{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:14:45Z","timestamp":1774617285954,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Tou-Yan Innovation Team Program of the Heilongjiang Province","award":["2019-15"],"award-info":[{"award-number":["2019-15"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62222104"],"award-info":[{"award-number":["62222104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61871160"],"award-info":[{"award-number":["61871160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62172130"],"award-info":[{"award-number":["62172130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heilongjiang Postdoctoral Fund","award":["LBH-Q20030"],"award-info":[{"award-number":["LBH-Q20030"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gut microbiota plays a significant role in maintaining host health, and conversely, disorders potentially lead to dysbiosis, an imbalance in the composition of the gut microbial community. Intervention approaches, such as medications, diets, and several others, also alter the gut microbiota in either a beneficial or harmful direction. In 2020, the gutMDisorder was developed to facilitate researchers in the investigation of dysbiosis of gut microbes as occurs in various disorders as well as with therapeutic interventions. The database has been updated this year, following revision of previous publications and newly published reports to manually integrate confirmed associations under multitudinous conditions. Additionally, the microbial contents of downloaded gut microbial raw sequencing data were annotated, the metadata of the corresponding hosts were manually curated, and the interactive charts were developed to enhance visualization. The improvements have assembled into gutMDisorder v2.0, a more advanced search engine and an upgraded web interface, which can be freely accessed via http:\/\/bio-annotation.cn\/gutMDisorder\/.<\/jats:p>","DOI":"10.1093\/nar\/gkac871","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T20:26:49Z","timestamp":1665433609000},"page":"D717-D722","source":"Crossref","is-referenced-by-count":48,"title":["gutMDisorder v2.0: a comprehensive database for dysbiosis of gut microbiota in phenotypes and interventions"],"prefix":"10.1093","volume":"51","author":[{"given":"Changlu","family":"Qi","sequence":"first","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , Heilongjiang , China"}]},{"given":"Yiting","family":"Cai","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , Heilongjiang , China"}]},{"given":"Kai","family":"Qian","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , Heilongjiang , China"}]},{"given":"Xuefeng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , Heilongjiang , China"}]},{"given":"Jialiang","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , Heilongjiang , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4451-1585","authenticated-orcid":false,"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , Heilongjiang , China"}]},{"given":"Tongze","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , Heilongjiang , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1913-081X","authenticated-orcid":false,"given":"Tianyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Medicine and Health, Harbin Institute of Technology , Harbin 150001 , Heilongjiang , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6665-6710","authenticated-orcid":false,"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , Heilongjiang , China"},{"name":"NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, Harbin Medical University , Harbin 150028 , Heilongjiang , China"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, Harbin Medical University , Harbin 150028 , Heilongjiang , China"}]},{"given":"Xue","family":"Zhang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, Harbin Medical University , Harbin 150028 , Heilongjiang , China"},{"name":"McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100005 , China"}]}],"member":"286","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"2023010804204083400_B1","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem. J."},{"key":"2023010804204083400_B2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cmet.2017.05.008","article-title":"Understanding the holobiont: how microbial metabolites affect human health and shape the immune system","volume":"26","author":"Postler","year":"2017","journal-title":"Cell Metab."},{"key":"2023010804204083400_B3","doi-asserted-by":"crossref","first-page":"D795","DOI":"10.1093\/nar\/gkab786","article-title":"gutMGene: a comprehensive database for target genes of gut microbes and microbial metabolites","volume":"50","author":"Cheng","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2023010804204083400_B4","doi-asserted-by":"crossref","first-page":"j831","DOI":"10.1136\/bmj.j831","article-title":"The role of the microbiome in human health and disease: an introduction for clinicians","volume":"356","author":"Young","year":"2017","journal-title":"BMJ"},{"key":"2023010804204083400_B5","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.1038\/s41467-020-18871-1","article-title":"Health and disease markers correlate with gut microbiome composition across thousands of people","volume":"11","author":"Manor","year":"2020","journal-title":"Nat. Commun."