{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:00:13Z","timestamp":1784750413523,"version":"3.55.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Shanghai Sailing Program","award":["20YF1402700"],"award-info":[{"award-number":["20YF1402700"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000479"],"award-info":[{"award-number":["32000479"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State Key Laboratory of Chemical Oncogenomics"},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0905900"],"award-info":[{"award-number":["2019YFA0905900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Grant of Ningbo University","award":["215-432000282"],"award-info":[{"award-number":["215-432000282"]}]},{"name":"Ningbo Top Talent Project","award":["215-432094250"],"award-info":[{"award-number":["215-432094250"]}]},{"DOI":"10.13039\/501100021177","name":"Shenzhen Bay Laboratory","doi-asserted-by":"publisher","award":["201901"],"award-info":[{"award-number":["201901"]}],"id":[{"id":"10.13039\/501100021177","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M690714"],"award-info":[{"award-number":["2021M690714"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Quantitative activity and species source data of natural products (NPs) are important for drug discovery, medicinal plant research, and microbial investigations. Activity values of NPs against specific targets are useful for discovering targeted therapeutic agents and investigating the mechanism of medicinal plants. Composition\/concentration values of NPs in individual species facilitate the assessments and investigations of the therapeutic quality of herbs and phenotypes of microbes. Here, we describe an update of the NPASS natural product activity and species source database previously featured in NAR. This update includes: (i) new data of \u223c95 000 records of the composition\/concentration values of \u223c1 490 NPs\/NP clusters in \u223c390 species, (ii) extended data of activity values of \u223c43 200 NPs against \u223c7 700 targets (\u223c40% and \u223c32% increase, respectively), (iii) extended data of \u223c31 600 species sources of \u223c94 400 NPs (\u223c26% and \u223c32% increase, respectively), (iv) new species types of \u223c440 co-cultured microbes and \u223c420 engineered microbes, (v) new data of \u223c66 600 NPs without experimental activity values but with estimated activity profiles from the established chemical similarity tool Chemical Checker, (vi) new data of the computed drug-likeness properties and the absorption, distribution, metabolism, excretion and toxicity (ADMET) properties for all NPs. NPASS update version is freely accessible at http:\/\/bidd.group\/NPASS.<\/jats:p>","DOI":"10.1093\/nar\/gkac1069","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T11:31:52Z","timestamp":1669721512000},"page":"D621-D628","source":"Crossref","is-referenced-by-count":116,"title":["NPASS database update 2023: quantitative natural product activity and species source database for biomedical research"],"prefix":"10.1093","volume":"51","author":[{"given":"Hui","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy , Shanghai \u00a0201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy , Shanghai \u00a0201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaiqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy , Shanghai \u00a0201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy , Shanghai \u00a0201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaicheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy , Shanghai \u00a0201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caili","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy , Shanghai \u00a0201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1654-5550","authenticated-orcid":false,"given":"Xuyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy , Shanghai \u00a0201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy , Shanghai \u00a0201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyue","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy , Shanghai \u00a0201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxiu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy , Shanghai \u00a0201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanbo","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy , Shanghai \u00a0201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tan","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Chemical Oncogenomics & Key Laboratory of Chemical Biology, Tsinghua University Shenzhen Graduate School, Shenzhen Kivita Innovative Drug Discovery Institute , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Wang","sequence":"additional","affiliation":[{"name":"Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Institute of Drug Discovery Technology, Ningbo University , Ningbo \u00a0315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yi","family":"Chu","sequence":"additional","affiliation":[{"name":"Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Institute of Drug Discovery Technology, Ningbo University , Ningbo \u00a0315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongzhi","family":"Zhuoma","sequence":"additional","affiliation":[{"name":"Medical College, Tibet University , Lhasa 850000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Lab of Agricultural Products Processing and Quality Control of Nanchang City, Jiangxi Agricultural University , Nanchang \u00a0330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianwen","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy , Shanghai \u00a0201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy , Shanghai \u00a0201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5473-8022","authenticated-orcid":false,"given":"Yu Zong","family":"Chen","sequence":"additional","affiliation":[{"name":"Shenzhen Bay Laboratory , Shenzhen \u00a0518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"2023010804321483100_B1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: advances and opportunities","volume":"20","author":"International Natural Product Sciences Taskforce","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"2023010804321483100_B2","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nbt.3034","article-title":"Nature's contribution to today's pharmacopeia","volume":"32","author":"Tao","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"2023010804321483100_B3","doi-asserted-by":"crossref","first-page":"17109","DOI":"10.1038\/nplants.2017.109","article-title":"Demystifying traditional herbal medicine with modern approach","volume":"3","author":"Li","year":"2017","journal-title":"Nat. Plants"},{"key":"2023010804321483100_B4","doi-asserted-by":"crossref","first-page":"D1118","DOI":"10.1093\/nar\/gky965","article-title":"CMAUP: a database of collective molecular activities of useful plants","volume":"47","author":"Zeng","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2023010804321483100_B5","doi-asserted-by":"crossref","first-page":"10002","DOI":"10.1021\/acs.chemrev.9b00063","article-title":"Comprehensive structure-activity relationship studies of macrocyclic natural products enabled by their total syntheses","volume":"119","author":"Itoh","year":"2019","journal-title":"Chem. Rev."},{"key":"2023010804321483100_B6","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1111\/bph.15435","article-title":"The natural product trienomycin a is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer","volume":"178","author":"He","year":"2021","journal-title":"Br J. Pharmacol."},{"key":"2023010804321483100_B7","doi-asserted-by":"crossref","first-page":"e49969","DOI":"10.1371\/journal.pone.0049969","article-title":"What does it take to synergistically combine sub-potent natural products into drug-level potent combinations","volume":"7","author":"Qin","year":"2012","journal-title":"PLoS One"},{"key":"2023010804321483100_B8","doi-asserted-by":"crossref","first-page":"104873","DOI":"10.1016\/j.phrs.2020.104873","article-title":"The pros and cons of traditional chinese medicines in the treatment of COVID-19","volume":"157","author":"Wang","year":"2020","journal-title":"Pharmacol. Res."},{"key":"2023010804321483100_B9","doi-asserted-by":"crossref","first-page":"R48","DOI":"10.1111\/j.1750-3841.2008.00716.x","article-title":"Plant metabolites and nutritional quality of vegetables","volume":"73","author":"Hounsome","year":"2008","journal-title":"J. Food Sci."},{"key":"2023010804321483100_B10","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1021\/jf4002439","article-title":"Chemical composition, plant secondary metabolites, and minerals of green and black teas and the effect of different tea-to-water ratios during their extraction on the composition of their spent leaves as potential additives for ruminants","volume":"61","author":"Ramdani","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"2023010804321483100_B11","doi-asserted-by":"crossref","first-page":"113713","DOI":"10.1016\/j.jep.2020.113713","article-title":"Chemical composition and uterine smooth muscle relaxant activity of essential oils from 10 kinds of blood-activating and stasis-resolving chinese medicinal herbs","volume":"269","author":"Ni","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"2023010804321483100_B12","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1038\/s41467-020-17840-y","article-title":"Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity","volume":"11","author":"Chen","year":"2020","journal-title":"Nat. Commun."},{"key":"2023010804321483100_B13","doi-asserted-by":"crossref","first-page":"D1217","DOI":"10.1093\/nar\/gkx1026","article-title":"NPASS: natural product activity and species source database for natural product research, discovery and tool development","volume":"46","author":"Zeng","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2023010804321483100_B14","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.3390\/nu13124206","article-title":"Development of an unified food composition database for the european project \u201cStance4Health\u201d","volume":"13","author":"Hinojosa-Nogueira","year":"2021","journal-title":"Nutrients"},{"key":"2023010804321483100_B15","doi-asserted-by":"crossref","first-page":"S251","DOI":"10.3177\/jnsv.66.S251","article-title":"Flavonoid database based on indonesian foods","volume":"66","author":"Sefrina","year":"2020","journal-title":"J. Nutr. Sci. Vitaminol (Tokyo)"},{"key":"2023010804321483100_B16","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/s41587-020-0502-7","article-title":"Extending the small-molecule similarity principle to all levels of biology with the chemical checker","volume":"38","author":"Duran-Frigola","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"2023010804321483100_B17","doi-asserted-by":"crossref","first-page":"W5","DOI":"10.1093\/nar\/gkab255","article-title":"ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties","volume":"49","author":"Xiong","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2023010804321483100_B18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nchem.1243","article-title":"Quantifying the chemical beauty of drugs","volume":"4","author":"Bickerton","year":"2012","journal-title":"Nat. Chem."