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Such interactions occur with specific small molecules due to geometric and physicochemical complementarity with the receptor. In this scenario, we present KVFinder-web, an open-source web-based application of parKVFinder software for cavity detection and characterization of biomolecular structures. The KVFinder-web has two independent components: a RESTful web service and a web graphical portal. Our web service, KVFinder-web service, handles client requests, manages accepted jobs, and performs cavity detection and characterization on accepted jobs. Our graphical web portal, KVFinder-web portal, provides a simple and straightforward page for cavity analysis, which customizes detection parameters, submits jobs to the web service component, and displays cavities and characterizations. We provide a publicly available KVFinder-web at https:\/\/kvfinder-web.cnpem.br, running in a cloud environment as docker containers. Further, this deployment type allows KVFinder-web components to be configured locally and customized according to user demand. Hence, users may run jobs on a locally configured service or our public KVFinder-web.<\/jats:p>","DOI":"10.1093\/nar\/gkad324","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T12:26:20Z","timestamp":1683203180000},"page":"W289-W297","source":"Crossref","is-referenced-by-count":42,"title":["KVFinder-web: a web-based application for detecting and characterizing biomolecular cavities"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6800-4425","authenticated-orcid":false,"given":"Jo\u00e3o V S","family":"Guerra","sequence":"first","affiliation":[{"name":"Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM) , Campinas, S\u00e3o Paulo, \u00a013083-100, Brazil"},{"name":"Graduate Program in Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, University of Campinas , Campinas, S\u00e3o Paulo , 13083-871, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helder V","family":"Ribeiro-Filho","sequence":"additional","affiliation":[{"name":"Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM) , Campinas, S\u00e3o Paulo, \u00a013083-100, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 G C","family":"Pereira","sequence":"additional","affiliation":[{"name":"Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM) , Campinas, S\u00e3o Paulo, \u00a013083-100, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1287-8019","authenticated-orcid":false,"given":"Paulo\u00a0S","family":"Lopes-de-Oliveira","sequence":"additional","affiliation":[{"name":"Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM) , Campinas, S\u00e3o Paulo, \u00a013083-100, Brazil"},{"name":"Graduate Program in Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, University of Campinas , Campinas, S\u00e3o Paulo , 13083-871, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"2023070504592014400_B1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/cgf.13158","article-title":"Geometric detection algorithms for cavities on protein surfaces in molecular graphics: a survey","volume":"36","author":"Sim\u00f5es","year":"2017","journal-title":"Comput. 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