{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:02:47Z","timestamp":1787896967918,"version":"build-2784847793"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010803","name":"Department of Biotechnology","doi-asserted-by":"publisher","award":["RA\/1121\/09-2021"],"award-info":[{"award-number":["RA\/1121\/09-2021"]}],"id":[{"id":"10.13039\/501100010803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["BT\/PR40165\/BTIS\/137\/12\/2021"],"award-info":[{"award-number":["BT\/PR40165\/BTIS\/137\/12\/2021"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>There has been an exponential increase in the design of synthetic antimicrobial peptides (AMPs) for its use as novel antibiotics. Synthetic AMPs are substantially enriched in residues with physicochemical properties known to be critical for antimicrobial activity; such as positive charge, hydrophobicity, and higher alpha helical propensity. The current prediction algorithms for AMPs have been developed using AMP sequences from natural sources and hence do not perform well for synthetic peptides. In this version of CAMP database, along with updating sequence information of AMPs, we have created separate prediction algorithms for natural and synthetic AMPs. CAMPR4 holds 24243 AMP sequences, 933 structures, 2143 patents and 263 AMP family signatures. In addition to the data on sequences, source organisms, target organisms, minimum inhibitory and hemolytic concentrations, CAMPR4 provides information on N and C terminal modifications and presence of unusual amino acids, as applicable. The database is integrated with tools for AMP prediction and rational design (natural and synthetic AMPs), sequence (BLAST and clustal omega), structure (VAST) and family analysis (PRATT, ScanProsite, CAMPSign). The data along with the algorithms of CAMPR4 will aid to enhance AMP research. CAMPR4 is accessible at http:\/\/camp.bicnirrh.res.in\/.<\/jats:p>","DOI":"10.1093\/nar\/gkac933","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T08:51:56Z","timestamp":1665478316000},"page":"D377-D383","source":"Crossref","is-referenced-by-count":279,"title":["CAMPR4: a database of natural and synthetic antimicrobial peptides"],"prefix":"10.1093","volume":"51","author":[{"given":"Ulka","family":"Gawde","sequence":"first","affiliation":[{"name":"Biomedical Informatics Centre, ICMR-National Institute for Research in Reproductive and Child Health , Mumbai \u00a0400012,\u00a0 Maharashtra , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuvechha","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Centre, ICMR-National Institute for Research in Reproductive and Child Health , Mumbai \u00a0400012,\u00a0 Maharashtra , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiza Hanif","family":"Waghu","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Centre, ICMR-National Institute for Research in Reproductive and Child Health , Mumbai \u00a0400012,\u00a0 Maharashtra , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram Shankar","family":"Barai","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Centre, ICMR-National Institute for Research in Reproductive and Child Health , Mumbai \u00a0400012,\u00a0 Maharashtra , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashlesha","family":"Khanderkar","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Guru Nanak Khalsa College , Nathalal Parekh Marg, Matunga , Mumbai \u00a0400019,\u00a0 Maharashtra , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishikesh","family":"Indraguru","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Guru Nanak Khalsa College , Nathalal Parekh Marg, Matunga , Mumbai \u00a0400019,\u00a0 Maharashtra , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanmay","family":"Shirsat","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Centre, ICMR-National Institute for Research in Reproductive and Child Health , Mumbai \u00a0400012,\u00a0 Maharashtra , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3766-6757","authenticated-orcid":false,"given":"Susan","family":"Idicula-Thomas","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Centre, ICMR-National Institute for Research in Reproductive and Child Health , Mumbai \u00a0400012,\u00a0 Maharashtra , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"key":"2023010804315992300_B1","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.2147\/IDR.S173867","article-title":"Antibiotic resistance: a rundown of a global crisis","volume":"11","author":"Aslam","year":"2018","journal-title":"Infect. Drug Resist."