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Thus, synthesizing growing knowledge of cellular characteristics is critical for dissecting cellular heterogeneity, developmental processes and tumorigenesis at single-cell resolution. Here, we present Cell Taxonomy (https:\/\/ngdc.cncb.ac.cn\/celltaxonomy), a comprehensive and curated repository of cell types and associated cell markers encompassing a wide range of species, tissues and conditions. Combined with literature curation and data integration, the current version of Cell Taxonomy establishes a well-structured taxonomy for 3,143 cell types and houses a comprehensive collection of 26,613 associated cell markers in 257 conditions and 387 tissues across 34 species. Based on 4,299 publications and single-cell transcriptomic profiles of \u223c3.5 million cells, Cell Taxonomy features multifaceted characterization for cell types and cell markers, involving quality assessment of cell markers and cell clusters, cross-species comparison, cell composition of tissues and cellular similarity based on markers. Taken together, Cell Taxonomy represents a fundamentally useful reference to systematically and accurately characterize cell types and thus lays an important foundation for deeply understanding and exploring cellular biology in diverse species.<\/jats:p>","DOI":"10.1093\/nar\/gkac816","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T12:24:11Z","timestamp":1664022251000},"page":"D853-D860","source":"Crossref","is-referenced-by-count":60,"title":["Cell Taxonomy: a curated repository of cell types with multifaceted characterization"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6722-176X","authenticated-orcid":false,"given":"Shuai","family":"Jiang","sequence":"first","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing \u00a0100101,\u00a0 China"},{"name":"China National Center for Bioinformation , Beijing \u00a0100101,\u00a0 China"}]},{"given":"Qiheng","family":"Qian","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing \u00a0100101,\u00a0 China"},{"name":"China National Center for Bioinformation , Beijing \u00a0100101,\u00a0 China"},{"name":"University of Chinese Academy of Sciences , Beijing \u00a0100049,\u00a0 China"}]},{"given":"Tongtong","family":"Zhu","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing \u00a0100101,\u00a0 China"},{"name":"China National Center for Bioinformation , Beijing \u00a0100101,\u00a0 China"},{"name":"University of Chinese Academy of Sciences , Beijing \u00a0100049,\u00a0 China"}]},{"given":"Wenting","family":"Zong","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing \u00a0100101,\u00a0 China"},{"name":"China National Center for Bioinformation , Beijing \u00a0100101,\u00a0 China"},{"name":"University of Chinese Academy of Sciences , Beijing \u00a0100049,\u00a0 China"}]},{"given":"Yunfei","family":"Shang","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing \u00a0100101,\u00a0 China"},{"name":"China National Center for Bioinformation , Beijing \u00a0100101,\u00a0 China"},{"name":"University of Chinese Academy of Sciences , Beijing \u00a0100049,\u00a0 China"}]},{"given":"Tong","family":"Jin","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing \u00a0100101,\u00a0 China"},{"name":"China National Center for Bioinformation , Beijing \u00a0100101,\u00a0 China"},{"name":"University of Chinese Academy of Sciences , Beijing \u00a0100049,\u00a0 China"}]},{"given":"Yuansheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing \u00a0100101,\u00a0 China"},{"name":"China National Center for Bioinformation , Beijing \u00a0100101,\u00a0 China"},{"name":"University of Chinese Academy of Sciences , Beijing \u00a0100049,\u00a0 China"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing \u00a0100101,\u00a0 China"},{"name":"China National Center for Bioinformation , Beijing \u00a0100101,\u00a0 China"},{"name":"University of Chinese Academy of Sciences , Beijing \u00a0100049,\u00a0 China"}]},{"given":"Zishan","family":"Wu","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing \u00a0100101,\u00a0 China"},{"name":"China National Center for Bioinformation , Beijing \u00a0100101,\u00a0 China"},{"name":"University of Chinese Academy of Sciences , Beijing \u00a0100049,\u00a0 China"}]},{"given":"Yuan","family":"Chu","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing \u00a0100101,\u00a0 China"},{"name":"China National Center for Bioinformation , Beijing \u00a0100101,\u00a0 China"},{"name":"University of Chinese Academy of Sciences , Beijing \u00a0100049,\u00a0 China"}]},{"given":"Rongqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing \u00a0100101,\u00a0 China"},{"name":"China National Center for Bioinformation , Beijing \u00a0100101,\u00a0 China"},{"name":"University of Chinese Academy of Sciences , Beijing \u00a0100049,\u00a0 China"}]},{"given":"Sicheng","family":"Luo","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing \u00a0100101,\u00a0 China"},{"name":"China National Center for Bioinformation , Beijing \u00a0100101,\u00a0 China"},{"name":"University of Chinese Academy of Sciences , Beijing \u00a0100049,\u00a0 China"}]},{"given":"Wei","family":"Jing","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing \u00a0100101,\u00a0 China"},{"name":"China National Center for Bioinformation , Beijing \u00a0100101,\u00a0 China"},{"name":"University of Chinese Academy of Sciences , Beijing \u00a0100049,\u00a0 China"}]},{"given":"Dong","family":"Zou","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing \u00a0100101,\u00a0 China"},{"name":"China National Center for Bioinformation , Beijing \u00a0100101,\u00a0 China"}]},{"given":"Yiming","family":"Bao","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing 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