},{"key":"2023010804321483100_B19","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nrd2445","article-title":"The influence of drug-like concepts on decision-making in medicinal chemistry","volume":"6","author":"Leeson","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"2023010804321483100_B20","doi-asserted-by":"crossref","first-page":"5601","DOI":"10.1073\/pnas.1614680114","article-title":"Retrospective analysis of natural products provides insights for future discovery trends","volume":"114","author":"Pye","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023010804321483100_B21","doi-asserted-by":"crossref","first-page":"107521","DOI":"10.1016\/j.biotechadv.2020.107521","article-title":"Expanding the chemical diversity through microorganisms co-culture: current status and outlook","volume":"40","author":"Arora","year":"2020","journal-title":"Biotechnol. Adv."},{"key":"2023010804321483100_B22","doi-asserted-by":"crossref","first-page":"6954","DOI":"10.1039\/C4CS00114A","article-title":"Synthetic microbial consortia: from systematic analysis to construction and applications","volume":"43","author":"Song","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"2023010804321483100_B23","doi-asserted-by":"crossref","first-page":"107966","DOI":"10.1016\/j.biotechadv.2022.107966","article-title":"Microbial chassis engineering drives heterologous production of complex secondary metabolites","volume":"59","author":"Liu","year":"2022","journal-title":"Biotechnol. Adv."},{"key":"2023010804321483100_B24","doi-asserted-by":"crossref","first-page":"D600","DOI":"10.1093\/nar\/gkaa868","article-title":"StreptomeDB 3.0: an updated compendium of streptomycetes natural products","volume":"49","author":"Moumbock","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2023010804321483100_B25","doi-asserted-by":"crossref","first-page":"D1317","DOI":"10.1093\/nar\/gkab941","article-title":"The natural products atlas 2.0: a database of microbially-derived natural products","volume":"50","author":"van\u00a0Santen","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2023010804321483100_B26","doi-asserted-by":"crossref","first-page":"D509","DOI":"10.1093\/nar\/gkaa763","article-title":"CMNPD: a comprehensive marine natural products database towards facilitating drug discovery from the ocean","volume":"49","author":"Lyu","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2023010804321483100_B27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13321-020-00478-9","article-title":"COCONUT online: collection of open natural products database","volume":"13","author":"Sorokina","year":"2021","journal-title":"J. Cheminform."},{"key":"2023010804321483100_B28","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s11101-015-9414-4","article-title":"Brassicaceae: a rich source of health improving phytochemicals","volume":"14","author":"Avato","year":"2015","journal-title":"Phytochem. Rev."},{"key":"2023010804321483100_B29","doi-asserted-by":"crossref","first-page":"D10","DOI":"10.1093\/nar\/gkaa892","article-title":"Database resources of the national center for biotechnology information","volume":"49","author":"Sayers","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2023010804321483100_B30","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.3389\/fmicb.2020.02088","article-title":"Understanding the mechanisms of positive microbial interactions that benefit lactic acid bacteria Co-cultures","volume":"11","author":"Canon","year":"2020","journal-title":"Front. Microbiol."},{"key":"2023010804321483100_B31","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/s41589-018-0091-7","article-title":"Designing microbial consortia with defined social interactions","volume":"14","author":"Kong","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"2023010804321483100_B32","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41557-022-00923-2","article-title":"Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria","volume":"14","author":"Shi","year":"2022","journal-title":"Nat. Chem."},{"key":"2023010804321483100_B33","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41573-022-00414-6","article-title":"Strategies to access biosynthetic novelty in bacterial genomes for drug discovery","volume":"21","author":"Hemmerling","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"2023010804321483100_B34","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1038\/s41467-021-24133-5","article-title":"Mining and unearthing hidden biosynthetic potential","volume":"12","author":"Scherlach","year":"2021","journal-title":"Nat. Commun."},{"key":"2023010804321483100_B35","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41576-021-00363-7","article-title":"Mining genomes to illuminate the specialized chemistry of life","volume":"22","author":"Medema","year":"2021","journal-title":"Nat. Rev. Genet."},{"key":"2023010804321483100_B36","doi-asserted-by":"crossref","first-page":"baaa062","DOI":"10.1093\/database\/baaa062","article-title":"NCBI taxonomy: a comprehensive update on curation, resources and tools","volume":"2020","author":"Schoch","year":"2020","journal-title":"Database (Oxford)"},{"key":"2023010804321483100_B37","doi-asserted-by":"crossref","first-page":"W293","DOI":"10.1093\/nar\/gkab301","article-title":"Interactive tree of life (iTOL) v5: an online tool for phylogenetic tree display and annotation","volume":"49","author":"Letunic","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2023010804321483100_B38","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.drudis.2016.11.024","article-title":"Molecular similarity considerations in the licensing of orphan drugs","volume":"22","author":"Franco","year":"2017","journal-title":"Drug Discov. Today"},{"key":"2023010804321483100_B39","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1021\/jm300288g","article-title":"Charting, navigating, and populating natural product chemical space for drug discovery","volume":"55","author":"Lachance","year":"2012","journal-title":"J. Med. Chem."