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However, a comprehensive database that systematically collects and classifies the scattered data is still lacking. Here, we developed the Rheumatoid Arthritis Bioinformatics Center (RABC, http:\/\/www.onethird-lab.com\/RABC\/),\u00a0the first multi-omics data resource platform (data hub) for RA. There are four categories of data in RABC: (i) 175 multi-omics sample sets covering transcriptome, epigenome, genome, and proteome; (ii) 175 209 differentially expressed genes (DEGs), 105 differentially expressed microRNAs (DEMs), 18 464 differentially DNA methylated (DNAm) genes, 1\u00a0764 KEGG pathways, 30 488 GO terms, 74 334 SNPs, 242 779 eQTLs, 105 m6A-SNPs and 18 491 669 meta-mQTLs; (iii) prior knowledge on seven types of RA molecular markers from nine public and credible databases; (iv) 127 073 literature information from PubMed (from 1972 to March 2022). RABC provides a user-friendly interface for browsing, searching and downloading these data. In addition, a visualization module also supports users to generate graphs of analysis results by inputting personalized parameters. We believe that RABC will become a valuable resource and make a significant contribution to the study of RA.<\/jats:p>","DOI":"10.1093\/nar\/gkac850","type":"journal-article","created":{"date-parts":[[2022,10,16]],"date-time":"2022-10-16T09:57:06Z","timestamp":1665914226000},"page":"D1381-D1387","source":"Crossref","is-referenced-by-count":10,"title":["RABC: Rheumatoid Arthritis Bioinformatics Center"],"prefix":"10.1093","volume":"51","author":[{"given":"Haiyan","family":"Chen","sequence":"first","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"},{"name":"The ABC Project , Harbin , China"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"},{"name":"The ABC Project , Harbin , China"}]},{"given":"Siyu","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"},{"name":"The ABC Project , Harbin , China"}]},{"given":"Zhe","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"},{"name":"The ABC Project , Harbin , China"}]},{"given":"Chen","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"},{"name":"The ABC Project , Harbin , China"}]},{"given":"Jingxuan","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"},{"name":"The ABC Project , Harbin , China"}]},{"given":"Xuying","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"}]},{"given":"Junxian","family":"Tao","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"},{"name":"The ABC Project , Harbin , China"}]},{"given":"Yu","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"},{"name":"The ABC Project , Harbin , China"}]},{"given":"Yingnan","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"}]},{"given":"Wenhua","family":"Lv","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"}]},{"given":"Hongsheng","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"}]},{"given":"Shuo","family":"Bi","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"}]},{"given":"Hongchao","family":"Lv","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"}]},{"given":"Chen","family":"Huang","sequence":"additional","affiliation":[{"name":"Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, Macau University of Science and Technology , Macau, SAR , China"},{"name":"Stat Key laboratory of Quality Research in Chinese Medicine, Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology , Macau, SAR , China"}]},{"given":"Fanwu","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Second Affiliated Hospital, Harbin Medical University , Harbin , China"}]},{"given":"Guoping","family":"Tang","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital, Zhejiang University School of Medicine , Yiwu , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7163-6554","authenticated-orcid":false,"given":"Yongshuai","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"},{"name":"The ABC Project , Harbin , China"}]},{"given":"Mingming","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China"},{"name":"The ABC Project , Harbin , China"}]}],"member":"286","published-online":{"date-parts":[[2022,10,16]]},"reference":[{"key":"2023010804184750200_B1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00296-020-04731-0","article-title":"The global prevalence of rheumatoid arthritis: a meta-analysis based on a systematic review","volume":"41","author":"Almutairi","year":"2021","journal-title":"Rheumatol. Int."},{"key":"2023010804184750200_B2","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"2023010804184750200_B3","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.3390\/cells10112857","article-title":"Management of rheumatoid arthritis: an overview","volume":"10","author":"Radu","year":"2021","journal-title":"Cells"},{"key":"2023010804184750200_B4","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nrrheum.2014.64","article-title":"Mechanisms, impact and management of pain in rheumatoid arthritis","volume":"10","author":"Walsh","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"2023010804184750200_B5","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1136\/annrheumdis-2013-204627","article-title":"The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study","volume":"73","author":"Cross","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"2023010804184750200_B6","first-page":"Cp4","article-title":"Big data in biomedicine","volume":"527","author":"Bender","year":"2015","journal-title":"Nature"},{"key":"2023010804184750200_B7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1136\/bmj.324.7332.264","article-title":"Relative importance of genetic effects in rheumatoid arthritis: historical cohort study of danish nationwide twin population","volume":"324","author":"Svendsen","year":"2002","journal-title":"BMJ"},{"key":"2023010804184750200_B8","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/art.24385","article-title":"Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis","volume":"60","author":"van\u00a0der\u00a0Woude","year":"2009","journal-title":"Arthritis Rheum."},{"key":"2023010804184750200_B9","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1136\/annrheumdis-2012-202743","article-title":"The potential use of expression profiling: implications for predicting treatment response in rheumatoid arthritis","volume":"72","author":"Smith","year":"2013","journal-title":"Ann. 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