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When these data are processed into searchable signatures along with signatures extracted from Genotype-Tissue Expression (GTEx) and Gene Expression Omnibus (GEO), connections between drugs, genes, pathways\u00a0and diseases can be illuminated. SigCom LINCS is a webserver that serves over a million gene expression signatures processed, analyzed, and visualized from LINCS, GTEx, and GEO. SigCom LINCS is built with Signature Commons, a cloud-agnostic skeleton Data Commons with a focus on serving searchable signatures. SigCom LINCS provides a rapid signature similarity search for mimickers and reversers given sets of up and down genes, a gene set, a single gene, or any search term. Additionally, users of SigCom LINCS can perform a metadata search to find and analyze subsets of signatures and find information about genes and drugs. SigCom LINCS is findable, accessible, interoperable, and reusable (FAIR) with metadata linked to standard ontologies and vocabularies. In addition, all the data and signatures within SigCom LINCS are available via a well-documented API. In summary, SigCom LINCS, available at https:\/\/maayanlab.cloud\/sigcom-lincs, is a rich webserver resource for accelerating drug and target discovery in systems pharmacology.<\/jats:p>","DOI":"10.1093\/nar\/gkac328","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T03:19:41Z","timestamp":1650511181000},"page":"W697-W709","source":"Crossref","is-referenced-by-count":101,"title":["SigCom LINCS: data and metadata search engine for a million gene expression signatures"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4836-0518","authenticated-orcid":false,"given":"John Erol","family":"Evangelista","sequence":"first","affiliation":[{"name":"Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health,\u00a0Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Box 1603, New York , NY \u00a0 10029 , USA"}]},{"given":"Daniel J B","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health,\u00a0Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Box 1603, New York , NY \u00a0 10029 , USA"}]},{"given":"Zhuorui","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health,\u00a0Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Box 1603, New York , NY \u00a0 10029 , USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1982-7652","authenticated-orcid":false,"given":"Alexander","family":"Lachmann","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health,\u00a0Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Box 1603, New York , NY \u00a0 10029 , USA"}]},{"given":"Minji","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health,\u00a0Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Box 1603, New York , NY \u00a0 10029 , USA"}]},{"given":"Kerwin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health,\u00a0Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Box 1603, New York , NY \u00a0 10029 , USA"}]},{"given":"Kathleen\u00a0M","family":"Jagodnik","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health,\u00a0Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Box 1603, New York , NY \u00a0 10029 , USA"}]},{"given":"Sherry L","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health,\u00a0Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Box 1603, New York , NY \u00a0 10029 , USA"}]},{"given":"Maxim\u00a0V","family":"Kuleshov","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health,\u00a0Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Box 1603, New York , NY \u00a0 10029 , USA"}]},{"given":"Megan\u00a0L","family":"Wojciechowicz","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health,\u00a0Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Box 1603, New York , NY \u00a0 10029 , USA"}]},{"given":"Stephan\u00a0C","family":"Sch\u00fcrer","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, University of Cincinnati College of Medicine , Cincinnati , OH \u00a0 45267 , USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4510-3102","authenticated-orcid":false,"given":"Mario","family":"Medvedovic","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Miller School of Medicine, University of Miami , Miami ,\u00a0FL 33136,\u00a0 USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6904-1017","authenticated-orcid":false,"given":"Avi","family":"Ma\u2019ayan","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health,\u00a0Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , One Gustave L. 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