{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:13:35Z","timestamp":1778134415232,"version":"3.51.4"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"D1","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>NLM\u2019s conserved domain database (CDD) is a collection of protein domain and protein family models constructed as multiple sequence alignments. Its main purpose is to provide annotation for protein and translated nucleotide sequences with the location of domain footprints and associated functional sites, and to define protein domain architecture as a basis for assigning gene product names and putative\/predicted function. CDD has been available publicly for over 20 years and has grown substantially during that time. Maintaining an archive of pre-computed annotation continues to be a challenge and has slowed down the cadence of CDD releases. CDD curation staff builds hierarchical classifications of large protein domain families, adds models for novel domain families via surveillance of the protein \u2018dark matter\u2019 that currently lacks annotation, and now spends considerable effort on providing names and attribution for conserved domain architectures. CDD can be accessed at https:\/\/www.ncbi.nlm.nih.gov\/Structure\/cdd\/cdd.shtml.<\/jats:p>","DOI":"10.1093\/nar\/gkac1096","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T07:56:58Z","timestamp":1670486218000},"page":"D384-D388","source":"Crossref","is-referenced-by-count":1095,"title":["The conserved domain database in 2023"],"prefix":"10.1093","volume":"51","author":[{"given":"Jiyao","family":"Wang","sequence":"first","affiliation":[{"name":"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USA"}]},{"given":"Farideh","family":"Chitsaz","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USA"}]},{"given":"Myra 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Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USA"}]},{"given":"Mingzhang","family":"Yang","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USA"}]},{"given":"Dachuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USA"}]},{"given":"Chanjuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , 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