery of novel pharmaceutical drugs, crop protection agents and biomaterials. The genes that encode these pathways are often organised into biosynthetic gene clusters (BGCs). In 2015, we defined the Minimum Information about a Biosynthetic Gene cluster (MIBiG): a standardised data format that describes the minimally required information to uniquely characterise a BGC. We simultaneously constructed an accompanying online database of BGCs, which has since been widely used by the community as a reference dataset for BGCs and was expanded to 2021 entries in 2019 (MIBiG 2.0). Here, we describe MIBiG 3.0, a database update comprising large-scale validation and re-annotation of existing entries and 661 new entries. Particular attention was paid to the annotation of compound structures and biological activities, as well as protein domain selectivities. Together, these new features keep the database up-to-date, and will provide new opportunities for the scientific community to use its freely available data, e.g. for the training of new machine learning models to predict sequence-structure-function relationships for diverse natural products. MIBiG 3.0 is accessible online at https:\/\/mibig.secondarymetabolites.org\/.<\/jats:p>","DOI":"10.1093\/nar\/gkac1049","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T18:34:05Z","timestamp":1668796445000},"page":"D603-D610","source":"Crossref","is-referenced-by-count":411,"title":["MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4058-6718","authenticated-orcid":false,"given":"Barbara R","family":"Terlouw","sequence":"first","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Droevendaalsesteeg, 6708 PB\u00a0 Wageningen , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3764-6051","authenticated-orcid":false,"given":"Kai","family":"Blin","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , Kgs.\u00a0Lyngby, Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2992-1607","authenticated-orcid":false,"given":"Jorge C","family":"Navarro-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Droevendaalsesteeg, 6708 PB\u00a0 Wageningen , The Netherlands"},{"name":"Westerdijk Fungal Biodiversity Institute , Uppsalalaan 8, 3584 CT\u00a0 Utrecht , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3588-892X","authenticated-orcid":false,"given":"Nicole E","family":"Avalon","sequence":"additional","affiliation":[{"name":"Scripps Institution of Oceanography, University of California San Diego , 9500 Gilman Drive, La Jolla , CA 92093-0212 , USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-0717","authenticated-orcid":false,"given":"Marc G","family":"Chevrette","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Science, University of Florida , Gainesville , FL \u00a032611, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5458-1099","authenticated-orcid":false,"given":"Susan","family":"Egbert","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Manitoba , 66 Chancellors Cir, Winnipeg , MB R3T 2N2 , Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1377-3913","authenticated-orcid":false,"given":"Sanghoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Simon Fraser University, 8888 University Drive , Burnaby, British Columbia V5A 1S6 , Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6406-4394","authenticated-orcid":false,"given":"David","family":"Meijer","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Droevendaalsesteeg, 6708 PB\u00a0 Wageningen , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1450-0941","authenticated-orcid":false,"given":"Michael\u00a0J J","family":"Recchia","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Simon Fraser University, 8888 University Drive , Burnaby, British Columbia V5A 1S6 , Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1964-8221","authenticated-orcid":false,"given":"Zachary\u00a0L","family":"Reitz","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Droevendaalsesteeg, 6708 PB\u00a0 Wageningen , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5424-804X","authenticated-orcid":false,"given":"Jeffrey\u00a0A","family":"van\u00a0Santen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Simon Fraser University, 8888 University Drive , Burnaby, British Columbia V5A 1S6 , Canada"},{"name":"Unnatural Products , 2161 Delaware Ave. Suite A, Santa Cruz , CA 95060 , USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1697-3862","authenticated-orcid":false,"given":"Nelly","family":"Selem-Mojica","sequence":"additional","affiliation":[{"name":"Centro de Ciencias Matem\u00e1ticas UNAM , Morelia , M\u00e9xico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5257-2121","authenticated-orcid":false,"given":"Thomas","family":"T\u00f8rring","sequence":"additional","affiliation":[{"name":"Department of Biological and Chemical Engineering, Aarhus University , Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8218-7216","authenticated-orcid":false,"given":"Liana","family":"Zaroubi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Simon Fraser University, 8888 University Drive , Burnaby, British Columbia V5A 1S6 , Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8420-1325","authenticated-orcid":false,"given":"Mohammad","family":"Alanjary","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Droevendaalsesteeg, 6708 PB\u00a0 Wageningen , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1867-9758","authenticated-orcid":false,"given":"Gajender","family":"Aleti","sequence":"additional","affiliation":[{"name":"Food and Animal Sciences, Department of Agricultural and Environmental Sciences, Tennessee State University , Nashville , TN 37209, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7044-2419","authenticated-orcid":false,"given":"C\u00e9sar","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Purdue University , West Lafayette , IN , USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7665-7904","authenticated-orcid":false,"given":"Suhad\u00a0A A","family":"Al-Salihi","sequence":"additional","affiliation":[{"name":"Department of Applied Sciences, University of Technology , Iraq"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1862-6699","authenticated-orcid":false,"given":"Hannah\u00a0E","family":"Augustijn","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Droevendaalsesteeg, 6708 PB\u00a0 Wageningen , The Netherlands"},{"name":"Institute of Biology, Leiden University , Sylviusweg 72, 2333BE Leiden, The Netherlands"}]},{"given":"J\u00a0Abraham","family":"Avelar-Rivas","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional de Gen\u00f3mica para la Biodiversidad-Unidad de Gen\u00f3mica Avanzada , Cinvestav. Km 9.6 Libramiento Norte Carretera Irapuato-Le\u00f3n, CP 36824\u00a0 Irapuato , Gto., M\u00e9xico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5902-2410","authenticated-orcid":false,"given":"Luis\u00a0A","family":"Avitia-Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Institute of Biology, Leiden University , Sylviusweg 72, 2333BE Leiden, The Netherlands"},{"name":"Laboratorio Nacional de Gen\u00f3mica para la Biodiversidad-Unidad de Gen\u00f3mica Avanzada , Cinvestav. Km 9.6 Libramiento Norte Carretera Irapuato-Le\u00f3n, CP 36824\u00a0 Irapuato , Gto., M\u00e9xico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-9497","authenticated-orcid":false,"given":"Francisco","family":"Barona-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Institute of Biology, Leiden University , Sylviusweg 72, 2333BE Leiden, The Netherlands"},{"name":"Laboratorio Nacional de Gen\u00f3mica para la Biodiversidad-Unidad de Gen\u00f3mica Avanzada , Cinvestav. Km 9.6 Libramiento Norte Carretera Irapuato-Le\u00f3n, CP 36824\u00a0 Irapuato , Gto., M\u00e9xico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7753-5527","authenticated-orcid":false,"given":"Jordan","family":"Bernaldo-Ag\u00fcero","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico , Cuernavaca , Morelos , M\u00e9xico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8107-8752","authenticated-orcid":false,"given":"Vincent A","family":"Bielinski","sequence":"additional","affiliation":[{"name":"Synthetic Biology and Bioenergy Group, J. Craig Venter Institute , La Jolla , CA 92037 ,\u00a0 USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9152-2562","authenticated-orcid":false,"given":"Friederike","family":"Biermann","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Droevendaalsesteeg, 6708 PB\u00a0 Wageningen , The Netherlands"},{"name":"Institute of Molecular Bio Science, Goethe-University Frankfurt , D-60438 Frankfurt am Main, Germany"},{"name":"LOEWE Center for Translational Biodiversity Genomics (TBG) , Senckenberganlage 25, 60325 Frankfurt am Main, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6134-1488","authenticated-orcid":false,"given":"Thomas\u00a0J","family":"Booth","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , Kgs.\u00a0Lyngby, Denmark"},{"name":"School of Molecular Sciences, University of Western Australia , Perth , Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4093-0355","authenticated-orcid":false,"given":"Victor\u00a0J","family":"Carrion\u00a0Bravo","sequence":"additional","affiliation":[{"name":"Institute of Biology, Leiden University , Sylviusweg 72, 2333BE Leiden, The Netherlands"},{"name":"Departamento de Microbiolog\u00eda, Instituto de Hortofruticultura Subtropical y Mediterr\u00e1nea \u2018La Mayora\u2019, Universidad de M\u00e1laga-Consejo Superior de Investigaciones Cient\u00edficas (IHSM-UMA-CSIC), Universidad de M\u00e1laga , M\u00e1laga, Spain"},{"name":"Department of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW) , Wageningen , The Netherlands"}]},{"given":"Raquel","family":"Castelo-Branco","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto , Portugal"},{"name":"Faculty of Sciences, University of Porto , 4150 -179 Porto , Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9534-3521","authenticated-orcid":false,"given":"Fernanda\u00a0O","family":"Chagas","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro , Rio de Janeiro , RJ , 21941-599, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6751-8897","authenticated-orcid":false,"given":"Pablo","family":"Cruz-Morales","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , Kgs.