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However, due to the limitations of the currently used applications, there are still considerable challenges in the preparation of biological schematic diagrams. Here, we present a professional tool called IBS 2.0 for illustrating the organization of both protein and nucleotide sequences. With the abundant graphical elements provided in IBS 2.0, biological sequences can be easily represented in a concise and clear way. Moreover, we implemented a database visualization module in IBS 2.0, enabling batch visualization of biological sequences from the UniProt and the NCBI RefSeq databases. Furthermore, to increase the design efficiency, a resource platform that allows uploading, retrieval, and browsing of existing biological sequence diagrams has been integrated into IBS 2.0. In addition, a lightweight JS library was developed in IBS 2.0 to assist the visualization of biological sequences in customized web services. To obtain the latest version of IBS 2.0, please visit https:\/\/ibs.renlab.org.<\/jats:p>","DOI":"10.1093\/nar\/gkac373","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T11:22:50Z","timestamp":1651231370000},"page":"W420-W426","source":"Crossref","is-referenced-by-count":219,"title":["IBS 2.0: an upgraded illustrator for the visualization of biological sequences"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3566-4849","authenticated-orcid":false,"given":"Yubin","family":"Xie","sequence":"first","affiliation":[{"name":"School of Life Sciences, Precision Medicine Institute, the First Affiliated Hospital, Sun Yat-sen University , Guangzhou \u00a0510060,\u00a0 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Precision Medicine Institute, the First Affiliated Hospital, Sun Yat-sen University , Guangzhou \u00a0510060,\u00a0 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Cancer Center, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University , Guangzhou \u00a0510060,\u00a0 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Precision Medicine Institute, the First Affiliated Hospital, Sun Yat-sen University , Guangzhou \u00a0510060,\u00a0 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyuan","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Precision Medicine Institute, the First Affiliated Hospital, Sun Yat-sen University , Guangzhou \u00a0510060,\u00a0 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