{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:39:44Z","timestamp":1775266784603,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T00:00:00Z","timestamp":1683936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005690","name":"Saarland University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation","doi-asserted-by":"publisher","award":["14446"],"award-info":[{"award-number":["14446"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. 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To address this challenge, we developed miEAA, a flexible and comprehensive miRNA enrichment analysis tool based on direct and indirect miRNA annotation. The latest release of miEAA includes a data warehouse of 19 miRNA repositories, covering 10 different organisms and 139 399 functional categories. We have added information on the cellular context of miRNAs, isomiRs, and high-confidence miRNAs to improve the accuracy of the results. We have also improved the representation of aggregated results, including interactive Upset plots to aid users in understanding the interaction among enriched terms or categories. Finally, we demonstrate the functionality of miEAA in the context of ageing and highlight the importance of carefully considering the miRNA input list. MiEAA is free to use and publicly available at https:\/\/www.ccb.uni-saarland.de\/mieaa\/.<\/jats:p>","DOI":"10.1093\/nar\/gkad392","type":"journal-article","created":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T10:26:19Z","timestamp":1683973579000},"page":"W319-W325","source":"Crossref","is-referenced-by-count":97,"title":["miEAA 2023: updates, new functional microRNA sets and improved enrichment visualizations"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3470-1425","authenticated-orcid":false,"given":"Ernesto","family":"Aparicio-Puerta","sequence":"first","affiliation":[{"name":"Clinical Bioinformatics, Saarland University , 66123\u00a0 Saarbr\u00fccken , Germany"}]},{"given":"Pascal","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Clinical Bioinformatics, Saarland University , 66123\u00a0 Saarbr\u00fccken , Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9627-9223","authenticated-orcid":false,"given":"Georges P","family":"Schmartz","sequence":"additional","affiliation":[{"name":"Clinical Bioinformatics, Saarland University , 66123\u00a0 Saarbr\u00fccken , Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8223-3750","authenticated-orcid":false,"given":"Fabian","family":"Kern","sequence":"additional","affiliation":[{"name":"Clinical Bioinformatics, Saarland University , 66123\u00a0 Saarbr\u00fccken , Germany"},{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University Campus , 66123\u00a0 Saarbr\u00fccken , Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1967-2918","authenticated-orcid":false,"given":"Tobias","family":"Fehlmann","sequence":"additional","affiliation":[{"name":"Clinical Bioinformatics, Saarland University , 66123\u00a0 Saarbr\u00fccken , Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5361-0895","authenticated-orcid":false,"given":"Andreas","family":"Keller","sequence":"additional","affiliation":[{"name":"Clinical Bioinformatics, Saarland University , 66123\u00a0 Saarbr\u00fccken , Germany"},{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University Campus , 66123\u00a0 Saarbr\u00fccken , Germany"}]}],"member":"286","published-online":{"date-parts":[[2023,5,13]]},"reference":[{"key":"2023070505015936600_B1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan MicroRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"2023070505015936600_B2","first-page":"1","article-title":"The role of MicroRNAs in human cancer","volume":"1","author":"Peng","year":"2016","journal-title":"Signal Transduct. 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