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Here, we present LncBook 2.0 (https:\/\/ngdc.cncb.ac.cn\/lncbook), with significant updates and enhancements as follows: (i) incorporation of 119 722 new transcripts, 9632 new genes, and gene structure update of 21 305 lncRNAs; (ii) characterization of conservation features of human lncRNA genes across 40 vertebrates; (iii) integration of lncRNA-encoded small proteins; (iv) enrichment of expression and DNA methylation profiles with more biological contexts\u00a0and (v) identification of lncRNA\u2013protein interactions and improved prediction of lncRNA-miRNA interactions. Collectively, LncBook 2.0 accommodates a high-quality collection of 95 243 lncRNA genes and 323 950 transcripts and incorporates their abundant annotations at different omics levels, thereby enabling users to decipher functional significance of lncRNAs in different biological contexts.<\/jats:p>","DOI":"10.1093\/nar\/gkac999","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T10:00:33Z","timestamp":1667556033000},"page":"D186-D191","source":"Crossref","is-referenced-by-count":83,"title":["LncBook 2.0: integrating human long non-coding RNAs with multi-omics annotations"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7374-3348","authenticated-orcid":false,"given":"Zhao","family":"Li","sequence":"first","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101 , China"},{"name":"China National Center for Bioinformation , Beijing 100101 , China"},{"name":"University of Chinese Academy of Sciences , Beijing 100049 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0419-6130","authenticated-orcid":false,"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101 , China"},{"name":"China National Center for Bioinformation , Beijing 100101 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2024-8575","authenticated-orcid":false,"given":"Changrui","family":"Feng","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101 , China"},{"name":"China National Center for Bioinformation , Beijing 100101 , China"},{"name":"University of Chinese Academy of Sciences , Beijing 100049 , China"}]},{"given":"Yuxin","family":"Qin","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101 , China"},{"name":"China National Center for Bioinformation , Beijing 100101 , China"},{"name":"University of Chinese Academy of Sciences , Beijing 100049 , China"}]},{"given":"Jingfa","family":"Xiao","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101 , China"},{"name":"China National Center for Bioinformation , Beijing 100101 , China"},{"name":"University of Chinese Academy of Sciences , Beijing 100049 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6603-5060","authenticated-orcid":false,"given":"Zhang","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101 , China"},{"name":"China National Center for Bioinformation , Beijing 100101 , China"},{"name":"University of Chinese Academy of Sciences , Beijing 100049 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6390-6289","authenticated-orcid":false,"given":"Lina","family":"Ma","sequence":"additional","affiliation":[{"name":"National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101 , China"},{"name":"China National Center for Bioinformation , Beijing 100101 , China"},{"name":"University of Chinese Academy of Sciences , Beijing 100049 , China"}]}],"member":"286","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"2023010804294527100_B1","doi-asserted-by":"crossref","first-page":"D128","DOI":"10.1093\/nar\/gky960","article-title":"LncBook: a curated knowledgebase of human long non-coding RNAs","volume":"47","author":"Ma","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2023010804294527100_B2","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1093\/bioinformatics\/btab127","article-title":"lncLocator 2.0: a cell-line-specific subcellular localization predictor for long non-coding RNAs with interpretable deep learning","volume":"37","author":"Lin","year":"2021","journal-title":"Bioinformatics"},{"key":"2023010804294527100_B3","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s40291-019-00427-9","article-title":"The long non-coding RNA landscape of atherosclerotic plaques","volume":"23","author":"Kraczkowska","year":"2019","journal-title":"Mol. 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