{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:22:16Z","timestamp":1777411336095,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U41HG009889"],"award-info":[{"award-number":["U41HG009889"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>RNA binding proteins (RBPs) are central regulators of gene expression implicated in all facets of RNA metabolism. As such, they play key roles in cellular physiology and disease etiology. Since different steps of post-transcriptional gene expression tend to occur in specific regions of the cell, including nuclear or cytoplasmic locations, defining\u00a0the subcellular distribution properties of RBPs is an important step in assessing their potential functions. Here, we present the RBP Image Database, a resource that details the subcellular localization features of 301 RBPs in the human HepG2 and HeLa cell lines, based on the results of systematic immuno-fluorescence studies conducted using a highly validated collection of RBP antibodies and a panel of 12 markers for specific organelles and subcellular structures. The unique features of the RBP Image Database include: (i) hosting of comprehensive representative images for each RBP-marker pair, with \u223c250,000 microscopy images; (ii) a manually curated controlled vocabulary of annotation terms detailing the localization features of each factor; and (iii) a user-friendly interface allowing the rapid querying of the data by target or annotation. The RBP Image Database is freely available at https:\/\/rnabiology.ircm.qc.ca\/RBPImage\/.<\/jats:p>","DOI":"10.1093\/nar\/gkac971","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T22:23:27Z","timestamp":1667255007000},"page":"D1549-D1557","source":"Crossref","is-referenced-by-count":10,"title":["RBP Image Database: A resource for the systematic characterization of the subcellular distribution properties of human RNA binding proteins"],"prefix":"10.1093","volume":"51","author":[{"given":"Louis Philip","family":"Benoit\u00a0Bouvrette","sequence":"first","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al (IRCM) Montr\u00e9al , Qu\u00e9bec , Canada"},{"name":"D\u00e9partement de Biochimie et M\u00e9decine Mol\u00e9culaire, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al , Qu\u00e9bec , Canada"}]},{"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al (IRCM) Montr\u00e9al , Qu\u00e9bec , Canada"}]},{"given":"Jonathan","family":"Boulais","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al (IRCM) Montr\u00e9al , Qu\u00e9bec , Canada"}]},{"given":"Jian","family":"Kong","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al (IRCM) Montr\u00e9al , Qu\u00e9bec , Canada"}]},{"given":"Easin\u00a0Uddin","family":"Syed","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al (IRCM) Montr\u00e9al , Qu\u00e9bec , Canada"},{"name":"D\u00e9partement de Biochimie et M\u00e9decine Mol\u00e9culaire, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al , Qu\u00e9bec , Canada"}]},{"given":"Steven\u00a0M","family":"Blue","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California , San Diego, La Jolla , CA , USA"}]},{"given":"Lijun","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genome Sciences, UConn Health Center , Farmington , CT , USA"}]},{"given":"Sara","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genome Sciences, UConn Health Center , Farmington , CT , USA"}]},{"given":"Rebecca","family":"Stanton","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California , San Diego, La Jolla , CA , USA"}]},{"given":"Xintao","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genome Sciences, UConn Health Center , Farmington , CT , USA"}]},{"given":"Brian","family":"Yee","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California , San Diego, La Jolla , CA , USA"}]},{"given":"Eric L","family":"Van\u00a0Nostrand","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California , San Diego, La Jolla , CA , USA"},{"name":"Verna & Marrs McLean Department of Biochemistry & Molecular Biology and Therapeutic Innovation Center, Baylor College of Medicine , Houston , TX , USA"}]},{"given":"Xiang-Dong","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California , San Diego, La Jolla , CA , USA"}]},{"given":"Christopher B","family":"Burge","sequence":"additional","affiliation":[{"name":"Program of Computational and Systems Biology, Department of Biology, MIT , Cambridge , MA , USA"}]},{"given":"Brenton\u00a0R","family":"Graveley","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genome Sciences, UConn Health Center , Farmington , CT , USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0799-6037","authenticated-orcid":false,"given":"Gene\u00a0W","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California , San Diego, La Jolla , CA , USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4383-342X","authenticated-orcid":false,"given":"Eric","family":"L\u00e9cuyer","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al (IRCM) Montr\u00e9al , Qu\u00e9bec , Canada"},{"name":"D\u00e9partement de Biochimie et M\u00e9decine Mol\u00e9culaire, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al , Qu\u00e9bec , Canada"},{"name":"Division of Experimental Medicine, McGill University , Montr\u00e9al, Qu\u00e9bec, Canada"}]}],"member":"286","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"2023010804314597000_B1","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1093\/nar\/30.7.1427","article-title":"Comparative genomics and evolution of proteins involved in RNA metabolism","volume":"30","author":"Anantharaman","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"2023010804314597000_B2","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nrg3813","article-title":"A census of human RNA-binding proteins","volume":"15","author":"Gerstberger","year":"2014","journal-title":"Nat. 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Natl. Acad. Sci. U. S. A."},{"key":"2023010804314597000_B30","doi-asserted-by":"crossref","first-page":"eaal3321","DOI":"10.1126\/science.aal3321","article-title":"A subcellular map of the human proteome","volume":"356","author":"Thul","year":"2017","journal-title":"Science"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/51\/D1\/D1549\/48441382\/gkac971.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/51\/D1\/D1549\/48441382\/gkac971.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T04:35:26Z","timestamp":1673152526000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/51\/D1\/D1549\/6793800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":30,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2022,11,2]]},"published-print":{"date-parts":[[2023,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkac971","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,6]]},"published":{"date-parts":[[2022,11,2]]}}}