{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:42:50Z","timestamp":1772768570959,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFA0903700"],"award-info":[{"award-number":["2018YFA0903700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21621004"],"award-info":[{"award-number":["21621004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31801104"],"award-info":[{"award-number":["31801104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>DoriC was first launched in 2007 as a database of replication origins (oriCs) in bacterial genomes and has since been constantly updated to integrate the latest research progress in this field. The database was subsequently extended to include the oriCs in archaeal genomes as well as those in plasmids. This latest release, DoriC 12.0, includes the oriCs in both draft and complete prokaryotic genomes. At the same time, the number of oriCs in the database has also increased significantly and currently contains over 200 000 bacterial entries distributed in more than 40 phyla. Among them, a large number are from bacteria in new phyla whose oriCs were not explored before. Additionally, new oriC features and improvements have been introduced, especially in the visualization and analysis of oriCs. Currently, DoriC is considered as an important database in the fields of bioinformatics, microbial genomics, and even synthetic biology, providing a valuable resource as well as a comprehensive platform for the research on oriCs. DoriC 12.0 can be accessed at https:\/\/tubic.org\/doric\/ and http:\/\/tubic.tju.edu.cn\/doric\/.<\/jats:p>","DOI":"10.1093\/nar\/gkac964","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T15:40:26Z","timestamp":1666971626000},"page":"D117-D120","source":"Crossref","is-referenced-by-count":42,"title":["DoriC 12.0: an updated database of replication origins in both complete and draft prokaryotic genomes"],"prefix":"10.1093","volume":"51","author":[{"given":"Mei-Jing","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Physics, School of Science, Tianjin University , Tianjin \u00a0300072, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2714-8817","authenticated-orcid":false,"given":"Hao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Physics, School of Science, Tianjin University , Tianjin \u00a0300072, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9563-3841","authenticated-orcid":false,"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Physics, School of Science, Tianjin University , Tianjin \u00a0300072, China"},{"name":"Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University , Tianjin \u00a0300072, China"},{"name":"SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin \u00a0300072, China"}]}],"member":"286","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"2023010804250240100_B1","doi-asserted-by":"crossref","first-page":"e1002549","DOI":"10.1371\/journal.pgen.1002549","article-title":"Cell size and the initiation of DNA replication in bacteria","volume":"8","author":"Hill","year":"2012","journal-title":"PLoS Genet."},{"key":"2023010804250240100_B2","first-page":"735","article-title":"oriC-encoded instructions for the initiation of bacterial chromosome replication","volume":"5","author":"Wolanski","year":"2015","journal-title":"Front. 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