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In version 5.2, we removed eight outdated resources, added a new resource (miRNATIP), and ran five prediction algorithms for miRBase and mirGeneDB. In total, mirDIP 5.2 includes 46 364 047 predictions for 27 936 genes and 2734 microRNAs, making it the first database to provide interactions using data from mirGeneDB. Moreover, we curated and integrated 32 497 novel microRNAs from 14 publications to accelerate the use of these novel data. In this release, we also extend the content and functionality of mirDIP by associating contexts with microRNAs, genes, and microRNA\u2013gene interactions. We collected and processed microRNA and gene expression data from 20 resources and acquired information on 330 tissue and disease contexts for 2657 microRNAs, 27 576 genes and 123 651 910 gene\u2013microRNA\u2013tissue interactions. Finally, we improved the usability of mirDIP by enabling the user to search the database using precursor IDs, and we integrated miRAnno, a network-based tool for identifying pathways linked to specific microRNAs. We also provide a mirDIP API to facilitate access to its integrated predictions. Updated mirDIP is available at https:\/\/ophid.utoronto.ca\/mirDIP.<\/jats:p>","DOI":"10.1093\/nar\/gkac1070","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T21:57:07Z","timestamp":1669672627000},"page":"D217-D225","source":"Crossref","is-referenced-by-count":60,"title":["MirDIP 5.2: tissue context annotation and novel microRNA curation"],"prefix":"10.1093","volume":"51","author":[{"given":"Anne-Christin","family":"Hauschild","sequence":"first","affiliation":[{"name":"Department of Medical Informatics, University Medical Center G\u00f6ttingen, Georg-August University , G\u00f6ttingen, Lower Saxony\u00a0 37075 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1934-7472","authenticated-orcid":false,"given":"Chiara","family":"Pastrello","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network , Toronto \u00a0M5T 0S8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitta\u00a0Kirana\u00a0Anindya","family":"Ekaputeri","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, University Medical Center G\u00f6ttingen, Georg-August University , G\u00f6ttingen, Lower Saxony\u00a0 37075 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Bethune-Waddell","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network , Toronto \u00a0M5T 0S8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Abovsky","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network , Toronto \u00a0M5T 0S8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuhaib","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network , Toronto \u00a0M5T 0S8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Kotlyar","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network , Toronto \u00a0M5T 0S8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lu","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network , Toronto \u00a0M5T 0S8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Jurisica","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network , Toronto \u00a0M5T 0S8, Canada"},{"name":"Departments of Medical Biophysics and Computer Science, and Faculty of Dentistry, University of Toronto , Toronto , ON, Canada"},{"name":"Institute of Neuroimmunology, Slovak Academy of Sciences , Bratislava , Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"2023010804220495300_B1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrg2936","article-title":"Gene silencing by microRNAs: contributions of translational repression and mRNA decay","volume":"12","author":"Huntzinger","year":"2011","journal-title":"Nat. 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