{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:31:55Z","timestamp":1762900315444,"version":"3.37.3"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61732009"],"award-info":[{"award-number":["61732009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Provincial Science and Technology Program","award":["2019CB1007","2021RC4008"],"award-info":[{"award-number":["2019CB1007","2021RC4008"]}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["2021zzts0203"],"award-info":[{"award-number":["2021zzts0203"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Long distance enhancers can physically interact with promoters to regulate gene expression through formation of enhancer-promoter (E-P) interactions. Identification of E-P interactions is also important for profound understanding of normal developmental and disease-associated risk variants. Although the state-of-art predictive computation methods facilitate the identification of E-P interactions to a certain extent, currently there is no efficient method that can meet various requirements of usage. Here we developed EPIXplorer, a user-friendly web server for efficient prediction, analysis and visualization of E-P interactions. EPIXplorer integrates 9 robust predictive algorithms, supports multiple types of 3D contact data and multi-omics data as input. The output from EPIXplorer is scored, fully annotated by regulatory elements and risk single-nucleotide polymorphisms (SNPs). In addition, the Visualization and Downstream module provide further functional analysis, all the output files and high-quality images are available for download. Together, EPIXplorer provides a user-friendly interface to predict the E-P interactions in an acceptable time, as well as understand how the genome-wide association study (GWAS) variants influence disease pathology by altering DNA looping between enhancers and the target gene promoters. EPIXplorer is available at https:\/\/www.csuligroup.com\/EPIXplorer.<\/jats:p>","DOI":"10.1093\/nar\/gkac397","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T11:17:16Z","timestamp":1651749436000},"page":"W290-W297","source":"Crossref","is-referenced-by-count":8,"title":["EPIXplorer: A web server for prediction, analysis and visualization of enhancer-promoter interactions"],"prefix":"10.1093","volume":"50","author":[{"given":"Li","family":"Tang","sequence":"first","affiliation":[{"name":"Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University , Changsha 410083, China"}]},{"given":"Zhizhou","family":"Zhong","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University , Changsha 410083, China"}]},{"given":"Yisheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University , Changsha 410083, China"}]},{"given":"Yifei","family":"Yang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University , Changsha 410083, China"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston , Houston, TX 77030, USA"}]},{"given":"James\u00a0F","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Baylor College of Medicine , Houston, TX 77030, USA"},{"name":"Cardiovascular Research Institute, Baylor College of Medicine , Houston, TX 77030, USA"},{"name":"Texas Heart Institute , Houston, TX 77030, 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