{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T17:54:23Z","timestamp":1776794063598,"version":"3.51.2"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Scientific Foundation of China","doi-asserted-by":"crossref","award":["62171241"],"award-info":[{"award-number":["62171241"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Scientific Foundation of China","doi-asserted-by":"crossref","award":["62061034"],"award-info":[{"award-number":["62061034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Scientific Foundation of China","doi-asserted-by":"crossref","award":["61861036"],"award-info":[{"award-number":["61861036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Scientific Foundation of China","doi-asserted-by":"crossref","award":["62161039"],"award-info":[{"award-number":["62161039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"key technology research program of Inner Mongolia Autonomous Region","award":["2021GG0398"],"award-info":[{"award-number":["2021GG0398"]}]},{"name":"Science and Technology Major Project of Inner Mongolia Autonomous Region of China to the State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock","award":["2019ZD031"],"award-info":[{"award-number":["2019ZD031"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The emerging importance of embryonic development research rapidly increases the volume for a professional resource related to multi-omics data. However, the lack of global embryogenesis repository and systematic analysis tools limits the preceding in stem cell research, human congenital diseases and assisted reproduction. Here, we developed the EmAtlas, which collects the most comprehensive multi-omics data and provides multi-scale tools to explore spatiotemporal activation during mammalian embryogenesis. EmAtlas contains data on multiple types of gene expression, chromatin accessibility, DNA methylation, nucleosome occupancy, histone modifications, and transcription factors, which displays the complete spatiotemporal landscape in mouse and human across several time points, involving gametogenesis, preimplantation, even fetus and neonate, and each tissue involves various cell types. To characterize signatures involved in the tissue, cell, genome, gene and protein levels during mammalian embryogenesis, analysis tools on these five scales were developed. Additionally, we proposed EmRanger to deliver extensive development-related biological background annotations. Users can utilize these tools to analyze, browse, visualize, and download data owing to the user-friendly interface. EmAtlas is freely accessible at http:\/\/bioinfor.imu.edu.cn\/ematlas.<\/jats:p>","DOI":"10.1093\/nar\/gkac848","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T12:30:17Z","timestamp":1664800217000},"page":"D924-D932","source":"Crossref","is-referenced-by-count":28,"title":["EmAtlas: a comprehensive atlas for exploring spatiotemporal activation in mammalian embryogenesis"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8531-6949","authenticated-orcid":false,"given":"Lei","family":"Zheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University , Hohhot, 010070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University , Hohhot, 010070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunshen","family":"Long","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University , Hohhot, 010070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haicheng","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University , Hohhot, 010070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanshuang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University , Hohhot, 010070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchao","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University , Hohhot, 010070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University , Hohhot, 010070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qilemuge","family":"Xi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University , Hohhot, 010070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqiang","family":"Xing","sequence":"additional","affiliation":[{"name":"The Inner Mongolia Key Laboratory of Functional Genome Bioinformatics, School of Life Science and Technology, Inner Mongolia University of Science and Technology , Baotou, 014010 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-7835","authenticated-orcid":false,"given":"Yongchun","family":"Zuo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University , Hohhot, 010070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"2023010804323573400_B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gde.2018.04.005","article-title":"Functional genetics of early human development","volume":"52","author":"Ortega","year":"2018","journal-title":"Curr. 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