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EBI Search (https:\/\/www.ebi.ac.uk\/ebisearch) provides a full-text search engine across nearly 5 billion entries, while the Job Dispatcher tools framework (https:\/\/www.ebi.ac.uk\/services) enables the scientific community to perform a diverse range of sequence analysis using popular bioinformatics applications. Both allow users to interact through user-friendly web applications, as well as via RESTful and SOAP-based APIs. Here, we describe recent improvements to these services and updates made to accommodate the increasing data requirements during the COVID-19 pandemic.<\/jats:p>","DOI":"10.1093\/nar\/gkac240","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T19:20:18Z","timestamp":1648495218000},"page":"W276-W279","source":"Crossref","is-referenced-by-count":2218,"title":["Search and sequence analysis tools services from EMBL-EBI in 2022"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8728-9449","authenticated-orcid":false,"given":"F\u00e1bio","family":"Madeira","sequence":"first","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus , Hinxton, Cambridge CB10 1SD , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7037-2422","authenticated-orcid":false,"given":"Matt","family":"Pearce","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus , Hinxton, Cambridge CB10 1SD , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian R N","family":"Tivey","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus , Hinxton, Cambridge CB10 1SD , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Basutkar","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus , Hinxton, Cambridge CB10 1SD , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon","family":"Lee","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus , Hinxton, Cambridge CB10 1SD , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ossama","family":"Edbali","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus , Hinxton, Cambridge CB10 1SD , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandana","family":"Madhusoodanan","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus , Hinxton, Cambridge CB10 1SD , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Kolesnikov","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus , Hinxton, Cambridge CB10 1SD , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1256-7306","authenticated-orcid":false,"given":"Rodrigo","family":"Lopez","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus , Hinxton, Cambridge CB10 1SD , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"2022070423570990300_B1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41579-020-00459-7","article-title":"Characteristics of SARS-CoV-2 and COVID-19","volume":"19","author":"Hu","year":"2021","journal-title":"Nat. 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