},{"key":"2023010804315992300_B2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ijid.2020.12.087","article-title":"Antibiotics and antimicrobial resistance in the COVID-19 era: perspective from resource-limited settings","volume":"104","author":"Lucien","year":"2021","journal-title":"Int. J. Infect. Dis."},{"key":"2023010804315992300_B3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/415389a","article-title":"Antimicrobial peptides of multicellular organisms","volume":"415","author":"Zasloff","year":"2002","journal-title":"Nature"},{"key":"2023010804315992300_B4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3389\/fmicb.2018.00325","article-title":"Designing antibacterial peptides with enhanced killing kinetics","volume":"9","author":"Waghu","year":"2018","journal-title":"Front. Microbiol."},{"key":"2023010804315992300_B5","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1038\/s41467-019-12364-6","article-title":"Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance","volume":"10","author":"Spohn","year":"2019","journal-title":"Nat. Commun."},{"key":"2023010804315992300_B6","doi-asserted-by":"crossref","first-page":"e54908","DOI":"10.1371\/journal.pone.0054908","article-title":"HIPdb: a database of experimentally validated HIV inhibiting peptides","volume":"8","author":"Qureshi","year":"2013","journal-title":"PLoS One"},{"key":"2023010804315992300_B7","doi-asserted-by":"crossref","first-page":"D288","DOI":"10.1093\/nar\/gkaa991","article-title":"DBAASP v3: database of antimicrobial\/cytotoxic activity and structure of peptides as a resource for development of new therapeutics","volume":"49","author":"Pirtskhalava","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2023010804315992300_B8","doi-asserted-by":"crossref","first-page":"D1087","DOI":"10.1093\/nar\/gkv1278","article-title":"APD3: the antimicrobial peptide database as a tool for research and education","volume":"44","author":"Wang","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2023010804315992300_B9","doi-asserted-by":"crossref","first-page":"D460","DOI":"10.1093\/nar\/gkab1080","article-title":"dbAMP 2.0: updated resource for antimicrobial peptides with an enhanced scanning method for genomic and proteomic data","volume":"50","author":"Jhong","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2023010804315992300_B10","doi-asserted-by":"crossref","first-page":"baaa061","DOI":"10.1093\/database\/baaa061","article-title":"LAMP2: a major update of the database linking antimicrobial peptides","volume":"2020","author":"Ye","year":"2020","journal-title":"Database"},{"key":"2023010804315992300_B11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/08927014.2015.1021340","article-title":"BaAMPs: the database of biofilm-active antimicrobial peptides","volume":"31","author":"Di\u00a0Luca","year":"2015","journal-title":"Biofouling"},{"key":"2023010804315992300_B12","doi-asserted-by":"crossref","first-page":"D1147","DOI":"10.1093\/nar\/gkt1191","article-title":"AVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses","volume":"42","author":"Qureshi","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2023010804315992300_B13","doi-asserted-by":"crossref","first-page":"D774","DOI":"10.1093\/nar\/gkp1021","article-title":"CAMP: a useful resource for research on antimicrobial peptides","volume":"38","author":"Thomas","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2023010804315992300_B14","doi-asserted-by":"crossref","first-page":"D1154","DOI":"10.1093\/nar\/gkt1157","article-title":"CAMP: collection of sequences and structures of antimicrobial peptides","volume":"42","author":"Waghu","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2023010804315992300_B15","doi-asserted-by":"crossref","first-page":"D1094","DOI":"10.1093\/nar\/gkv1051","article-title":"CampR3: a database on sequences, structures and signatures of antimicrobial peptides","volume":"44","author":"Waghu","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2023010804315992300_B16","first-page":"475062","article-title":"A large-scale structural classification of antimicrobial peptides","volume":"2015","author":"Lee","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"2023010804315992300_B17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jgar.2016.10.003","article-title":"InverPep: a database of invertebrate antimicrobial peptides","volume":"8","author":"G\u00f3mez","year":"2017","journal-title":"J. Global Antimicrob. Resist."