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An updated version of the EpiFactors contains information on 902 proteins, including 101 histones and protamines, and, as a main update, a newly curated collection of 124 lncRNAs involved in epigenetic regulation. The amount of publications concerning the role of lncRNA in epigenetics is rapidly growing. Yet, the resource that compiles, integrates, organizes, and presents curated information on lncRNAs in epigenetics is missing. EpiFactors fills this gap and provides data on epigenetic regulators in an accessible and user-friendly form. For 820 of the genes in EpiFactors, we include expression estimates across multiple cell types assessed by CAGE-Seq in the FANTOM5 project. In addition, the updated EpiFactors contains information on 73 protein complexes involved in epigenetic regulation. Our resource is practical for a wide range of users, including biologists, bioinformaticians and molecular\/systems biologists.<\/jats:p>","DOI":"10.1093\/nar\/gkac989","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T16:40:16Z","timestamp":1668012016000},"page":"D564-D570","source":"Crossref","is-referenced-by-count":76,"title":["EpiFactors 2022: expansion and enhancement of a curated database of human epigenetic factors and complexes"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6928-2438","authenticated-orcid":false,"given":"Daria","family":"Marakulina","sequence":"first","affiliation":[{"name":"Department of Biological and Medical Physics, Moscow Institute of Physics and Technology , 141701, Dolgoprudny, Moscow Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya E","family":"Vorontsov","sequence":"additional","affiliation":[{"name":"Vavilov Institute of General Genetics, Russian Academy of Sciences , 119991\u00a0Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6554-8128","authenticated-orcid":false,"given":"Ivan V","family":"Kulakovskiy","sequence":"additional","affiliation":[{"name":"Vavilov Institute of General Genetics, Russian Academy of Sciences , 119991\u00a0Moscow, Russia"},{"name":"Institute of Protein Research, Russian Academy of Sciences , Pushchino\u00a0142290, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Lennartsson","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Nutrition, NEO, Karolinska Institutet , 14157, Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Drabl\u00f8s","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology , PO\u00a0Box 8905, NO-7491 Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7587-1666","authenticated-orcid":false,"given":"Yulia\u00a0A","family":"Medvedeva","sequence":"additional","affiliation":[{"name":"Department of Biological and Medical Physics, Moscow Institute of Physics and Technology , 141701, Dolgoprudny, Moscow Region, Russia"},{"name":"Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Science , 117312\u00a0Moscow, Russia"},{"name":"The National Medical Research Center for Endocrinology , 117036\u00a0Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"2023010804235809200_B1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41586-019-1411-0","article-title":"Advances in epigenetics link genetics to the environment and disease","volume":"571","author":"Cavalli","year":"2019","journal-title":"Nature"},{"key":"2023010804235809200_B2","first-page":"630","article-title":"FGD5-AS1 is a Hub lncRNA ceRNA in hearts with tetralogy of fallot which regulates congenital heart disease genes transcriptionally and epigenetically","volume":"9","author":"Zhang","year":"2021","journal-title":"Front. 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