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The current update contains 285 drugs (131 for human use). New additions include: (i) the integration of veterinary drugs (154 for animal use only), (ii) the addition of 66 documented off-label uses and iii) the identification of adverse drug events from pharmacovigilance data for pediatric and geriatric patients. Additional enhancements include chemical substructure searching using SMILES and \u2018Target Cards\u2019 based on UniProt accession codes. Statistics of interests include the following: (i) 60% of the covered drugs are on-market drugs with expired patent and exclusivity coverage, 17% are off-market, and 23% are on-market drugs with active patents and exclusivity coverage; (ii) 59% of the drugs are oral, 33% are parenteral and 18% topical, at the level of the active ingredients; (iii) only 3% of all drugs are for animal use only; however, 61% of the veterinary drugs are also approved for human use; (iv) dogs, cats and horses are by far the most represented target species for veterinary drugs;\u00a0(v) the physicochemical property profile of animal drugs is very similar to that of human drugs. Use cases include azaperone, the only sedative approved for swine, and ruxolitinib, a Janus kinase inhibitor.<\/jats:p>","DOI":"10.1093\/nar\/gkac1085","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T08:34:37Z","timestamp":1670574877000},"page":"D1276-D1287","source":"Crossref","is-referenced-by-count":79,"title":["DrugCentral 2023 extends human clinical data and integrates veterinary drugs"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4816-7446","authenticated-orcid":false,"given":"Sorin","family":"Avram","sequence":"first","affiliation":[{"name":"Department of Computational Chemistry, \u201cCoriolan Dragulescu\u201d Institute of Chemistry , 24 Mihai Viteazu Blvd , Timi\u015foara, Timi\u015f\u00a0 300223 , Romania"}]},{"given":"Thomas B","family":"Wilson","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of New Mexico Health Sciences Center , 2502 Marble Ave, Albuquerque, NM 87106 , USA"}]},{"given":"Ramona","family":"Curpan","sequence":"additional","affiliation":[{"name":"Department of Computational Chemistry, \u201cCoriolan Dragulescu\u201d Institute of Chemistry , 24 Mihai Viteazu Blvd , Timi\u015foara, Timi\u015f\u00a0 300223 , Romania"}]},{"given":"Liliana","family":"Halip","sequence":"additional","affiliation":[{"name":"Department of Computational Chemistry, \u201cCoriolan Dragulescu\u201d Institute of Chemistry , 24 Mihai Viteazu Blvd , Timi\u015foara, Timi\u015f\u00a0 300223 , Romania"}]},{"given":"Ana","family":"Borota","sequence":"additional","affiliation":[{"name":"Department of Computational Chemistry, \u201cCoriolan Dragulescu\u201d Institute of Chemistry , 24 Mihai Viteazu Blvd , Timi\u015foara, Timi\u015f\u00a0 300223 , Romania"}]},{"given":"Alina","family":"Bora","sequence":"additional","affiliation":[{"name":"Department of Computational Chemistry, \u201cCoriolan Dragulescu\u201d Institute of Chemistry , 24 Mihai Viteazu Blvd , Timi\u015foara, Timi\u015f\u00a0 300223 , Romania"}]},{"given":"Cristian\u00a0G","family":"Bologa","sequence":"additional","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, University of New Mexico Health Sciences Center , 700 Camino de Salud NE, Albuquerque, NM 87106 , USA"}]},{"given":"Jayme","family":"Holmes","sequence":"additional","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, University of New Mexico Health Sciences Center , 700 Camino de Salud NE, Albuquerque, NM 87106 , USA"}]},{"given":"Jeffrey","family":"Knockel","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of New Mexico , 1901 Redondo S Dr, Albuquerque, NM 87106 , USA"}]},{"given":"Jeremy\u00a0J","family":"Yang","sequence":"additional","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, University of New Mexico Health Sciences Center , 700 Camino de Salud NE, Albuquerque, NM 87106 , USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6195-6976","authenticated-orcid":false,"given":"Tudor\u00a0I","family":"Oprea","sequence":"additional","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, University of New Mexico Health Sciences Center , 700 Camino de Salud NE, Albuquerque, NM 87106 , USA"}]}],"member":"286","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"2023010804315396800_B1","doi-asserted-by":"crossref","first-page":"D932","DOI":"10.1093\/nar\/gkw993","article-title":"DrugCentral: online drug compendium","volume":"45","author":"Ursu","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2023010804315396800_B2","doi-asserted-by":"crossref","first-page":"D963","DOI":"10.1093\/nar\/gky963","article-title":"DrugCentral 2018: an update","volume":"47","author":"Ursu","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2023010804315396800_B3","doi-asserted-by":"crossref","first-page":"D1160","DOI":"10.1093\/nar\/gkaa997","article-title":"DrugCentral 2021 supports drug discovery and repositioning","volume":"49","author":"Avram","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2023010804315396800_B4","doi-asserted-by":"crossref","first-page":"D158","DOI":"10.1093\/nar\/gkw1099","article-title":"UniProt: the universal protein knowledgebase","volume":"45","author":"The UniProt Consortium","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2023010804315396800_B5","doi-asserted-by":"crossref","first-page":"D1214","DOI":"10.1093\/nar\/gkv1031","article-title":"ChEBI in 2016: improved services and an expanding collection of metabolites","volume":"44","author":"Hastings","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2023010804315396800_B6","first-page":"S1","article-title":"THE CONCISE GUIDE TO PHARMACOLOGY 2019\/20: introduction and other protein targets","volume":"176","author":"Alexander","year":"2019","journal-title":"Br. 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