{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:08:22Z","timestamp":1768583302878,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100533"],"award-info":[{"award-number":["32100533"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021177","name":"Shenzhen Bay Laboratory","doi-asserted-by":"publisher","award":["SZBL2021080601001"],"award-info":[{"award-number":["SZBL2021080601001"]}],"id":[{"id":"10.13039\/501100021177","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Functional interpretation of disease-associated non-coding variants remains a significant challenge in the post-GWAS era. Our recent study has identified 3\u2032UTR alternative polyadenylation (APA) quantitative trait loci (3\u2032aQTLs) and connects APA events with QTLs as a major driver of human traits and diseases. Besides 3\u2032UTR, APA events can also occur in intron regions, and increasing evidence has connected intronic polyadenylation with disease risk. However, systematic investigation of the roles of intronic polyadenylation in human diseases remained challenging due to the lack of a comprehensive database across a variety of human tissues. Here, we developed ipaQTL-atlas (http:\/\/bioinfo.szbl.ac.cn\/ipaQTL) as the first comprehensive portal for intronic polyadenylation. The ipaQTL-atlas is based on the analysis of 15 170 RNA-seq data from 838 individuals across 49 Genotype-Tissue Expression (GTEx v8) tissues and contains \u223c0.98 million SNPs associated with intronic APA events. It provides an interface for ipaQTLs search, genome browser, boxplots, and data download, as well as the visualization of GWAS and ipaQTL colocalization results. ipaQTL-atlas provides a one-stop portal to access intronic polyadenylation information and could significantly advance the discovery of APA-associated disease susceptibility genes.<\/jats:p>","DOI":"10.1093\/nar\/gkac736","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T09:28:42Z","timestamp":1661938122000},"page":"D1046-D1052","source":"Crossref","is-referenced-by-count":13,"title":["ipaQTL-atlas: an atlas of intronic polyadenylation quantitative trait loci across human tissues"],"prefix":"10.1093","volume":"51","author":[{"given":"Xuelian","family":"Ma","sequence":"first","affiliation":[{"name":"Institute of Systems and Physical Biology, Shenzhen Bay Laboratory , Shenzhen 518055 , China"}]},{"given":"Shumin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Systems and Physical Biology, Shenzhen Bay Laboratory , Shenzhen 518055 , China"}]},{"given":"Ruofan","family":"Ding","sequence":"additional","affiliation":[{"name":"Institute of Systems and Physical Biology, Shenzhen Bay Laboratory , Shenzhen 518055 , China"}]},{"given":"Zhaozhao","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, School of Life Sciences and Huashan Hospital, Fudan University , Shanghai 200438 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2958-0438","authenticated-orcid":false,"given":"XuDong","family":"Zou","sequence":"additional","affiliation":[{"name":"Institute of Systems and Physical Biology, Shenzhen Bay Laboratory , Shenzhen 518055 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7700-9634","authenticated-orcid":false,"given":"Shouhong","family":"Guang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Membraneless Organelles and Cellular Dynamics, School of Life Sciences, Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Biomedical Sciences and Health Laboratory of Anhui Province, University of Science and Technology of China , Hefei, Anhui 230027, P.R. China"}]},{"given":"Qixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Systems and Physical Biology, Shenzhen Bay Laboratory , Shenzhen 518055 , China"}]},{"given":"Huan","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Peking University Shenzhen Hospital , Shenzhen 518036, China"}]},{"given":"Chen","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Cancer Research, Shenzhen Bay Laboratory , Shenzhen 518055, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7007-1072","authenticated-orcid":false,"given":"Ting","family":"Ni","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, School of Life Sciences and Huashan Hospital, Fudan University , Shanghai 200438 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3924-2544","authenticated-orcid":false,"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Systems and Physical Biology, Shenzhen Bay Laboratory , Shenzhen 518055 , China"}]}],"member":"286","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"2023010804160945700_B1","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx consortium atlas of genetic regulatory effects across human tissues","volume":"369","author":"Aguet","year":"2020","journal-title":"Science (New York, N.Y.)"},{"key":"2023010804160945700_B2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41398-022-01913-1","article-title":"Allele-specific analysis reveals exon- and cell-type-specific regulatory effects of alzheimer's disease-associated genetic variants","volume":"12","author":"He","year":"2022","journal-title":"Transl. 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