},{"key":"2023010804315992300_B18","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ijantimicag.2011.12.003","article-title":"YADAMP: yet another database of antimicrobial peptides","volume":"39","author":"Piotto","year":"2012","journal-title":"Int. J. Antimicrob. Agents"},{"key":"2023010804315992300_B19","doi-asserted-by":"crossref","first-page":"e66557","DOI":"10.1371\/journal.pone.0066557","article-title":"LAMP: a database linking antimicrobial peptides","volume":"8","author":"Zhao","year":"2013","journal-title":"PLoS One"},{"key":"2023010804315992300_B20","doi-asserted-by":"crossref","first-page":"e79728","DOI":"10.1371\/journal.pone.0079728","article-title":"C-PAmP: large scale analysis and database construction containing high scoring computationally predicted antimicrobial peptides for all the available plant species","volume":"8","author":"Niarchou","year":"2013","journal-title":"PLoS One"},{"key":"2023010804315992300_B21","doi-asserted-by":"crossref","first-page":"D444","DOI":"10.1093\/nar\/gkt1008","article-title":"Hemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides","volume":"42","author":"Gautam","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2023010804315992300_B22","doi-asserted-by":"crossref","first-page":"D285","DOI":"10.1093\/nar\/gky1030","article-title":"dbAMP: an integrated resource for exploring antimicrobial peptides with functional activities and physicochemical properties on transcriptome and proteome data","volume":"47","author":"Jhong","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2023010804315992300_B23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00203-016-1293-6","article-title":"ANTISTAPHYBASE: database of antimicrobial peptides (AMPs) and essential oils (Eos) against methicillin-resistant staphylococcus aureus (MRSA) and staphylococcus aureus","volume":"199","author":"Zouhir","year":"2017","journal-title":"Arch. Microbiol."},{"key":"2023010804315992300_B24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12602-016-9215-0","article-title":"Development of antimicrobial peptide prediction tool for aquaculture industries","volume":"8","author":"Gautam","year":"2016","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"2023010804315992300_B25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.compag.2014.12.008","article-title":"Species specific approach to the development of web-based antimicrobial peptides prediction tool for cattle","volume":"111","author":"Sarika","year":"2015","journal-title":"Comput. Electron. Agric."},{"key":"2023010804315992300_B26","doi-asserted-by":"crossref","first-page":"42362","DOI":"10.1038\/srep42362","article-title":"Predicting antimicrobial peptides with improved accuracy by incorporating the compositional, physico-chemical and structural features into chou's general PseAAC","volume":"7","author":"Meher","year":"2017","journal-title":"Sci. Rep."},{"key":"2023010804315992300_B27","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1021\/ci4007003","article-title":"Prediction of linear cationic antimicrobial peptides based on characteristics responsible for their interaction with the membranes","volume":"54","author":"Vishnepolsky","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"2023010804315992300_B28","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/psc.2532","article-title":"In vitro activity of novel in silico-developed antimicrobial peptides against a panel of bacterial pathogens","volume":"19","author":"Romani","year":"2013","journal-title":"J. Peptide Sci."},{"key":"2023010804315992300_B29","doi-asserted-by":"crossref","first-page":"212715","DOI":"10.1155\/2015\/212715","article-title":"Prediction of antimicrobial peptides based on sequence alignment and support vector machine-pairwise algorithm utilizing LZ-complexity","volume":"2015","author":"Ng","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"2023010804315992300_B30","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1093\/bioinformatics\/btt518","article-title":"CPPpred: prediction of cell penetrating peptides","volume":"29","author":"Holton","year":"2013","journal-title":"Bioinformatics"},{"key":"2023010804315992300_B31","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1038\/srep02984","article-title":"In silico models for designing and discovering novel anticancer peptides","volume":"3","author":"Tyagi","year":"2013","journal-title":"Sci. Rep."