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One utility of these resources is to examine the expression of a single gene across all cell types, tissues and cell lines in each atlas. However, there is currently no centralized place that integrates data from several atlases to provide this type of data in a uniform format for visualization, analysis and\u00a0download, and via an\u00a0application programming interface. To address this need, GeneRanger is a web server that provides access to processed data about gene and protein expression across normal human cell types, tissues and cell lines from several atlases. At the same time, TargetRanger is a related web server that takes as input RNA-seq data from profiled human cells and tissues, and then compares the uploaded input data to expression levels across the atlases to identify genes that are highly expressed in the input and lowly expressed across normal human cell types and tissues. Identified targets can be filtered by transmembrane or secreted proteins. The results from GeneRanger and TargetRanger are visualized as box and scatter plots, and as interactive tables. GeneRanger and TargetRanger are available from https:\/\/generanger.maayanlab.cloud and https:\/\/targetranger.maayanlab.cloud, respectively.<\/jats:p>","DOI":"10.1093\/nar\/gkad399","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T15:50:15Z","timestamp":1683820215000},"page":"W213-W224","source":"Crossref","is-referenced-by-count":11,"title":["GeneRanger and TargetRanger: processed gene and protein expression levels across cells and tissues for target discovery"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9727-559X","authenticated-orcid":false,"given":"Giacomo\u00a0B","family":"Marino","sequence":"first","affiliation":[{"name":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , New York, NY 10029 , USA"}]},{"given":"Michael","family":"Ngai","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , New York, NY 10029 , USA"}]},{"given":"Daniel\u00a0J B","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , New York, NY 10029 , USA"}]},{"given":"Reid\u00a0H","family":"Fleishman","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , New York, NY 10029 , USA"}]},{"given":"Eden\u00a0Z","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , New York, NY 10029 , USA"}]},{"given":"Zhuorui","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , New York, NY 10029 , USA"}]},{"given":"Nasheath","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , New York, NY 10029 , USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6904-1017","authenticated-orcid":false,"given":"Avi","family":"Ma\u2019ayan","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai , New York, NY 10029 , USA"}]}],"member":"286","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"2023070504575857900_B1","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The Genotype-Tissue Expression (GTEx) project","volume":"45","author":"GTEx Consortium","year":"2013","journal-title":"Nat. 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