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However, for biologists, the requirement of coding skills poses a significant obstacle to using FBA for pathway analysis and engineering target identification. Additionally, a time-consuming manual drawing process is often needed to illustrate the mass flow in an FBA-calculated pathway, making it challenging to detect errors or discover interesting metabolic features. To solve this problem, we developed CAVE, a cloud-based platform for the integrated calculation, visualization, examination and correction of metabolic pathways. CAVE can analyze and visualize pathways for over 100 published GEMs or user-uploaded GEMs, allowing for quicker examination and identification of special metabolic features in a particular GEM. Additionally, CAVE offers model modification functions, such as gene\/reaction removal or addition, making it easy for users to correct errors found in pathway analysis and obtain more reliable pathways. With a focus on the design and analysis of optimal pathways for biochemicals, CAVE complements existing visualization tools based on manually drawn global maps and can be applied to a broader range of organisms for rational metabolic engineering. CAVE is available at https:\/\/cave.biodesign.ac.cn\/.<\/jats:p>","DOI":"10.1093\/nar\/gkad360","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T19:42:15Z","timestamp":1683747735000},"page":"W70-W77","source":"Crossref","is-referenced-by-count":39,"title":["CAVE: a cloud-based platform for analysis and visualization of metabolic pathways"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-2585","authenticated-orcid":false,"given":"Zhitao","family":"Mao","sequence":"first","affiliation":[{"name":"Biodesign Center, Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences , Tianjin \u00a0300308, China"},{"name":"National Center of Technology Innovation for Synthetic Biology,\u00a0 Tianjin \u00a0300308, 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