},{"key":"2023010804315992300_B32","doi-asserted-by":"crossref","first-page":"e0214001","DOI":"10.1371\/journal.pone.0214001","article-title":"The transcriptome analysis of protaetia brevitarsis lewis larvae","volume":"14","author":"Li","year":"2019","journal-title":"PLoS One"},{"key":"2023010804315992300_B33","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1007\/s00253-018-09593-y","article-title":"Discovery and identification of antimicrobial peptides in sichuan pepper (Zanthoxylum bungeanum maxim) seeds by peptidomics and bioinformatics","volume":"103","author":"Hou","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"2023010804315992300_B34","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00726-018-2575-x","article-title":"Prediction and characterization of a novel hemocyanin-derived antimicrobial peptide from shrimp litopenaeus vannamei","volume":"50","author":"Yang","year":"2018","journal-title":"Amino Acids"},{"key":"2023010804315992300_B35","doi-asserted-by":"crossref","first-page":"14531","DOI":"10.3390\/ijms150814531","article-title":"New milk protein-derived peptides with potential antimicrobial activity: an approach based on bioinformatic studies","volume":"15","author":"Dziuba","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"2023010804315992300_B36","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jprot.2017.01.005","article-title":"Proteomic and peptidomic analysis of human sweat with emphasis on proteolysis","volume":"155","author":"Yu","year":"2017","journal-title":"J. Proteomics"},{"key":"2023010804315992300_B37","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.3390\/ijms17081363","article-title":"Antimicrobial protein candidates from the thermophilic geobacillus sp. Strain ZGt-1: production, proteomics, and bioinformatics analysis","volume":"17","author":"Alkhalili","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"2023010804315992300_B38","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1021\/acs.jproteome.6b00857","article-title":"Discovery of novel antimicrobial peptides from varanus komodoensis (Komodo dragon) by large-scale analyses and de-novo-assisted sequencing using electron-transfer dissociation mass spectrometry","volume":"16","author":"Bishop","year":"2017","journal-title":"J. Proteome Res."},{"key":"2023010804315992300_B39","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1021\/acs.jproteome.5b00447","article-title":"Large scale discovery and de novo-assisted sequencing of cationic antimicrobial peptides (CAMPs) by microparticle capture and electron-transfer dissociation (ETD) mass spectrometry","volume":"14","author":"Juba","year":"2015","journal-title":"J. Proteome Res."},{"key":"2023010804315992300_B40","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1021\/acs.jproteome.5b00179","article-title":"Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification","volume":"14","author":"Azkargorta","year":"2015","journal-title":"J. Proteome Res."},{"key":"2023010804315992300_B41","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.4014\/jmb.1608.08029","article-title":"Transcriptome profiling and in silico analysis of the antimicrobial peptides of the grasshopper oxya chinensis sinuosa","volume":"26","author":"Kim","year":"2016","journal-title":"J. Microbiol. Biotechnol."},{"key":"2023010804315992300_B42","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1094\/PHYTO-09-13-0252-R","article-title":"A potent antimicrobial peptide derived from the protein lsgrp1 of lilium","volume":"104","author":"Lin","year":"2014","journal-title":"Phytopathology"},{"key":"2023010804315992300_B43","doi-asserted-by":"crossref","first-page":"e1005469","DOI":"10.1371\/journal.pgen.1005469","article-title":"Genome sequence and transcriptome analyses of chrysochromulina tobin: metabolic tools for enhanced algal fitness in the prominent order prymnesiales (Haptophyceae)","volume":"11","author":"Hovde","year":"2015","journal-title":"PLoS Genet."},{"key":"2023010804315992300_B44","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3390\/md15080261","article-title":"Myticalins: a novel multigenic family of linear, cationic antimicrobial peptides from marine mussels (Mytilus spp","volume":"15","author":"Leoni","year":"2017","journal-title":"Mar. Drugs"},{"key":"2023010804315992300_B45","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.bbagen.2018.06.011","article-title":"Joker: an algorithm to insert patterns into sequences for designing antimicrobial peptides","volume":"1862","author":"Porto","year":"2018","journal-title":"Biochim. Biophys. Acta. Gen. Subj."