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Whilst the number of single-cell sequencing studies is increasing dramatically; however, data mining and reanalysis remains challenging. Herein, we systematically curated the up-to-date and most comprehensive datasets of sequencing data originating from 2760 bulk samples and over 5.1 million single-cells from multiple developmental periods from humans and multiple model organisms. With unified and systematic analysis, we profiled the gene expression and chromatin accessibility among 481 cell-types, 79 tissue-types and 92 timepoints, and pinpointed cells with the co-expression of target genes. We also enabled the detection of gene(s) with a temporal and cell-type specific expression profile that is similar to or distinct from that of a target gene. Additionally, we illustrated the potential upstream and downstream gene\u2212gene regulation interactions, particularly under the same biological process(es) or KEGG pathway(s). Thus, TEDD (Temporal Expression during Development Database), a value-added database with a user-friendly interface, not only enables researchers to identify cell-type\/tissue-type specific and temporal gene expression and chromatin profiles but also facilitates the association of genes with undefined biological functions in development and diseases. The database URL is https:\/\/TEDD.obg.cuhk.edu.hk\/.<\/jats:p>","DOI":"10.1093\/nar\/gkac978","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T16:39:16Z","timestamp":1668011956000},"page":"D1168-D1178","source":"Crossref","is-referenced-by-count":24,"title":["TEDD: a database of temporal gene expression patterns during multiple developmental periods in human and model organisms"],"prefix":"10.1093","volume":"51","author":[{"given":"Ziheng","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong , Hong Kong , China"},{"name":"Shenzhen Research Institute, The Chinese University of Hong Kong , Shenzhen 518057 , China"},{"name":"Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong , Hong Kong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Genomics, BGI-Shenzhen , Shenzhen , 518083 , China"},{"name":"BGI-Shenzhen , Shenzhen 518083 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew\u00a0Hoi\u00a0Kin","family":"Chau","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong , Hong Kong , China"},{"name":"Shenzhen Research Institute, The Chinese University of Hong Kong , Shenzhen 518057 , China"},{"name":"Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong , Hong Kong , China"},{"name":"The Chinese University of Hong Kong-Baylor College of Medicine Joint Center for Medical Genetics , Hong Kong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaosen","family":"Jiang","sequence":"additional","affiliation":[{"name":"BGI-Shenzhen , Shenzhen 518083 , China"},{"name":"College of Life Sciences, University of Chinese Academy of Sciences , Beijing 100049 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyuan","family":"Ke","sequence":"additional","affiliation":[{"name":"BGI-Shenzhen , Shenzhen 518083 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0554-2031","authenticated-orcid":false,"given":"Xiaoyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong , Hong Kong , China"},{"name":"Maternal-Fetal Medicine Institute, Shenzhen Baoan Women's and Children's Hospital, Shenzhen University , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong , Hong Kong , China"},{"name":"Shenzhen Research Institute, The Chinese University of Hong Kong , Shenzhen 518057 , China"},{"name":"Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong , Hong Kong , China"},{"name":"The Fertility Preservation Research Center, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong , Hong Kong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne K","family":"Kwok","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong , Hong Kong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Bellgard","sequence":"additional","affiliation":[{"name":"eResearch Office, Queensland University of Technology , Brisbane , QLD , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tak\u00a0Yeung","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong , Hong Kong , China"},{"name":"Shenzhen Research Institute, The Chinese University of Hong Kong , Shenzhen 518057 , China"},{"name":"Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong , Hong Kong , China"},{"name":"The Chinese University of Hong Kong-Baylor College of Medicine Joint Center for Medical Genetics , Hong Kong , China"},{"name":"The Fertility Preservation Research Center, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong , Hong Kong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3616-6200","authenticated-orcid":false,"given":"Kwong\u00a0Wai","family":"Choy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong , Hong Kong , China"},{"name":"Shenzhen Research Institute, The Chinese University of Hong Kong , Shenzhen 518057 , China"},{"name":"Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong , Hong Kong , China"},{"name":"The Chinese University of Hong 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