\u00a0Lyngby, Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3447-5293","authenticated-orcid":false,"given":"Chao","family":"Du","sequence":"additional","affiliation":[{"name":"Institute of Biology, Leiden University , Sylviusweg 72, 2333BE Leiden, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3670-4849","authenticated-orcid":false,"given":"Katherine\u00a0R","family":"Duncan","sequence":"additional","affiliation":[{"name":"University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences , 141 Cathedral Street, Glasgow , G4 ORE UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6805-3868","authenticated-orcid":false,"given":"Athina","family":"Gavriilidou","sequence":"additional","affiliation":[{"name":"Translational Genome Mining for Natural Products, Interfaculty Institute of Microbiology and Infection Medicine T\u00fcbingen (IMIT), University of T\u00fcbingen , T\u00fcbingen, Germany"},{"name":"Interfaculty Institute for Biomedical Informatics (IBMI), University of T\u00fcbingen , T\u00fcbingen , Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1447-9548","authenticated-orcid":false,"given":"Damien","family":"Gayrard","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology , John Innes Centre, Norwich Research Park, Norwich , NR4 7UH, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6077-7490","authenticated-orcid":false,"given":"Karina","family":"Guti\u00e9rrez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Embryology, Carnegie Institution for Science , 3520 San Martin Drive, Baltimore , MD \u00a021218, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1361-1508","authenticated-orcid":false,"given":"Kristina","family":"Haslinger","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen , Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8751-3279","authenticated-orcid":false,"given":"Eric\u00a0J N","family":"Helfrich","sequence":"additional","affiliation":[{"name":"Institute of Molecular Bio Science, Goethe-University Frankfurt , D-60438 Frankfurt am Main, Germany"},{"name":"LOEWE Center for Translational Biodiversity Genomics (TBG) , Senckenberganlage 25, 60325 Frankfurt am Main, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9340-5511","authenticated-orcid":false,"given":"Justin\u00a0J J","family":"van\u00a0der\u00a0Hooft","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Droevendaalsesteeg, 6708 PB\u00a0 Wageningen , The Netherlands"},{"name":"Department of Biochemistry, University of Johannesburg , Auckland Park, Johannesburg 2006 , South Africa"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3147-6293","authenticated-orcid":false,"given":"Afif\u00a0P","family":"Jati","sequence":"additional","affiliation":[{"name":"Indonesian Society of Bioinformatics And Biodiversity , Indonesia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8241-4455","authenticated-orcid":false,"given":"Edward","family":"Kalkreuter","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Florida Scripps Biomedical Research , 110 Scripps Way, Jupiter , FL 33458, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5676-1859","authenticated-orcid":false,"given":"Nikolaos","family":"Kalyvas","sequence":"additional","affiliation":[{"name":"Westerdijk Fungal Biodiversity Institute , Uppsalalaan 8, 3584 CT\u00a0 Utrecht , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3290-1017","authenticated-orcid":false,"given":"Kyo\u00a0Bin","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Sookmyung Women's University , Seoul , South Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9815-511X","authenticated-orcid":false,"given":"Satria","family":"Kautsar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Florida Scripps Biomedical Research , 110 Scripps Way, Jupiter , FL 33458, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9094-8908","authenticated-orcid":false,"given":"Wonyong","family":"Kim","sequence":"additional","affiliation":[{"name":"Korean Lichen Research Institute, Sunchon National Universtiy , Suncheon , South Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6869-9530","authenticated-orcid":false,"given":"Aditya\u00a0M","family":"Kunjapur","sequence":"additional","affiliation":[{"name":"Department of Chemical & Biomolecular Engineering, University of Delaware , Newark , DE 19716 , USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4422-2302","authenticated-orcid":false,"given":"Yong-Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The University of Hong Kong , Pokfulam Road, Hong Kong , P.R. China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8123-0921","authenticated-orcid":false,"given":"Geng-Min","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge , MA , USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6258-2080","authenticated-orcid":false,"given":"Catarina","family":"Loureiro","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Wageningen University , Stippeneng 4, 6708WE, Wageningen , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4887-9109","authenticated-orcid":false,"given":"Joris\u00a0J R","family":"Louwen","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Droevendaalsesteeg, 6708 PB\u00a0 Wageningen , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4431-5499","authenticated-orcid":false,"given":"Nico\u00a0L L","family":"Louwen","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Droevendaalsesteeg, 6708 PB\u00a0 Wageningen , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9099-3461","authenticated-orcid":false,"given":"George","family":"Lund","sequence":"additional","affiliation":[{"name":"Sustainable Soils and Crops, Rothamsted Research , Harpenden , Hertfordshire , UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7273-0406","authenticated-orcid":false,"given":"Jonathan","family":"Parra","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Farmac\u00e9uticas (INIFAR), Facultad de Farmacia, Universidad de Costa Rica , San Jos\u00e9 , 11501-2060 , Costa Rica"},{"name":"Centro de Investigaciones en Productos Naturales (CIPRONA), Universidad de Costa Rica , San Jos\u00e9 , 11501-2060 , Costa Rica"},{"name":"Centro Nacional de Innovaciones Biotecnol\u00f3gicas (CENIBiot) , CeNAT-CONARE, 1174-1200, San Jos\u00e9 , Costa Rica"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2085-0873","authenticated-orcid":false,"given":"Benjamin","family":"Philmus","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Oregon State University , USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5754-7221","authenticated-orcid":false,"given":"Bita","family":"Pourmohsenin","sequence":"additional","affiliation":[{"name":"Translational Genome Mining for Natural Products, Interfaculty Institute of Microbiology and Infection Medicine T\u00fcbingen (IMIT), University of T\u00fcbingen , T\u00fcbingen, Germany"},{"name":"Interfaculty Institute for Biomedical Informatics (IBMI), University of T\u00fcbingen , T\u00fcbingen , Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3083-954X","authenticated-orcid":false,"given":"Lotte\u00a0J U","family":"Pronk","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Droevendaalsesteeg, 6708 PB\u00a0 Wageningen , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9647-1197","authenticated-orcid":false,"given":"Adriana","family":"Rego","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto , Portugal"},{"name":"Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto , Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9556-3150","authenticated-orcid":false,"given":"Devasahayam\u00a0Arokia\u00a0Balaya","family":"Rex","sequence":"additional","affiliation":[{"name":"Centre for Integrative Omics Data Science, Yenepoya (Deemed to be University) , Mangalore 575018 , India"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6947-7913","authenticated-orcid":false,"given":"Serina","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Environmental Microbiology, Eawag: Swiss Federal Institute for Aquatic Science and Technology , \u00dcberlandstrasse 133, CH-8600\u00a0 D\u00fcbendorf , Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4105-1563","authenticated-orcid":false,"given":"L\u00a0Rodrigo","family":"Rosas-Becerra","sequence":"additional","affiliation":[{"name":"Institute of Biology, Leiden University , Sylviusweg 72, 2333BE Leiden, The Netherlands"},{"name":"Laboratorio Nacional de Gen\u00f3mica para la Biodiversidad-Unidad de Gen\u00f3mica Avanzada , Cinvestav. Km 9.6 Libramiento Norte Carretera Irapuato-Le\u00f3n, CP 36824\u00a0 Irapuato , Gto., M\u00e9xico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4573-1670","authenticated-orcid":false,"given":"Eve\u00a0T","family":"Roxborough","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Nottingham, University Park , Nottingham \u00a0NG7 2RD, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8144-6052","authenticated-orcid":false,"given":"Michelle\u00a0A","family":"Schorn","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Wageningen University , Stippeneng 4, 6708WE, Wageningen , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9858-9444","authenticated-orcid":false,"given":"Darren\u00a0J","family":"Scobie","sequence":"additional","affiliation":[{"name":"University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences , 141 Cathedral Street, Glasgow , G4 ORE UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8352-5897","authenticated-orcid":false,"given":"Kumar\u00a0Saurabh","family":"Singh","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Droevendaalsesteeg, 6708 PB\u00a0 Wageningen , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4129-2890","authenticated-orcid":false,"given":"Nika","family":"Sokolova","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen , Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7855-5984","authenticated-orcid":false,"given":"Xiaoyu","family":"Tang","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology, Shenzhen Bay Laboratory , Shenzhen 518132 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3491-0198","authenticated-orcid":false,"given":"Daniel","family":"Udwary","sequence":"additional","affiliation":[{"name":"DOE Joint Genome Institute , Lawrence Berkeley National Lab, Berkeley, CA,\u00a0 USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8131-1518","authenticated-orcid":false,"given":"Aruna","family":"Vigneshwari","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Szeged , Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6307-1461","authenticated-orcid":false,"given":"Kristiina","family":"Vind","sequence":"additional","affiliation":[{"name":"Host-Microbe Interactomics Group, Wageningen University , 6708 WD Wageningen, The Netherlands"},{"name":"NAICONS Srl , 20139 Milan , Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7482-5721","authenticated-orcid":false,"given":"Sophie\u00a0P J M","family":"Vromans","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Droevendaalsesteeg, 6708 PB\u00a0 Wageningen , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8905-1263","authenticated-orcid":false,"given":"Valentin","family":"Waschulin","sequence":"additional","affiliation":[{"name":"School of Life Sciences, The University of Warwick , Coventry CV4 