{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:56:57Z","timestamp":1783655817927,"version":"3.55.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22gm6310012h0003"],"award-info":[{"award-number":["JP22gm6310012h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cohesin is a multifunctional protein responsible for transcriptional regulation and chromatin organization. Cohesin binds to chromatin at tens of thousands of distinct sites in a conserved or tissue-specific manner, whereas the function of cohesin varies greatly depending on the epigenetic properties of specific chromatin loci. Cohesin also extensively mediates cis-regulatory modules (CRMs) and chromatin loops. Even though next-generation sequencing technologies have provided a wealth of information on different aspects of cohesin, the integration and exploration of the resultant massive cohesin datasets are not straightforward. Here, we present CohesinDB (https:\/\/cohesindb.iqb.u-tokyo.ac.jp), a comprehensive multiomics cohesin database in human cells. CohesinDB includes 2043 epigenomics, transcriptomics and 3D genomics datasets from 530 studies involving 176 cell types. By integrating these large-scale data, CohesinDB summarizes three types of \u2018cohesin objects\u2019: 751 590 cohesin binding sites, 957 868 cohesin-related chromatin loops and 2\u00a0229 500 cohesin-related CRMs. Each cohesin object is annotated with locus, cell type, classification, function, 3D genomics and cis-regulatory information. CohesinDB features a user-friendly interface for browsing, searching, analyzing, visualizing and downloading the desired information. CohesinDB contributes a valuable resource for all researchers studying cohesin, epigenomics, transcriptional regulation and chromatin organization.<\/jats:p>","DOI":"10.1093\/nar\/gkac795","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:08:38Z","timestamp":1664237318000},"page":"D70-D79","source":"Crossref","is-referenced-by-count":8,"title":["CohesinDB: a comprehensive database for decoding cohesin-related epigenomes, 3D genomes and transcriptomes in human cells"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3110-0605","authenticated-orcid":false,"given":"Jiankang","family":"Wang","sequence":"first","affiliation":[{"name":"Institute for Quantitative Biosciences, The University of Tokyo , Bunkyo-ku, Tokyo , Yayoi 1-1-1, Japan"},{"name":"Graduate School of Medicine, The University of Tokyo , Bunkyo-ku, Tokyo , Hongo 7-3-1, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichiro","family":"Nakato","sequence":"additional","affiliation":[{"name":"Institute for Quantitative Biosciences, The University of Tokyo , Bunkyo-ku, Tokyo , Yayoi 1-1-1, Japan"},{"name":"Graduate School of Medicine, The University of Tokyo , Bunkyo-ku, Tokyo , Hongo 7-3-1, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"2023010804313043500_B1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41568-020-0270-1","article-title":"Emerging themes in cohesin cancer biology","volume":"20","author":"Waldman","year":"2020","journal-title":"Nat. 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