},{"key":"2023010804315992300_B46","doi-asserted-by":"crossref","first-page":"D20","DOI":"10.1093\/nar\/gkab1112","article-title":"Database resources of the national center for biotechnology information","volume":"50","author":"Sayers","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2023010804315992300_B47","doi-asserted-by":"crossref","first-page":"D437","DOI":"10.1093\/nar\/gkaa1038","article-title":"RCSB protein data bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences","volume":"49","author":"Burley","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2023010804315992300_B48","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/bioinformatics\/btq003","article-title":"CD-HIT suite: a web server for clustering and comparing biological sequences","volume":"26","author":"Huang","year":"2010","journal-title":"Bioinformatics"},{"key":"2023010804315992300_B49","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkaa1100","article-title":"UniProt: the universal protein knowledgebase in 2021","volume":"49","author":"UniProt Consortium","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2023010804315992300_B50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v011.i09","article-title":"kernlab - An S4 package for kernel methods in R","volume":"11","author":"Karatzoglou","year":"2004","journal-title":"J. Stat. Softw."},{"key":"2023010804315992300_B51","first-page":"18","article-title":"Classification and regression by random forest","volume":"2","author":"Liaw","year":"2002","journal-title":"R News"},{"key":"2023010804315992300_B52","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-21706-2","volume-title":"Modern Applied Statistics with S. Fourth Edition","author":"Venables","year":"2002"},{"key":"2023010804315992300_B53","doi-asserted-by":"crossref","first-page":"24684","DOI":"10.1038\/srep24684","article-title":"Leveraging family-specific signatures for AMP discovery and high-throughput annotation","volume":"6","author":"Waghu","year":"2016","journal-title":"Sci. Rep."},{"key":"2023010804315992300_B54","first-page":"227","article-title":"Multiple sequence alignment","volume":"227","author":"Sievers","year":"2020","journal-title":"Bioinformatics"},{"key":"2023010804315992300_B55","doi-asserted-by":"crossref","first-page":"e1002195","DOI":"10.1371\/journal.pcbi.1002195","article-title":"Accelerated profile HMM searches","volume":"7","author":"Eddy","year":"2011","journal-title":"PLoS Comput. Biol."},{"key":"2023010804315992300_B56","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/bip.20911","article-title":"Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides","volume":"90","author":"Jiang","year":"2008","journal-title":"Biopolymers"},{"key":"2023010804315992300_B57","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s13238-014-0061-0","article-title":"Role of helicity of \u03b1-helical antimicrobial peptides to improve specificity","volume":"5","author":"Huang","year":"2014","journal-title":"Protein Cell"},{"key":"2023010804315992300_B58","doi-asserted-by":"crossref","first-page":"D154","DOI":"10.1093\/nar\/gki070","article-title":"The universal protein resource (UniProt)","volume":"33","author":"Bairoch","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"2023010804315992300_B59","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/1471-2105-8-211","article-title":"Composition profiler: a tool for discovery and visualization of amino acid composition differences","volume":"8","author":"Vacic","year":"2007","journal-title":"BMC Bioinf."},{"key":"2023010804315992300_B60","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0022-2836(84)90309-7","article-title":"Analysis of membrane and surface protein sequences with the hydrophobic moment plot","volume":"179","author":"Eisenberg","year":"1984","journal-title":"J. Mol. Biol."},{"key":"2023010804315992300_B61","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0022-2836(73)90030-2","article-title":"Logical analysis of the mechanism of protein folding. I. Predictions of helices, loops and beta-structures from primary structure","volume":"75","author":"Nagano","year":"1973","journal-title":"J. Mol. Biol."},{"key":"2023010804315992300_B62","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S1093-3263(00)00138-8","article-title":"Intrinsically disordered protein","volume":"19","author":"Dunker","year":"2001","journal-title":"J. Mol. Graph. Model."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/51\/D1\/D377\/48441412\/gkac933.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/51\/D1\/D377\/48441412\/gkac933.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T23:35:41Z","timestamp":1673134541000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/51\/D1\/D377\/6825344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,12]]},"references-count":62,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2022,11,12]]},"published-print":{"date-parts":[[2023,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkac933","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,6]]},"published":{"date-parts":[[2022,11,12]]}}}