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Since the distinct set of cancer driver genes can vary between and within cancer types, evidence-based selection of drugs is crucial for targeted therapy following the precision medicine paradigm. However, many putative cancer driver genes can not be targeted directly, suggesting an indirect approach that considers alternative functionally related targets in the gene interaction network. Once potential drug targets have been identified, it is essential to consider all available drugs. Since tools that offer support for systematic discovery of drug repurposing candidates in oncology are lacking, we developed CADDIE, a web application integrating six human gene-gene and four drug-gene interaction databases, information regarding cancer driver genes, cancer-type specific mutation frequencies, gene expression information, genetically related diseases, and anticancer drugs. CADDIE offers access to various network algorithms for identifying drug targets and drug repurposing candidates. It guides users from the selection of seed genes to the identification of therapeutic targets or drug candidates, making network medicine algorithms accessible for clinical research. CADDIE is available at https:\/\/exbio.wzw.tum.de\/caddie\/ and programmatically via a python package at https:\/\/pypi.org\/project\/caddiepy\/.<\/jats:p>","DOI":"10.1093\/nar\/gkac384","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T19:21:30Z","timestamp":1651260090000},"page":"W138-W144","source":"Crossref","is-referenced-by-count":24,"title":["Cancer driver drug interaction explorer"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3992-0125","authenticated-orcid":false,"given":"Michael","family":"Hartung","sequence":"first","affiliation":[{"name":"Institute for Computational Systems Biology, University of Hamburg , 22607 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Anastasi","sequence":"additional","affiliation":[{"name":"School of Computing, Newcastle University , 2308 Newcastle upon Tyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4201-7973","authenticated-orcid":false,"given":"Zeinab M","family":"Mamdouh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Personalised Medicine, Maastricht University , 6229 Maastricht, Netherlands"},{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University , 44519 Zagazig, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7535-0417","authenticated-orcid":false,"given":"Cristian","family":"Nogales","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Personalised Medicine, Maastricht University , 6229 Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald H H W","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Personalised Medicine, Maastricht University , 6229 Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Baumbach","sequence":"additional","affiliation":[{"name":"Institute for Computational Systems Biology, University of Hamburg , 22607 Hamburg, Germany"},{"name":"Computational Biomedicine Lab, Department of Mathematics and Computer Science, University of Southern Denmark , 5230 Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9424-8052","authenticated-orcid":false,"given":"Olga","family":"Zolotareva","sequence":"additional","affiliation":[{"name":"Institute for Computational Systems Biology, University of Hamburg , 22607 Hamburg, Germany"},{"name":"Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich , 85354\u00a0Freising, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0941-4168","authenticated-orcid":false,"given":"Markus","family":"List","sequence":"additional","affiliation":[{"name":"Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich , 85354\u00a0Freising, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"2022070500011721300_B1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nature12624","article-title":"Tumour heterogeneity and cancer cell plasticity","volume":"501","author":"Meacham","year":"2013","journal-title":"Nature"},{"key":"2022070500011721300_B2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tips.2021.11.004","article-title":"Network pharmacology: curing causal mechanisms instead of treating symptoms","volume":"43","author":"Nogales","year":"2022","journal-title":"Trends Pharmacol. 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