7AL, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6949-426X","authenticated-orcid":false,"given":"Sam\u00a0E","family":"Williams","sequence":"additional","affiliation":[{"name":"School of Biochemistry, University of Bristol, University Walk , Bristol BS8 1TD, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6273-5377","authenticated-orcid":false,"given":"Jaclyn\u00a0M","family":"Winter","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, University of Utah , Salt Lake City , UT 84112 , USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6385-3655","authenticated-orcid":false,"given":"Thomas\u00a0E","family":"Witte","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biomolecular Sciences, University of Ottawa , Ottawa , Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6581-9573","authenticated-orcid":false,"given":"Huali","family":"Xie","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Droevendaalsesteeg, 6708 PB\u00a0 Wageningen , The Netherlands"},{"name":"Key laboratory of Detection for Biotoxins, Ministry of Agriculture and Rural Affairs and Oil Crops Research Institute, Chinese Academy of Agricultural Sciences , Wuhan 430061 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2917-0663","authenticated-orcid":false,"given":"Dong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Natural Products Discovery Center, UF Scripps Biomedical Research, University of Florida , Jupiter , FL 33458 , USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4268-436X","authenticated-orcid":false,"given":"Jingwei","family":"Yu","sequence":"additional","affiliation":[{"name":"SUSTech-PKU Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology , Shenzhen , Guangdong 518055 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6534-6609","authenticated-orcid":false,"given":"Mitja","family":"Zdouc","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Droevendaalsesteeg, 6708 PB\u00a0 Wageningen , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1262-4115","authenticated-orcid":false,"given":"Zheng","family":"Zhong","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Wageningen University , Stippeneng 4, 6708WE, Wageningen , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8152-6642","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Collemare","sequence":"additional","affiliation":[{"name":"Westerdijk Fungal Biodiversity Institute , Uppsalalaan 8, 3584 CT\u00a0 Utrecht , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1818-4971","authenticated-orcid":false,"given":"Roger\u00a0G","family":"Linington","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Simon Fraser University, 8888 University Drive , Burnaby, British Columbia V5A 1S6 , Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-5120","authenticated-orcid":false,"given":"Tilmann","family":"Weber","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , Kgs.\u00a0Lyngby, Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2191-2821","authenticated-orcid":false,"given":"Marnix\u00a0H","family":"Medema","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Droevendaalsesteeg, 6708 PB\u00a0 Wageningen , The Netherlands"},{"name":"Institute of Biology, Leiden University , Sylviusweg 72, 2333BE Leiden, The Netherlands"}]}],"member":"286","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"2023010804323334900_B1","doi-asserted-by":"crossref","first-page":"W29","DOI":"10.1093\/nar\/gkab335","article-title":"AntiSMASH 6.0: improving cluster detection and comparison capabilities","volume":"49","author":"Blin","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2023010804323334900_B2","doi-asserted-by":"crossref","first-page":"W55","DOI":"10.1093\/nar\/gkx305","article-title":"PlantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clusters","volume":"45","author":"Kautsar","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2023010804323334900_B3","doi-asserted-by":"crossref","DOI":"10.1101\/2021.05.03.442509","article-title":"Accurate de novo identification of biosynthetic gene clusters with GECCO","author":"Carroll","year":"2021"},{"key":"2023010804323334900_B4","doi-asserted-by":"crossref","first-page":"E110","DOI":"10.1093\/nar\/gkz654","article-title":"A deep learning genome-mining strategy for biosynthetic gene cluster prediction","volume":"47","author":"Hannigan","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2023010804323334900_B5","doi-asserted-by":"crossref","first-page":"W80","DOI":"10.1093\/nar\/gkx408","article-title":"RiPPMiner: a bioinformatics resource for deciphering chemical structures of ripps based on prediction of cleavage and cross-links","volume":"45","author":"Agrawal","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2023010804323334900_B6","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1038\/s41467-020-19986-1","article-title":"Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences","volume":"11","author":"Skinnider","year":"2020","journal-title":"Nat. Commun."