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As chromatin immunoprecipitation sequencing (ChIP-seq) data associated with CRs are rapidly accumulating, a comprehensive resource of CRs needs to be built urgently for collecting, integrating, and processing these data, which can provide abundant annotated information on CR upstream and downstream regulatory analyses as well as CR-related analysis functions. This study established an integrative CR resource, named CRdb (http:\/\/cr.liclab.net\/crdb\/), with the aim of curating a large number of available resources for CRs and providing extensive annotations and analyses of CRs to help biological researchers clarify the regulation mechanism and function of CRs. The CRdb database comprised a total of 647 CRs and 2,591 ChIP-seq samples from more than 300 human tissues and cell types. These samples have been manually curated from NCBI GEO\/SRA and ENCODE. Importantly, CRdb provided the abundant and detailed genetic annotations in CR-binding regions based on ChIP-seq. Furthermore, CRdb supported various functional annotations and upstream regulatory information on CRs. In particular, it embedded four types of CR regulatory analyses: CR gene set enrichment, CR-binding genomic region annotation, CR-TF co-occupancy analysis, and CR regulatory axis analysis. CRdb is a useful and powerful resource that can help in exploring the potential functions of CRs and their regulatory mechanism in diseases and biological processes.<\/jats:p>","DOI":"10.1093\/nar\/gkac960","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T15:48:22Z","timestamp":1667317702000},"page":"D88-D100","source":"Crossref","is-referenced-by-count":13,"title":["CRdb: a comprehensive resource for deciphering chromatin regulators in human"],"prefix":"10.1093","volume":"51","author":[{"given":"Yimeng","family":"Zhang","sequence":"first","affiliation":[{"name":"The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College , Shantou \u00a0515041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuexin","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China"},{"name":"School of Computer, University of South China , Hengyang , Hunan \u00a0421001, China"},{"name":"The First Affiliated Hospital, Cardiovascular Lab of Big Data and Imaging Artificial Intelligence, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China"},{"name":"Hunan Provincial Base for Scientific and Technological Innovation Cooperation, University of South China , Hengyang , Hunan \u00a0421001, China"},{"name":"The First Affiliated Hospital, Department of Cardiology, Hengyang Medical School, University of South China ,\u00a0 Hengyang ,\u00a0 Hunan \u00a0421001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Song","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China"},{"name":"School of Computer, University of South China , Hengyang , Hunan \u00a0421001, China"},{"name":"The First Affiliated Hospital, Cardiovascular Lab of Big Data and Imaging Artificial Intelligence, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China"},{"name":"Hunan Provincial Base for Scientific and Technological Innovation Cooperation, University of South China , Hengyang , Hunan \u00a0421001, China"},{"name":"The First Affiliated Hospital, Department of Cardiology, Hengyang Medical School, University of South China ,\u00a0 Hengyang ,\u00a0 Hunan \u00a0421001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xilong","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing \u00a0163319, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Ai","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing \u00a0163319, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuezhu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing \u00a0163319, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing \u00a0163319, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing \u00a0163319, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenchen","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing \u00a0163319, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1618-4292","authenticated-orcid":false,"given":"Liyan","family":"Xu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College , Shantou \u00a0515041, China"},{"name":"Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Institute of Oncologic Pathology, Cancer Research Center, Shantou University Medical College , Shantou \u00a0515041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyu","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China"},{"name":"School of Computer, University of South China , Hengyang , Hunan \u00a0421001, China"},{"name":"The First Affiliated Hospital, Cardiovascular Lab of Big Data and Imaging Artificial Intelligence, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China"},{"name":"Hunan Provincial Base for Scientific and Technological Innovation Cooperation, University of South China , Hengyang , Hunan \u00a0421001, China"},{"name":"The First Affiliated Hospital, Department of Cardiology, Hengyang Medical School, University of South China ,\u00a0 Hengyang ,\u00a0 Hunan \u00a0421001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Sun","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College , Shantou \u00a0515041, China"},{"name":"Department of Biochemistry and Molecular Biology, Shantou University Medical College , Shantou \u00a0515041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoli","family":"Fang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China"},{"name":"School of Computer, University of South China , Hengyang , Hunan \u00a0421001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozheng","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University. 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