{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:45:39Z","timestamp":1787316339427,"version":"build-2736575974"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","award":["H2001a0P14"],"award-info":[{"award-number":["H2001a0P14"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Industry Alignment Fund","award":["APG2013\/096"],"award-info":[{"award-number":["APG2013\/096"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Proteins in food and personal care products can pose a risk for an immediate immunoglobulin E (IgE)-mediated allergic response. Bioinformatic tools can assist to predict and investigate the allergenic potential of proteins. Here we present AllerCatPro 2.0, a web server that can be used to predict protein allergenicity potential with better accuracy than other computational methods and new features that help assessors making informed decisions. AllerCatPro 2.0 predicts the similarity between input proteins using both their amino acid sequences and predicted 3D structures towards the most comprehensive datasets of reliable proteins associated with allergenicity. These datasets currently include 4979 protein allergens, 162 low allergenic proteins, and 165 autoimmune allergens with manual expert curation from the databases of WHO\/International Union of Immunological Societies (IUIS), Comprehensive Protein Allergen Resource (COMPARE), Food Allergy Research and Resource Program (FARRP), UniProtKB and Allergome. Various examples of profilins, autoimmune allergens, low allergenic proteins, very large proteins, and nucleotide input sequences showcase the utility of AllerCatPro 2.0 for predicting protein allergenicity potential. The AllerCatPro 2.0 web server is freely accessible at https:\/\/allercatpro.bii.a-star.edu.sg.<\/jats:p>","DOI":"10.1093\/nar\/gkac446","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T09:43:23Z","timestamp":1652262203000},"page":"W36-W43","source":"Crossref","is-referenced-by-count":193,"title":["AllerCatPro 2.0: a web server for predicting protein allergenicity potential"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4949-2571","authenticated-orcid":false,"given":"Minh N","family":"Nguyen","sequence":"first","affiliation":[{"name":"Bioinformatics Institute , 30 Biopolis Street , #07-01, Matrix 138671, Singapore"},{"name":"IFCS Programme, Singapore Institute for Food and Biotechnology Innovation, Agency for Science, Technology and Research , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora L","family":"Krutz","sequence":"additional","affiliation":[{"name":"NV Procter & Gamble Services Company SA , Strombeek-Bever, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vachiranee","family":"Limviphuvadh","sequence":"additional","affiliation":[{"name":"Bioinformatics Institute , 30 Biopolis Street , #07-01, Matrix 138671, Singapore"},{"name":"IFCS Programme, Singapore Institute for Food and Biotechnology Innovation, Agency for Science, Technology and Research , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas L","family":"Lopata","sequence":"additional","affiliation":[{"name":"Bioinformatics Institute , 30 Biopolis Street , #07-01, Matrix 138671, Singapore"},{"name":"Molecular Allergy Research Laboratory, Australian Institute of Tropical Health and Medicine, James Cook University , Townsville , QLD, Australia"},{"name":"Tropical Futures Institute, James Cook University , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00a0Frank","family":"Gerberick","sequence":"additional","affiliation":[{"name":"GF3 Consultancy LLC , West Chester , OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0813-9640","authenticated-orcid":false,"given":"Sebastian","family":"Maurer-Stroh","sequence":"additional","affiliation":[{"name":"Bioinformatics Institute , 30 Biopolis Street , #07-01, Matrix 138671, Singapore"},{"name":"IFCS Programme, Singapore Institute for Food and Biotechnology Innovation, Agency for Science, Technology and Research , Singapore"},{"name":"Department of Biological Sciences, National University of Singapore , 14 Science Drive 4 , 117543 , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"2022070423591106000_B1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/10408444.2020.1793895","article-title":"Determination of the relative allergenic potency of proteins: hurdles and opportunities","volume":"50","author":"Krutz","year":"2020","journal-title":"Crit. Rev. Toxicol."},{"key":"2022070423591106000_B2","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1093\/bioinformatics\/btz029","article-title":"AllerCatPro-prediction of protein allergenicity potential from the protein sequence","volume":"35","author":"Maurer-Stroh","year":"2019","journal-title":"Bioinformatics"},{"key":"2022070423591106000_B3","volume-title":"Evaluation of allergenicity of genetically modified foods: report of a Joint FAO\/WHO Expert Consultation on Allergenicity of Foods Derived from Biotechnology","author":"Organization","year":"2001"},{"key":"2022070423591106000_B4","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1186\/1752-0509-7-S5-S9","article-title":"PREAL: prediction of allergenic protein by maximum relevance minimum redundancy (mRMR) feature selection","volume":"7","author":"Wang","year":"2013","journal-title":"BMC Syst. 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Sci."},{"key":"2022070423591106000_B11","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2022070423591106000_B12","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1093\/nar\/gkr348","article-title":"Biological insights from topology independent comparison of protein 3D structures","volume":"39","author":"Nguyen","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2022070423591106000_B13","doi-asserted-by":"crossref","first-page":"W24","DOI":"10.1093\/nar\/gkr393","article-title":"CLICK\u2013topology-independent comparison of biomolecular 3D structures","volume":"39","author":"Nguyen","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2022070423591106000_B14","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1093\/nar\/gkw819","article-title":"Topology independent comparison of RNA 3D structures using the CLICK algorithm","volume":"45","author":"Nguyen","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2022070423591106000_B15","doi-asserted-by":"crossref","first-page":"W482","DOI":"10.1093\/nar\/gkz358","article-title":"AppA: a web server for analysis, comparison, and visualization of contact residues and interfacial waters of antibody-antigen structures and models","volume":"47","author":"Nguyen","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2022070423591106000_B16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000098226","article-title":"Rice: another potential cause of food allergy in patients sensitized to lipid transfer protein","volume":"143","author":"Asero","year":"2007","journal-title":"Int. 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Rheumatol."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/50\/W1\/W36\/44378679\/gkac446.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/50\/W1\/W36\/44378679\/gkac446.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T20:02:43Z","timestamp":1656964963000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/50\/W1\/W36\/6595260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,30]]},"references-count":20,"journal-issue":{"issue":"W1","published-online":{"date-parts":[[2022,5,30]]},"published-print":{"date-parts":[[2022,7,5]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkac446","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,5]]},"published":{"date-parts":[[2022,5,30]]}}}