{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T02:24:54Z","timestamp":1782181494144,"version":"3.54.5"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF20CC0035580"],"award-info":[{"award-number":["NNF20CC0035580"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF16OC0021746"],"award-info":[{"award-number":["NNF16OC0021746"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"publisher","award":["DNRF137"],"award-info":[{"award-number":["DNRF137"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ERC Starting Grant","award":["948770-DECIPHER"],"award-info":[{"award-number":["948770-DECIPHER"]}]},{"name":"Novel Antibacterial Compounds and Therapies Antagonising Resistance program"},{"DOI":"10.13039\/501100003246","name":"Dutch Research Council","doi-asserted-by":"publisher","award":["16440"],"award-info":[{"award-number":["16440"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Microorganisms produce small bioactive compounds as part of their secondary or specialised metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal, antiviral or other bio-activities and thus play an important role for applications in medicine and agriculture. In the past decade, genome mining has become a widely-used method to explore, access, and analyse the available biodiversity of these compounds. Since 2011, the \u2018antibiotics and secondary metabolite analysis shell\u2014antiSMASH\u2019 (https:\/\/antismash.secondarymetabolites.org\/) has supported researchers in their microbial genome mining tasks, both as a free to use web server and as a standalone tool under an OSI-approved open source licence. It is currently the most widely used tool for detecting and characterising biosynthetic gene clusters (BGCs) in archaea, bacteria, and fungi. Here, we present the updated version 7 of antiSMASH. antiSMASH 7 increases the number of supported cluster types from 71 to 81, as well as containing improvements in the areas of chemical structure prediction, enzymatic assembly-line visualisation and gene cluster regulation.<\/jats:p>","DOI":"10.1093\/nar\/gkad344","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T12:25:01Z","timestamp":1683203101000},"page":"W46-W50","source":"Crossref","is-referenced-by-count":2185,"title":["antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures\u00a0and visualisation"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3764-6051","authenticated-orcid":false,"given":"Kai","family":"Blin","sequence":"first","affiliation":[{"name":"The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , Kgs.Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Shaw","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , Kgs.Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1862-6699","authenticated-orcid":false,"given":"Hannah E","family":"Augustijn","sequence":"additional","affiliation":[{"name":"Molecular Biotechnology, Institute of Biology, Leiden University , Leiden , The Netherlands"},{"name":"Bioinformatics Group, Wageningen University , Wageningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1964-8221","authenticated-orcid":false,"given":"Zachary L","family":"Reitz","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Wageningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Biermann","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Wageningen , The Netherlands"},{"name":"Institute of Molecular Bio Science, Goethe-University Frankfurt , Frankfurt am Main , Germany"},{"name":"LOEWE Center for Translational Biodiversity Genomics. Frankfurt am Main , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8420-1325","authenticated-orcid":false,"given":"Mohammad","family":"Alanjary","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Wageningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artem","family":"Fetter","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Wageningen , The Netherlands"},{"name":"Institute of Technical Chemistry, Leibniz University Hannover , Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara R","family":"Terlouw","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Wageningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0182-0671","authenticated-orcid":false,"given":"William W","family":"Metcalf","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Illinois Urbana\u2013Champaign , Urbana , IL , USA"},{"name":"Institute for Genomic Biology, University of Illinois Urbana\u2013Champaign , Urbana , IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J N","family":"Helfrich","sequence":"additional","affiliation":[{"name":"Institute of Molecular Bio Science, Goethe-University Frankfurt , Frankfurt am Main , Germany"},{"name":"LOEWE Center for Translational Biodiversity Genomics. Frankfurt am Main , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0341-1561","authenticated-orcid":false,"given":"Gilles P","family":"van\u00a0Wezel","sequence":"additional","affiliation":[{"name":"Molecular Biotechnology, Institute of Biology, Leiden University , Leiden , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marnix H","family":"Medema","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Wageningen University , Wageningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-5120","authenticated-orcid":false,"given":"Tilmann","family":"Weber","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , Kgs.Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"2023070505003391300_B1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"2023070505003391300_B2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/ps.6653","article-title":"Impact of natural products on discovery of, and innovation in, crop protection compounds","volume":"78","author":"Sparks","year":"2022","journal-title":"Pest Manag. Sci."},{"key":"2023070505003391300_B3","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1039\/C6NP00025H","article-title":"The evolution of genome mining in microbes \u2013 a review","volume":"33","author":"Ziemert","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"2023070505003391300_B4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ijmm.2014.02.001","article-title":"In silico tools for the analysis of antibiotic biosynthetic pathways","volume":"304","author":"Weber","year":"2014","journal-title":"Int. J. Med. Microbiol."},{"key":"2023070505003391300_B5","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nchembio.1884","article-title":"Computational approaches to natural product discovery","volume":"11","author":"Medema","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"2023070505003391300_B6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.synbio.2015.12.002","article-title":"The secondary metabolite bioinformatics portal: computational tools to facilitate synthetic biology of secondary metabolite production","volume":"1","author":"Weber","year":"2016","journal-title":"Synth. Syst. Biotechnol."},{"key":"2023070505003391300_B7","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1093\/bib\/bbx146","article-title":"Recent development of antiSMASH and other computational approaches to mine secondary metabolite biosynthetic gene clusters","volume":"20","author":"Blin","year":"2019","journal-title":"Brief. Bioinform."},{"key":"2023070505003391300_B8","doi-asserted-by":"crossref","first-page":"W339","DOI":"10.1093\/nar\/gkr466","article-title":"antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences","volume":"39","author":"Medema","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"2023070505003391300_B9","doi-asserted-by":"crossref","first-page":"W204","DOI":"10.1093\/nar\/gkt449","article-title":"antiSMASH 2.0\u2014A versatile platform for genome mining of secondary metabolite producers","volume":"41","author":"Blin","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2023070505003391300_B10","doi-asserted-by":"crossref","first-page":"W237","DOI":"10.1093\/nar\/gkv437","article-title":"antiSMASH 3.0\u2014a comprehensive resource for the genome mining of biosynthetic gene clusters","volume":"43","author":"Weber","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2023070505003391300_B11","doi-asserted-by":"crossref","first-page":"W36","DOI":"10.1093\/nar\/gkx319","article-title":"antiSMASH 4.0\u2014Improvements in chemistry prediction and gene cluster boundary identification","volume":"45","author":"Blin","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2023070505003391300_B12","doi-asserted-by":"crossref","first-page":"W81","DOI":"10.1093\/nar\/gkz310","article-title":"antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline","volume":"47","author":"Blin","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2023070505003391300_B13","doi-asserted-by":"crossref","first-page":"W29","DOI":"10.1093\/nar\/gkab335","article-title":"antiSMASH 6.0: improving cluster detection and comparison capabilities","volume":"49","author":"Blin","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2023070505003391300_B14","doi-asserted-by":"crossref","first-page":"W546","DOI":"10.1093\/nar\/gkaa374","article-title":"ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining","volume":"48","author":"Mungan","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2023070505003391300_B15","doi-asserted-by":"crossref","first-page":"e1003822","DOI":"10.1371\/journal.pcbi.1003822","article-title":"Pep2Path: automated mass spectrometry-guided genome mining of peptidic natural products","volume":"10","author":"Medema","year":"2014","journal-title":"PLoS Comput. 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