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Some major highlights include: the integration of Google Patents data into PubChem, which greatly expanded the coverage of the PubChem Patent data collection; the creation of the Cell Line and Taxonomy\u00a0data collections, which provide quick and easy access to chemical information for a given cell line and taxon, respectively; and the update of the\u00a0bioassay data model. In addition, new functionalities were added to the PubChem programmatic access protocols,\u00a0PUG-REST and PUG-View, including support for target-centric data download for a given protein, gene, pathway, cell line, and taxon and the addition of the \u2018standardize\u2019 option to PUG-REST, which returns the standardized form of an input chemical structure. A significant update was also made to PubChemRDF. 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