{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T19:07:26Z","timestamp":1774033646222,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009360","name":"King's College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009362","name":"South London and Maudsley NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011776","name":"MND Scotland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011776","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000406","name":"Motor Neurone Disease Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000406","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spastic Paraplegia Foundation and Rosetrees Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gene Expression Omnibus (GEO) is a database repository hosting a substantial proportion of publicly available high throughput gene expression data. Gene expression analysis is a powerful tool to gain insight into the mechanisms and processes underlying the biological and phenotypic differences between sample groups. Despite the wide availability of gene expression datasets, their access, analysis, and integration are not trivial and require specific expertise and programming proficiency. We developed the GEOexplorer webserver to allow scientists to access, integrate and analyse gene expression datasets without requiring programming proficiency. Via its user-friendly graphic interface, users can easily apply GEOexplorer to perform interactive and reproducible gene expression analysis of microarray and RNA-seq datasets, while producing a wealth of interactive visualisations to facilitate data exploration and interpretation, and generating a range of publication ready figures. The webserver allows users to search and retrieve datasets from GEO as well as to upload user-generated data and combine and harmonise two datasets to perform joint analyses. GEOexplorer, available at https:\/\/geoexplorer.rosalind.kcl.ac.uk, provides a solution for performing interactive and reproducible analyses of microarray and RNA-seq gene expression data, empowering life scientists to perform exploratory data analysis and differential gene expression analysis on-the-fly without informatics proficiency.<\/jats:p>","DOI":"10.1093\/nar\/gkac364","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T19:15:28Z","timestamp":1651605328000},"page":"W367-W374","source":"Crossref","is-referenced-by-count":47,"title":["GEOexplorer: a webserver for gene expression analysis and visualisation"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5217-2678","authenticated-orcid":false,"given":"Guy P","family":"Hunt","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience , King's College London, London , UK"},{"name":"Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience , King's College London, London , SE5 9NU, UK"},{"name":"Perron Institute for Neurological and Translational Science , Nedlands, WA 6009, Australia"},{"name":"Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University , Murdoch, WA 6150, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6308-7540","authenticated-orcid":false,"given":"Luigi","family":"Grassi","sequence":"additional","affiliation":[{"name":"Biopharmaceutical Development, BioPharmaceuticals R&D , AstraZeneca, Cambridge , CB21 6GH, UK"}]},{"given":"Rafael","family":"Henkin","sequence":"additional","affiliation":[{"name":"Centre for Translational Bioinformatics, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London , Charterhouse Square, London , EC1M 6BQ, UK"}]},{"given":"Fabrizio","family":"Smeraldi","sequence":"additional","affiliation":[{"name":"School of Electronic Engineering and Computer Science, Queen Mary University of London , Mile End Road , London E1 4NS, UK"}]},{"given":"Thomas P","family":"Spargo","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience , King's College London, London , SE5 9NU, UK"}]},{"given":"Renata","family":"Kabiljo","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience , King's College London, London , UK"}]},{"given":"Sulev","family":"Koks","sequence":"additional","affiliation":[{"name":"Perron Institute for Neurological and Translational Science , Nedlands, WA 6009, Australia"},{"name":"Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University , Murdoch, WA 6150, Australia"}]},{"given":"Zina","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience , King's College London, London , UK"}]},{"given":"Richard J B","family":"Dobson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience , King's College London, London , UK"},{"name":"Institute of Health Informatics, University College London , London , UK"},{"name":"National Institute for Health Research Biomedical Research Centre and Dementia Unit at South London and Maudsley NHS Foundation Trust and King's College London , London , UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4924-7712","authenticated-orcid":false,"given":"Ammar","family":"Al-Chalabi","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience , King's College London, London , SE5 9NU, UK"},{"name":"King\u2032s College Hospital , Bessemer Road , Denmark Hill, London , SE5 9RS, UK"}]},{"given":"Michael R","family":"Barnes","sequence":"additional","affiliation":[{"name":"Centre for Translational Bioinformatics, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London , Charterhouse Square, London , EC1M 6BQ, UK"},{"name":"The Alan Turing Institute , London NW1 2DB, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5280-5017","authenticated-orcid":false,"given":"Alfredo","family":"Iacoangeli","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience , King's College London, London , UK"},{"name":"Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, 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