{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:08:24Z","timestamp":1782274104341,"version":"3.54.5"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","award":["C210812031"],"award-info":[{"award-number":["C210812031"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>AlloMAPS 2 is an update of the Allosteric Mutation Analysis and Polymorphism of Signalling database, which contains data on allosteric communication obtained for predicted structures in the AlphaFold database (AFDB) and trRosetta-predicted Pfam domains. The data update contains Allosteric Signalling Maps (ASMs) and Allosteric Probing Maps (APMs) quantifying allosteric effects of mutations and of small probe binding, respectively. To ensure quality of the ASMs and APMs, we performed careful and accurate selection of protein sets containing\u00a0high-quality predicted structures in both databases for each organism\/structure, and the data is available for browsing and download. The data for\u00a0remaining structures are available for download and should be used at user's discretion and responsibility. We believe these massive data can facilitate both diagnostics and drug design within the precision medicine paradigm.\u00a0Specifically, it can\u00a0be instrumental in the analysis of allosteric effects of pathological and rescue mutations, providing starting points for fragment-based design of allosteric effectors. The exhaustive character of allosteric signalling and probing fingerprints will be also\u00a0useful in future developments of corresponding machine learning applications. The database is\u00a0freely available at: http:\/\/allomaps.bii.a-star.edu.sg.<\/jats:p>","DOI":"10.1093\/nar\/gkac828","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T12:15:16Z","timestamp":1664367316000},"page":"D345-D351","source":"Crossref","is-referenced-by-count":27,"title":["AlloMAPS 2: allosteric fingerprints of the AlphaFold and Pfam-trRosetta predicted structures for engineering and design"],"prefix":"10.1093","volume":"51","author":[{"given":"Zhen Wah","family":"Tan","sequence":"first","affiliation":[{"name":"Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR) , 30 Biopolis Street, #07-01, Matrix, 138671 , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ven","family":"Tee","sequence":"additional","affiliation":[{"name":"Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR) , 30 Biopolis Street, #07-01, Matrix, 138671 , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Guarnera","sequence":"additional","affiliation":[{"name":"Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR) , 30 Biopolis Street, #07-01, Matrix, 138671 , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3315-8483","authenticated-orcid":false,"given":"Igor N","family":"Berezovsky","sequence":"additional","affiliation":[{"name":"Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR) , 30 Biopolis Street, #07-01, Matrix, 138671 , Singapore"},{"name":"Department of Biological Sciences (DBS), National University of Singapore (NUS) , 8 Medical Drive, 117579 , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"2023010804240174800_B1","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.str.2019.01.003","article-title":"Allostery in its many disguises: from theory to applications","volume":"27","author":"Wodak","year":"2019","journal-title":"Structure"},{"key":"2023010804240174800_B2","doi-asserted-by":"crossref","first-page":"167751","DOI":"10.1016\/j.jmb.2022.167751","article-title":"Multiscale allostery: basic mechanisms and versatility in diagnostics and drug design","volume":"434","author":"Berezovsky","year":"2022","journal-title":"J. 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