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These include primary metabolites, secondary metabolites, natural products, food chemicals, synthetic food additives, drugs, herbicides, pesticides and environmental chemicals. ChemFOnt is a FAIR-compliant resource intended to bring the same rigor, standardization and formal structure to the terms and terminology used in biochemistry, food chemistry and environmental chemistry as the gene ontology (GO) has brought to molecular biology. ChemFOnt is available as both a freely accessible, web-enabled database and a downloadable Web Ontology Language (OWL) file. Users may download and deploy ChemFOnt within their own chemical databases or integrate ChemFOnt into their own analytical software to generate machine readable relationships that can be used to make new inferences, enrich their omics data sets or make new, non-obvious connections between chemicals and their direct or indirect effects. The web version of the ChemFOnt database has been designed to be easy to search, browse and navigate. Currently ChemFOnt contains data on 341 627 chemicals, including 515 332 terms or definitions. The functional hierarchy for ChemFOnt consists of four functional \u2018aspects\u2019, 12 functional super-categories and a total of 173 705 functional terms. In addition, each of the chemicals are classified into 4825 structure-based chemical classes. ChemFOnt currently contains 3.9 million protein-chemical relationships and \u223c10.3 million chemical-functional relationships. The long-term goal for ChemFOnt is for it to be adopted by databases and software tools used by the general chemistry community as well as the metabolomics, exposomics, metagenomics, genomics and proteomics communities.<\/jats:p>","DOI":"10.1093\/nar\/gkac919","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T15:38:34Z","timestamp":1666971514000},"page":"D1220-D1229","source":"Crossref","is-referenced-by-count":18,"title":["ChemFOnt: the chemical functional ontology resource"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3207-2434","authenticated-orcid":false,"given":"David S","family":"Wishart","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Alberta , Edmonton , AB \u00a0T6G 2E9, Canada"},{"name":"Department of Computing Science, University of Alberta , Edmonton , AB \u00a0T6G 2E8, Canada"},{"name":"Department of Laboratory Medicine and Pathology, University of Alberta , Edmonton , AB \u00a0T6G 2B7, Canada"},{"name":"Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta , Edmonton , AB \u00a0T6G 2H7, Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8667-0907","authenticated-orcid":false,"given":"Sagan","family":"Girod","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta , Edmonton , AB \u00a0T6G 2E9, Canada"}]},{"given":"Harrison","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta , Edmonton , AB \u00a0T6G 2E9, Canada"}]},{"given":"Eponine","family":"Oler","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta , Edmonton , AB \u00a0T6G 2E9, Canada"}]},{"given":"Juan","family":"Jovel","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta , Edmonton , AB \u00a0T6G 2E9, Canada"}]},{"given":"Zachary","family":"Budinski","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta , Edmonton , AB \u00a0T6G 2E9, Canada"}]},{"given":"Ralph","family":"Milford","sequence":"additional","affiliation":[{"name":"Department of Computing Science, University of Alberta , Edmonton , AB \u00a0T6G 2E8, Canada"}]},{"given":"Vicki W","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta , Edmonton , AB \u00a0T6G 2E9, Canada"}]},{"given":"Zinat","family":"Sayeeda","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta , Edmonton , AB \u00a0T6G 2E9, Canada"}]},{"given":"Robert","family":"Mah","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta , Edmonton , AB \u00a0T6G 2E9, Canada"}]},{"given":"William","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta , Edmonton , AB \u00a0T6G 2E9, Canada"}]},{"given":"Hasan","family":"Badran","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta , Edmonton , AB \u00a0T6G 2E9, Canada"}]},{"given":"Elvis","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta , Edmonton , AB \u00a0T6G 2E9, Canada"}]},{"given":"Mai","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Molecular You Corporation , 788 Beatty St., Suite 307 , Vancouver , BC \u00a0V6B 2M1, Canada"}]},{"given":"Yannick","family":"Djoumbou-Feunang","sequence":"additional","affiliation":[{"name":"Corteva Agriscience , Indianapolis , IN \u00a046268, USA"}]},{"given":"Naama","family":"Karu","sequence":"additional","affiliation":[{"name":"Leiden Academic Centre for Drug Research, Leiden University , Leiden , 2333 CC , The Netherlands"}]},{"given":"Vasuk","family":"Gautam","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta , Edmonton , AB \u00a0T6G 2E9, Canada"}]}],"member":"286","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"2023010804290066700_B1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/0470857897.ch6","article-title":"On ontologies for biologists: the gene ontology - Untangling the web","volume-title":"In Silico\u2019 Simulation of Biological Processes Novartis Foundation Symposium 247","author":"Ashburner","year":"2002"},{"key":"2023010804290066700_B2","doi-asserted-by":"crossref","first-page":"e1000431","DOI":"10.1371\/journal.pcbi.1000431","article-title":"The gene ontology's reference genome project: a unified framework for functional annotation across species","volume":"5","author":"Gaudet","year":"2009","journal-title":"PLoS Comput. 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