},{"key":"2023010804323334900_B7","first-page":"D454","article-title":"MIBiG 2.0: a repository for biosynthetic gene clusters of known function","volume":"48","author":"Kautsar","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2023010804323334900_B8","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nchembio.1890","article-title":"Minimum information about a biosynthetic gene cluster","volume":"11","author":"Medema","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"2023010804323334900_B9","doi-asserted-by":"crossref","first-page":"D1317","DOI":"10.1093\/nar\/gkab941","article-title":"The natural products atlas 2.0: a database of microbially-derived natural products","volume":"50","author":"Van\u00a0Santen","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2023010804323334900_B10","doi-asserted-by":"crossref","first-page":"D1388","DOI":"10.1093\/nar\/gkaa971","article-title":"PubChem in 2021: new data content and improved web interfaces","volume":"49","author":"Kim","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2023010804323334900_B11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41586-022-04862-3","article-title":"Biosynthetic potential of the global ocean microbiome","volume":"607","author":"Paoli","year":"2022","journal-title":"Nature"},{"key":"2023010804323334900_B12","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41587-020-0718-6","article-title":"A genomic catalog of earth's microbiomes","volume":"39","author":"Nayfach","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"2023010804323334900_B13","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1038\/s41467-021-22623-0","article-title":"Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity","volume":"12","author":"Izor\u00e9","year":"2021","journal-title":"Nat. Commun."},{"key":"2023010804323334900_B14","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41564-022-01110-2","article-title":"Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes","volume":"7","author":"Gavriilidou","year":"2022","journal-title":"Nat. Microbiol."},{"key":"2023010804323334900_B15","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1021\/acs.jcim.0c01304","article-title":"A machine learning bioinformatics method to predict biological activity from biosynthetic gene clusters","volume":"61","author":"Walker","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"2023010804323334900_B16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1021\/ci00057a005","article-title":"SMILES, a chemical language and information system","volume":"28","author":"Weininger","year":"1988","journal-title":"J. Chem. Inf. Model."},{"key":"2023010804323334900_B17","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1039\/C5NP90022K","article-title":"Editorial: chemspider-a tool for natural products research","volume":"32","author":"Kelly","year":"2015","journal-title":"Nat. Prod. Rep."},{"key":"2023010804323334900_B18","doi-asserted-by":"crossref","first-page":"e70780","DOI":"10.7554\/eLife.70780","article-title":"The LOTUS initiative for open natural products research","volume":"11","author":"Rutz","year":"2021","journal-title":"Elife"},{"key":"2023010804323334900_B19","doi-asserted-by":"crossref","first-page":"D945","DOI":"10.1093\/nar\/gkw1074","article-title":"The ChEMBL database in 2017","volume":"45","author":"Gaulton","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2023010804323334900_B20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13321-022-00616-5","article-title":"PIKAChU: a Python-based informatics kit for analysing chemical units","volume":"14","author":"Terlouw","year":"2022","journal-title":"J. Cheminform."},{"key":"2023010804323334900_B21","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.jmb.2007.02.099","article-title":"Comprehensive analysis of distinctive polyketide and nonribosomal peptide structural motifs encoded in microbial genomes","volume":"368","author":"Minowa","year":"2007","journal-title":"J. Mol. Biol."},{"key":"2023010804323334900_B22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4939-3375-4_1","article-title":"Structural biology of non-ribosomal peptide synthetases","volume":"1401","author":"Miller","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"2023010804323334900_B23","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1093\/bioinformatics\/btx400","article-title":"SANDPUMA: ensemble predictions of nonribosomal peptide chemistry reveal biosynthetic diversity across actinobacteria","volume":"33","author":"Chevrette","year":"2017","journal-title":"Bioinformatics"},{"key":"2023010804323334900_B24","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/nar\/gkr323","article-title":"NRPSpredictor2 - a web server for predicting NRPS adenylation domain specificity","volume":"39","author":"R\u00f6ttig","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2023010804323334900_B25","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1021\/ci100050t","article-title":"Extended-connectivity fingerprints","volume":"50","author":"Rogers","year":"2010","journal-title":"J. Chem. Inf. Model."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/51\/D1\/D603\/48441454\/gkac1049.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/51\/D1\/D603\/48441454\/gkac1049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T04:36:33Z","timestamp":1673152593000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/51\/D1\/D603\/6833236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,18]]},"references-count":25,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2022,11,18]]},"published-print":{"date-parts":[[2023,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkac1049","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,6]]},"published":{"date-parts":[[2022,11,18]]}}}