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However, there is a lack of databases for users to access and analyze spatial omics data. To address this limitation, we developed Aquila, a comprehensive platform for managing and analyzing spatial omics data. Aquila contains 107 datasets from 30 diseases, including 6500+\u00a0regions of interest, and 15.7 million cells. The database covers studies from spatial transcriptome and proteome analyses, 2D and 3D experiments, and different technologies. Aquila provides visualization of spatial omics data in multiple formats such as spatial cell distribution, spatial expression and co-localization of markers. Aquila also lets users perform many basic and advanced spatial analyses on any dataset. In addition, users can submit their own spatial omics data for visualization and analysis in a safe and secure environment. Finally, Aquila can be installed as an individual app on a desktop and offers the RESTful API service for power users to access the database. Overall, Aquila provides a detailed insight into transcript and protein expression in tissues from a spatial perspective. Aquila is available at https:\/\/aquila.cheunglab.org.<\/jats:p>","DOI":"10.1093\/nar\/gkac874","type":"journal-article","created":{"date-parts":[[2022,10,16]],"date-time":"2022-10-16T09:58:16Z","timestamp":1665914296000},"page":"D827-D834","source":"Crossref","is-referenced-by-count":33,"title":["Aquila: a spatial omics database and analysis platform"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0394-9735","authenticated-orcid":false,"given":"Yimin","family":"Zheng","sequence":"first","affiliation":[{"name":"Cancer Centre, University of Macau , Taipa 999078, Macau SAR"},{"name":"Centre for Precision Medicine Research and Training, University of Macau , Taipa 999078, Macau SAR"},{"name":"MoE Frontiers Science Center for Precision Oncology, University of Macau , Taipa 999078, Macau SAR"},{"name":"Faculty of Health Sciences, University of Macau , Taipa 999078, Macau SAR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6159-8160","authenticated-orcid":false,"given":"Yitian","family":"Chen","sequence":"additional","affiliation":[{"name":"Cancer Centre, University of Macau , Taipa 999078, Macau SAR"},{"name":"Centre for Precision Medicine Research and Training, University of Macau , Taipa 999078, Macau SAR"},{"name":"MoE Frontiers Science Center for Precision Oncology, University of Macau , Taipa 999078, Macau SAR"},{"name":"Faculty of Health Sciences, University of Macau , Taipa 999078, Macau SAR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1549-3499","authenticated-orcid":false,"given":"Xianting","family":"Ding","sequence":"additional","affiliation":[{"name":"Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University , Shanghai 200240 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9264-5118","authenticated-orcid":false,"given":"Koon Ho","family":"Wong","sequence":"additional","affiliation":[{"name":"Cancer Centre, University of Macau , Taipa 999078, Macau SAR"},{"name":"Centre for Precision Medicine Research and Training, University of Macau , Taipa 999078, Macau SAR"},{"name":"MoE Frontiers Science Center for Precision Oncology, University of Macau , Taipa 999078, Macau SAR"},{"name":"Faculty of Health Sciences, University of Macau , Taipa 999078, Macau SAR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-2833","authenticated-orcid":false,"given":"Edwin","family":"Cheung","sequence":"additional","affiliation":[{"name":"Cancer Centre, University of Macau , Taipa 999078, Macau SAR"},{"name":"Centre for Precision Medicine Research and Training, University of Macau , Taipa 999078, Macau SAR"},{"name":"MoE Frontiers Science Center for Precision Oncology, University of Macau , Taipa 999078, Macau SAR"},{"name":"Faculty of Health Sciences, University of Macau , Taipa 999078, Macau SAR"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,16]]},"reference":[{"key":"2023010804231376300_B1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41586-019-1629-x","article-title":"The human body at cellular resolution: the NIH Human Biomolecular Atlas Program","volume":"574","author":"HuBMAP Consortium","year":"2019","journal-title":"Nature"},{"key":"2023010804231376300_B2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev-biodatasci-080917-013452","article-title":"From tissues to cell types and back: single-cell gene expression analysis of tissue architecture","volume":"1","author":"Chen","year":"2018","journal-title":"Annu. 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