{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:34:11Z","timestamp":1777422851349,"version":"3.51.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1301603"],"award-info":[{"award-number":["2021YFA1301603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1301604"],"award-info":[{"award-number":["2021YFA1301604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFE0202200"],"award-info":[{"award-number":["2020YFE0202200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State Key Laboratory of Proteomics","award":["SKLP-Y202002"],"award-info":[{"award-number":["SKLP-Y202002"]}]},{"name":"State Key Laboratory of Proteomics","award":["SKLP-K201404"],"award-info":[{"award-number":["SKLP-K201404"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32088101"],"award-info":[{"award-number":["32088101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing","doi-asserted-by":"publisher","award":["7202145"],"award-info":[{"award-number":["7202145"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2019-I2M-5-063"],"award-info":[{"award-number":["2019-I2M-5-063"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In the era of life-omics, huge amounts of multi-omics data have been generated and widely used in biomedical research. It is challenging for biologists with limited programming skills to obtain biological insights from multi-omics data. Thus, a biologist-oriented platform containing visualization functions is needed to make complex omics data digestible. Here, we propose an easy-to-use, interactive web server named ExpressVis. In ExpressVis, users can prepare datasets; perform differential expression analysis, clustering analysis, and survival analysis; and integrate expression data with protein\u2013protein interaction networks and pathway maps. These analyses are organized into six modules. Users can use each module independently or use several modules interactively. ExpressVis displays analysis results in interactive figures and tables, and provides comprehensive interactive operations in each figure and table, between figures or tables in each module, and among different modules. It is freely accessible at https:\/\/omicsmining.ncpsb.org.cn\/ExpressVis and does not require login. To test the performance of ExpressVis for multi-omics studies of clinical cohorts, we re-analyzed a published hepatocellular carcinoma dataset and reproduced their main findings, suggesting that ExpressVis is convenient enough to analyze multi-omics data. Based on its complete analysis processes and unique interactive operations, ExpressVis provides an easy-to-use solution for exploring multi-omics data.<\/jats:p>","DOI":"10.1093\/nar\/gkac399","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T19:27:46Z","timestamp":1651865266000},"page":"W312-W321","source":"Crossref","is-referenced-by-count":19,"title":["ExpressVis: a biologist-oriented interactive web server for exploring multi-omics data"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4448-1841","authenticated-orcid":false,"given":"Xian","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing 102206, China"},{"name":"Institute of Health Service and Transfusion Medicine , Beijing 100850, 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(Beijing), Beijing Institute of Lifeomics , Beijing 102206, China"},{"name":"Beijing Institute of Radiation Medicine , Beijing 100850, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangming","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing 102206, China"},{"name":"Beijing Institute of Radiation Medicine , Beijing 100850, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing 102206, China"},{"name":"Beijing Institute of Radiation Medicine , Beijing 100850, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changyan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing 102206, China"},{"name":"Beijing Institute of Radiation Medicine , Beijing 100850, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing 102206, China"},{"name":"Beijing Institute of Radiation Medicine , Beijing 100850, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing 102206, China"},{"name":"Beijing Institute of Radiation Medicine , Beijing 100850, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shensi","family":"Xiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing 102206, China"},{"name":"Beijing Institute of Radiation Medicine , Beijing 100850, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiying","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing 102206, China"},{"name":"Beijing Institute of Radiation Medicine , Beijing 100850, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1911-7922","authenticated-orcid":false,"given":"Xiaochen","family":"Bo","sequence":"additional","affiliation":[{"name":"Institute of Health Service and Transfusion Medicine , Beijing 100850, China"},{"name":"Beijing Institute of Radiation Medicine , Beijing 100850, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0361-2438","authenticated-orcid":false,"given":"Cheng","family":"Chang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing 102206, China"},{"name":"Research Unit of Proteomics Driven Cancer Precision Medicine, Chinese Academy of Medical Sciences , Beijing 102206, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing 102206, China"},{"name":"Beijing Institute of Radiation Medicine , Beijing 100850, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"2022070500010476600_B1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrg2484","article-title":"RNA-Seq: a revolutionary tool for transcriptomics","volume":"10","author":"Wang","year":"2009","journal-title":"Nat. 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