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However, the interpretation of SVs, especially located in non-coding DNA, remains challenging. One of the reasons stems in the lack of tools exclusively designed for clinical SVs evaluation acknowledging the 3D chromatin architecture. Therefore, we present TADeus2\u00a0a web server dedicated for a quick investigation of chromatin conformation changes, providing a\u00a0visual framework for the interpretation of SVs affecting topologically associating domains (TADs). This tool provides a convenient visual inspection of SVs, both in a continuous genome view as well as from a rearrangement\u2019s breakpoint perspective. Additionally, TADeus2\u00a0allows the user to assess the influence of analyzed SVs within flaking coding\/non-coding regions based on the Hi-C matrix. Importantly, the SVs pathogenicity is quantified and ranked using TADA, ClassifyCNV tools and sampling-based P-value. TADeus2\u00a0is publicly available at https:\/\/tadeus2.mimuw.edu.pl.<\/jats:p>","DOI":"10.1093\/nar\/gkac318","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T19:17:05Z","timestamp":1650568625000},"page":"W744-W752","source":"Crossref","is-referenced-by-count":12,"title":["<tt>TADeus2<\/tt>: a\u00a0web server facilitating the clinical diagnosis by pathogenicity assessment of structural variations disarranging 3D chromatin structure"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9558-6504","authenticated-orcid":false,"given":"Barbara","family":"Poszewiecka","sequence":"first","affiliation":[{"name":"Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw , 2 Banacha street, 02-097 Warsaw, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1383-8019","authenticated-orcid":false,"given":"Victor Murcia","family":"Pienkowski","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, Marseille Medical Genetics , MMG, Marseille, France"},{"name":"Department\u00a0of\u00a0Medical Genetics, Medical University of Warsaw , Adolfa Pawi\u0144skiego 3c, 02-106 Warsaw, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6000-9387","authenticated-orcid":false,"given":"Karol","family":"Nowosad","sequence":"additional","affiliation":[{"name":"Department\u00a0of\u00a0Cell\u00a0Biology, Erasmus Medical Center , Doctor Molewaterplein 40, 3015 GD Rotterdam, Netherlands"},{"name":"Department\u00a0of\u00a0Biomedical Sciences, Laboratory of Molecular Genetics, Medical University of Lublin , Doktora Witolda Chod\u017aki 1, 20-400 Lublin, Poland"},{"name":"The\u00a0Postgraduate\u00a0School of Molecular Medicine, Medical University of Warsaw , \u017bwirki\u00a0i\u00a0Wigury 61, 02-091 Warsaw, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5865-8372","authenticated-orcid":false,"given":"J\u00e9r\u00f4me\u00a0D","family":"Robin","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, Marseille Medical Genetics , MMG, Marseille, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5523-5198","authenticated-orcid":false,"given":"Krzysztof","family":"Gogolewski","sequence":"additional","affiliation":[{"name":"Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw , 2 Banacha street, 02-097 Warsaw, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-3017","authenticated-orcid":false,"given":"Anna","family":"Gambin","sequence":"additional","affiliation":[{"name":"Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw , 2 Banacha street, 02-097 Warsaw, Poland"}]}],"member":"286","published-online":{"date-parts":[[2022,5,7]]},"reference":[{"key":"2022070423583416600_B1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jgg.2011.02.003","article-title":"The impact of next-generation sequencing on genomics","volume":"38","author":"Zhang","year":"2011","journal-title":"J. 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