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LncTarD 2.0 is freely available at (http:\/\/bio-bigdata.hrbmu.edu.cn\/LncTarD or https:\/\/lnctard.bio-database.com\/). LncTarD 2.0 was updated with several new features, including (i) an increased number of disease-associated lncRNA entries, where the current release provides 8360 key lncRNA\u2013target regulations, with 419 disease subtypes and 1355 lncRNAs; (ii) predicted 3312 out of 8360 lncRNA\u2013target regulations as potential diagnostic or therapeutic biomarkers in circulating tumor cells (CTCs); (iii) addition of 536 new, experimentally supported lncRNA\u2013target regulations that modulate properties of cancer stem cells; (iv) addition of an experimentally supported clinical application section of 2894 lncRNA\u2013target regulations for potential clinical application. Importantly, LncTarD 2.0 provides RNA-seq\/microarray and single-cell web tools for customizable analysis and visualization of lncRNA\u2013target regulations in diseases. RNA-seq\/microarray web tool was used to mining lncRNA\u2013target regulations in both disease tissue samples and CTCs blood samples. The single-cell web tools provide single-cell lncRNA\u2013target annotation from the perspectives of pan-cancer analysis and cancer-specific analysis at the single-cell level. LncTarD 2.0 will be a useful resource and mining tool for the investigation of the functions and mechanisms of lncRNA deregulation in human disease.<\/jats:p>","DOI":"10.1093\/nar\/gkac984","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T21:36:30Z","timestamp":1667252190000},"page":"D199-D207","source":"Crossref","is-referenced-by-count":68,"title":["LncTarD 2.0: an updated comprehensive database for experimentally-supported functional lncRNA\u2013target regulations in human diseases"],"prefix":"10.1093","volume":"51","author":[{"given":"Hongying","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , China"}]},{"given":"Xiangzhe","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , China"}]},{"given":"Haotian","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , China"}]},{"given":"Kailai","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , China"}]},{"given":"Wangyang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , China"}]},{"given":"Lixia","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , China"}]},{"given":"Caiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , China"}]},{"given":"Lin","family":"Bo","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , China"}]},{"given":"Xicheng","family":"Lan","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , China"}]},{"given":"Shihua","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , China"}]},{"given":"Ke","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4079-8945","authenticated-orcid":false,"given":"Shangwei","family":"Ning","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , China"}]},{"given":"Yunpeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1936-8513","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin 150081 , China"}]}],"member":"286","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"2023010804240822800_B1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.arr.2019.04.001","article-title":"LncRNA: shedding light on mechanisms and opportunities in fibrosis and aging","volume":"52","author":"Yang","year":"2019","journal-title":"Ageing Res. 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