{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:09:54Z","timestamp":1771049394033,"version":"3.50.1"},"reference-count":111,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ17H160009"],"award-info":[{"award-number":["LQ17H160009"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LR21H300001"],"award-info":[{"award-number":["LR21H300001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802371"],"award-info":[{"award-number":["81802371"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872798"],"award-info":[{"award-number":["81872798"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National High-Level Talents Special Support Plan of China"},{"name":"Fundamental Research Fund of Central University","award":["2018QNA7023"],"award-info":[{"award-number":["2018QNA7023"]}]},{"name":"Key R&D Program of Zhejiang Province","award":["2020C03010"],"award-info":[{"award-number":["2020C03010"]}]},{"name":"Chinese \u2018Double Top-Class\u2019 Universities","award":["181201*194232101"],"award-info":[{"award-number":["181201*194232101"]}]},{"name":"Start-up Grant of HZNU","award":["4125C5021720421"],"award-info":[{"award-number":["4125C5021720421"]}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201908330151"],"award-info":[{"award-number":["201908330151"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Westlake Laboratory"},{"name":"Future Digital Healthcare"},{"name":"Alibaba Cloud"},{"name":"Information Tech Center of Zhejiang University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>As the most prevalent internal modification in eukaryotic RNAs, N6-methyladenosine (m6A) has been discovered to play an essential role in cellular proliferation, metabolic homeostasis, embryonic development, etc. With the rapid accumulation of research interest in m6A, its crucial roles in the regulations of disease development and drug response are gaining more and more attention. Thus, a database offering such valuable data on m6A-centered regulation is greatly needed; however, no such database is as yet available. Herein, a new database named \u2018M6AREG\u2019 is developed to (i) systematically cover, for the first time, data on the effects of m6A-centered regulation on both disease development and drug response, (ii) explicitly describe the molecular mechanism underlying each type of regulation and (iii) fully reference the collected data by cross-linking to existing databases. Since the accumulated data are valuable for researchers in diverse disciplines (such as pathology and pathophysiology, clinical laboratory diagnostics, medicinal biochemistry and drug design), M6AREG is expected to have many implications for the future conduct of m6A-based regulation studies. It is currently accessible by all users at: https:\/\/idrblab.org\/m6areg\/<\/jats:p>","DOI":"10.1093\/nar\/gkac801","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T10:40:29Z","timestamp":1663843229000},"page":"D1333-D1344","source":"Crossref","is-referenced-by-count":24,"title":["M6AREG: m6A-centered regulation of disease development and drug response"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8831-7947","authenticated-orcid":false,"given":"Shuiping","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, Hangzhou Normal University , Hangzhou 311121, China"},{"name":"Laboratory of Cancer Genomics, Division of Cellular and Molecular Research , National Cancer Centre Singapore, Singapore 169610, Singapore"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, Hangzhou Normal University , Hangzhou 311121, China"}]},{"given":"Yintao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University , Hangzhou 310058, China"},{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare , Hangzhou 330110, China"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University , Hangzhou, 310000, China"}]},{"given":"Ying","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, Hangzhou Normal University , Hangzhou 311121, China"}]},{"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University , Hangzhou 310058, China"},{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare , Hangzhou 330110, China"}]},{"given":"Shasha","family":"Qi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, Hangzhou Normal University , Hangzhou 311121, China"}]},{"given":"Jinyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, Hangzhou Normal University , Hangzhou 311121, China"}]},{"given":"Xudong","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, Hangzhou Normal University , Hangzhou 311121, China"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, Hangzhou Normal University , Hangzhou 311121, China"}]},{"given":"Yongchao","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University , Hangzhou 310058, China"},{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare , Hangzhou 330110, China"}]},{"given":"Yunqing","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University , Hangzhou, 310000, China"}]},{"given":"Lin","family":"Tao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, Hangzhou Normal University , Hangzhou 311121, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8069-0053","authenticated-orcid":false,"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University , Hangzhou 310058, China"},{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare , Hangzhou 330110, China"}]}],"member":"286","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"2023010804211987700_B1","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1016\/j.cell.2021.03.062","article-title":"Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA 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Natl Acad. Sci. USA"},{"key":"2023010804211987700_B6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1021\/acs.jpclett.9b03399","article-title":"Large-scale biomolecular conformational transitions explored by a combined elastic network model and enhanced sampling molecular dynamics","volume":"11","author":"Wang","year":"2020","journal-title":"J. Phys. Chem. Lett."},{"key":"2023010804211987700_B7","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.ymthe.2020.08.010","article-title":"m6A RNA methylation in cardiovascular diseases","volume":"28","author":"Wu","year":"2020","journal-title":"Mol. Ther."},{"key":"2023010804211987700_B8","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.1038\/s41598-021-84007-0","article-title":"Evolutionary conservation of the DRACH signatures of potential N6-methyladenosine (m6A) sites among influenza A viruses","volume":"11","author":"Bayoumi","year":"2021","journal-title":"Sci. Rep."},{"key":"2023010804211987700_B9","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jcmgh.2020.07.001","article-title":"A new model of spontaneous colitis in mice induced by deletion of an RNA m6A methyltransferase component METTL14 in T cells","volume":"10","author":"Lu","year":"2020","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"2023010804211987700_B10","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.freeradbiomed.2022.02.028","article-title":"m6A methylation is required for dihydroartemisinin to alleviate liver fibrosis by inducing ferroptosis in hepatic stellate cells","volume":"182","author":"Shen","year":"2022","journal-title":"Free Radic. Biol. 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Transl. Med."},{"key":"2023010804211987700_B26","doi-asserted-by":"crossref","first-page":"bbab397","DOI":"10.1093\/bib\/bbab397","article-title":"RNA\u2013RNA interactions between SARS-CoV-2 and host benefit viral development and evolution during COVID-19 infection","volume":"23","author":"Zhang","year":"2021","journal-title":"Brief. Bioinform"},{"key":"2023010804211987700_B27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13045-020-00951-w","article-title":"Roles of METTL3 in cancer: mechanisms and therapeutic targeting","volume":"13","author":"Zeng","year":"2020","journal-title":"J. Hematol. 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