},{"key":"2023010804204083400_B6","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/advances\/nmab077","article-title":"Fueling gut microbes: a review of the interaction between diet, exercise, and the gut microbiota in athletes","volume":"12","author":"Hughes","year":"2021","journal-title":"Adv. Nutr."},{"key":"2023010804204083400_B7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/bfgp\/elaa029","article-title":"A comprehensive review for gut microbes: technologies, interventions, metabolites and diseases","volume":"20","author":"Qi","year":"2021","journal-title":"Brief. Funct. Genomics"},{"key":"2023010804204083400_B8","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s12275-018-8238-5","article-title":"Progress of analytical tools and techniques for human gut microbiome research","volume":"56","author":"Song","year":"2018","journal-title":"J. Microbiol."},{"key":"2023010804204083400_B9","doi-asserted-by":"crossref","first-page":"bbaa158","DOI":"10.1093\/bib\/bbaa158","article-title":"Microbes and complex diseases: from experimental results to computational models","volume":"22","author":"Zhao","year":"2021","journal-title":"Brief Bioinform"},{"key":"2023010804204083400_B10","doi-asserted-by":"crossref","first-page":"D554","DOI":"10.1093\/nar\/gkz843","article-title":"gutMDisorder: a comprehensive database for dysbiosis of the gut microbiota in disorders and interventions","volume":"48","author":"Cheng","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2023010804204083400_B11","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.3748\/wjg.v24.i13.1464","article-title":"Fecal microbial dysbiosis in Chinese patients with inflammatory bowel disease","volume":"24","author":"Ma","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"2023010804204083400_B12","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/hep.31523","article-title":"The commensal microbe veillonella as a marker for response to an FGF19 Analog in NASH","volume":"73","author":"Loomba","year":"2021","journal-title":"Hepatology"},{"key":"2023010804204083400_B13","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3390\/nu10091255","article-title":"Lactobacillus acidophilus DDS-1 modulates the gut microbiota and improves metabolic profiles in aging mice","volume":"10","author":"Vemuri","year":"2018","journal-title":"Nutrients"},{"key":"2023010804204083400_B14","doi-asserted-by":"crossref","first-page":"D54","DOI":"10.1093\/nar\/gkr854","article-title":"The sequence read archive: explosive growth of sequencing data","volume":"40","author":"Kodama","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2023010804204083400_B15","doi-asserted-by":"crossref","first-page":"D11","DOI":"10.1093\/nar\/gkab1127","article-title":"The European Bioinformatics Institute (EMBL-EBI) in 2021","volume":"50","author":"Cantelli","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2023010804204083400_B16","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"2023010804204083400_B17","doi-asserted-by":"crossref","first-page":"e65088","DOI":"10.7554\/eLife.65088","article-title":"Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3","volume":"10","author":"Beghini","year":"2021","journal-title":"Elife"},{"key":"2023010804204083400_B18","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"2023010804204083400_B19","doi-asserted-by":"crossref","first-page":"baaa062","DOI":"10.1093\/database\/baaa062","article-title":"NCBI taxonomy: a comprehensive update on curation, resources and tools","volume":"2020","author":"Schoch","year":"2020","journal-title":"Database (Oxford)"},{"key":"2023010804204083400_B20","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/1471-2105-12-385","article-title":"Interactive metagenomic visualization in a Web browser","volume":"12","author":"Ondov","year":"2011","journal-title":"BMC Bioinf."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/51\/D1\/D717\/48440681\/gkac871.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/51\/D1\/D717\/48440681\/gkac871.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T04:21:10Z","timestamp":1673151670000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/51\/D1\/D717\/6754909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,10]]},"references-count":20,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2022,10,10]]},"published-print":{"date-parts":[[2023,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkac871","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,6]]},"published":{"date-parts":[[2022,10,10]]}}}