{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T21:58:21Z","timestamp":1775685501210,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MENRT"},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-17-CE12-0017-01"],"award-info":[{"award-number":["ANR-17-CE12-0017-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MENRT"},{"DOI":"10.13039\/501100002915","name":"FRM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004004","name":"University of Trento","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004004","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>RNA G-quadruplexes (RG4s) are non-canonical, disease-associated post-transcriptional regulators of gene expression whose functions are driven by RNA-binding proteins (RBPs). Being able to explore transcriptome-wide RG4 formation and interaction with RBPs is thus paramount to understanding how they are regulated and exploiting them as potential therapeutic targets. Towards this goal, we present QUADRatlas (https:\/\/rg4db.cibio.unitn.it), a database of experimentally-derived and computationally predicted RG4s in the human transcriptome, enriched with biological function and disease associations. As RBPs are key to their function, we mined known interactions of RG4s with such proteins, complemented with an extensive RBP binding sites dataset. Users can thus intersect RG4s with their potential regulators and effectors, enabling the formulation of novel hypotheses on RG4 regulation, function\u00a0and pathogenicity. To support this capability, we provide analysis tools for predicting whether an RBP can bind RG4s, RG4 enrichment in a gene set, and de novo RG4 prediction. Genome-browser and table views allow exploring, filtering, and downloading the data quickly for individual genes and in batch. QUADRatlas is a significant step forward in our ability to understand the biology of RG4s, offering unmatched data content and enabling the integrated analysis of RG4s and their interactions with RBPs.<\/jats:p>","DOI":"10.1093\/nar\/gkac782","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T08:35:06Z","timestamp":1663662906000},"page":"D240-D247","source":"Crossref","is-referenced-by-count":43,"title":["QUADRatlas: the RNA G-quadruplex and RG4-binding proteins database"],"prefix":"10.1093","volume":"51","author":[{"given":"S\u00e9bastien","family":"Bourdon","sequence":"first","affiliation":[{"name":"Laboratory of RNA Regulatory Networks, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento ,\u00a038123\u00a0 Trento , Italy"},{"name":"Cancer Research Centre of Toulouse, INSERM UMR 1037 ,\u00a031037\u00a0 Toulouse , France"},{"name":"Universit\u00e9 Toulouse III \u2013 Paul Sabatier ,\u00a031330\u00a0 Toulouse , France"}]},{"given":"Pauline","family":"Herviou","sequence":"additional","affiliation":[{"name":"Cancer Research Centre of Toulouse, INSERM UMR 1037 ,\u00a031037\u00a0 Toulouse , France"},{"name":"Universit\u00e9 Toulouse III \u2013 Paul Sabatier ,\u00a031330\u00a0 Toulouse , France"}]},{"given":"Le\u00efla","family":"Dumas","sequence":"additional","affiliation":[{"name":"Cancer Research Centre of Toulouse, INSERM UMR 1037 ,\u00a031037\u00a0 Toulouse , France"},{"name":"Universit\u00e9 Toulouse III \u2013 Paul Sabatier ,\u00a031330\u00a0 Toulouse , France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3804-6712","authenticated-orcid":false,"given":"Eliana","family":"Destefanis","sequence":"additional","affiliation":[{"name":"Laboratory of RNA Regulatory Networks, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento ,\u00a038123\u00a0 Trento , Italy"},{"name":"Laboratory of Translational Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento ,\u00a0 38123 \u00a0Trento, Italy"}]},{"given":"Andrea","family":"Zen","sequence":"additional","affiliation":[{"name":"Laboratory of RNA Regulatory Networks, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento ,\u00a038123\u00a0 Trento , Italy"}]},{"given":"Anne","family":"Cammas","sequence":"additional","affiliation":[{"name":"Cancer Research Centre of Toulouse, INSERM UMR 1037 ,\u00a031037\u00a0 Toulouse , France"},{"name":"Universit\u00e9 Toulouse III \u2013 Paul Sabatier ,\u00a031330\u00a0 Toulouse , France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1659-3552","authenticated-orcid":false,"given":"Stefania","family":"Millevoi","sequence":"additional","affiliation":[{"name":"Cancer Research Centre of Toulouse, INSERM UMR 1037 ,\u00a031037\u00a0 Toulouse , France"},{"name":"Universit\u00e9 Toulouse III \u2013 Paul Sabatier ,\u00a031330\u00a0 Toulouse , France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-0449","authenticated-orcid":false,"given":"Erik","family":"Dassi","sequence":"additional","affiliation":[{"name":"Laboratory of RNA Regulatory Networks, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento ,\u00a038123\u00a0 Trento , Italy"}]}],"member":"286","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"2023010804334531700_B1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.tibs.2020.11.001","article-title":"G-Quadruplexes in RNA biology: recent advances and future directions","volume":"46","author":"Dumas","year":"2021","journal-title":"Trends Biochem. 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