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However, there is a lack of resources that can be used to mine and analyse these dynamically changing tRNA modifications. In this study, we established tModBase (https:\/\/www.tmodbase.com\/) for deciphering the landscape of tRNA modification profiles from epitranscriptome data. We analysed 103 datasets generated with second- and third-generation sequencing technologies and illustrated the misincorporation and termination signals of tRNA modification sites in ten species. We thus systematically demonstrate the modification profiles across different tissues\/cell lines and summarize the characteristics of tRNA-associated human diseases. By integrating transcriptome data from 32 cancers, we developed novel tools for analysing the relationships between tRNA modifications and RNA modification enzymes, the expression of 1442 tRNA-derived small RNAs (tsRNAs), and 654 DNA variations. Our database will provide new insights into the features of tRNA modifications and the biological pathways in which they participate.<\/jats:p>","DOI":"10.1093\/nar\/gkac1087","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T11:51:36Z","timestamp":1669031496000},"page":"D315-D327","source":"Crossref","is-referenced-by-count":31,"title":["tModBase: deciphering the landscape of tRNA modifications and their dynamic changes from epitranscriptome data"],"prefix":"10.1093","volume":"51","author":[{"given":"Hao-Tian","family":"Lei","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang-Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Biosciences, University College London , London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Qiang","family":"Mei","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3863-2786","authenticated-orcid":false,"given":"Jian-Hua","family":"Yang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-2863","authenticated-orcid":false,"given":"Liang-Hu","family":"Qu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7152-1095","authenticated-orcid":false,"given":"Ling-Ling","family":"Zheng","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275, P.R. 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