},{"key":"2023010804321483100_B40","doi-asserted-by":"crossref","first-page":"9325","DOI":"10.1038\/srep09325","article-title":"Clustered distribution of natural product leads of drugs in the chemical space as influenced by the privileged target-sites","volume":"5","author":"Tao","year":"2015","journal-title":"Sci. Rep."},{"key":"2023010804321483100_B41","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1471-2105-13-106","article-title":"Natural product-likeness score revisited: an open-source, open-data implementation","volume":"13","author":"Jayaseelan","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"2023010804321483100_B42","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1038\/s41467-021-24150-4","article-title":"Bioactivity descriptors for uncharacterized chemical compounds","volume":"12","author":"Bertoni","year":"2021","journal-title":"Nat. Commun."},{"key":"2023010804321483100_B43","doi-asserted-by":"crossref","first-page":"e202200005","DOI":"10.1002\/cmtd.202200005","article-title":"ChemPlot, a python library for chemical space visualization**","volume":"2","author":"Cihan\u00a0Sorkun","year":"2022","journal-title":"Chemistry\u2013Methods"},{"key":"2023010804321483100_B44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"2023010804321483100_B45","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","article-title":"Lead- and drug-like compounds: the rule-of-five revolution","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discov. Today Technol."},{"key":"2023010804321483100_B46","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1056-8719(00)00107-6","article-title":"Drug-like properties and the causes of poor solubility and poor permeability","volume":"44","author":"Lipinski","year":"2000","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"2023010804321483100_B47","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nrd1032","article-title":"ADMET in silico modelling: towards prediction paradise?","volume":"2","author":"van\u00a0de\u00a0Waterbeemd","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"2023010804321483100_B48","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2165\/00126839-200708060-00003","article-title":"Improving early drug discovery through ADME modelling: an overview","volume":"8","author":"Wishart","year":"2007","journal-title":"Drugs R D"},{"key":"2023010804321483100_B49","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41477-022-01100-6","article-title":"Global plant diversity as a reservoir of micronutrients for humanity","volume":"8","author":"Cantwell-Jones","year":"2022","journal-title":"Nat. Plants"},{"key":"2023010804321483100_B50","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s43016-021-00243-7","article-title":"Network medicine framework shows that proximity of polyphenol targets and disease proteins predicts therapeutic effects of polyphenols","volume":"2","author":"Valle","year":"2021","journal-title":"Nat. Food"},{"key":"2023010804321483100_B51","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1002\/ptr.6427","article-title":"The neuroprotective activities of natural products through the nrf2 upregulation","volume":"33","author":"Tavakkoli","year":"2019","journal-title":"Phytother Res."},{"key":"2023010804321483100_B52","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1039\/C8NP00077H","article-title":"Non-volatile natural products in plant glandular trichomes: chemistry, biological activities and biosynthesis","volume":"36","author":"Liu","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"2023010804321483100_B53","article-title":"Extraction, purification, quantification, and stability of bioactive spilanthol from acmella oleracea","author":"Grymel","year":"2022","journal-title":"Planta Med."},{"key":"2023010804321483100_B54","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1055\/a-1787-1342","article-title":"Chemical constituents of ulmus minor subsp. minor fruits used in the italian phytoalimurgic tradition and their Anti-inflammatory activity evaluation","volume":"88","author":"D\u2019Angiolo","year":"2022","journal-title":"Planta Med."},{"key":"2023010804321483100_B55","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nrendo.2016.210","article-title":"Functional foods and dietary supplements for the management of dyslipidaemia","volume":"13","author":"Hunter","year":"2017","journal-title":"Nat. Rev. Endocrinol."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/51\/D1\/D621\/48441417\/gkac1069.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/51\/D1\/D621\/48441417\/gkac1069.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T16:15:12Z","timestamp":1701274512000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/51\/D1\/D621\/6851105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,29]]},"references-count":55,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2022,11,29]]},"published-print":{"date-parts":[[2023,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkac1069","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,6]]},"published":{"date-parts":[[2022,11,29]]}}}