{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:42:23Z","timestamp":1762609343876,"version":"3.37.3"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61872117","31825008","31422014"],"award-info":[{"award-number":["61872117","31825008","31422014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tencent Foundation through the XPLORER PRIZE and the New Cornerstone Science Foundation"},{"name":"Heilongjiang Touyan Team","award":["HITTY-20190034"],"award-info":[{"award-number":["HITTY-20190034"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The CRISPR-Cas system is a highly adaptive and RNA-guided immune system found in bacteria and archaea, which has applications as a genome editing tool and is a valuable system for studying the co-evolutionary dynamics of bacteriophage interactions. Here introduces CRISPRimmunity, a new web server designed for Acr prediction, identification of novel class 2 CRISPR-Cas loci, and dissection of key CRISPR-associated molecular events. CRISPRimmunity is built on a suite of CRISPR-oriented databases providing a comprehensive co-evolutionary perspective of the CRISPR-Cas and anti-CRISPR\u00a0systems. The platform achieved a high prediction accuracy of 0.997 for Acr prediction when tested on a dataset of 99 experimentally validated Acrs and 676 non-Acrs, outperforming other existing prediction tools. Some of the newly identified class 2 CRISPR-Cas loci using CRISPRimmunity have been experimentally validated for cleavage activity in vitro. CRISPRimmunity offers the catalogues of pre-identified CRISPR systems to browse and query, the collected resources or databases to download, a well-designed graphical interface, a detailed tutorial, multi-faceted information, and exportable results in machine-readable formats, making it easy to use and facilitating future experimental design and further data mining. The platform is available at http:\/\/www.microbiome-bigdata.com\/CRISPRimmunity. Moreover, the source code for batch analysis are published on Github (https:\/\/github.com\/HIT-ImmunologyLab\/CRISPRimmunity).<\/jats:p>","DOI":"10.1093\/nar\/gkad425","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T19:33:17Z","timestamp":1684783997000},"page":"W93-W107","source":"Crossref","is-referenced-by-count":23,"title":["CRISPRimmunity: an interactive web server for CRISPR-associated Important Molecular events and Modulators Used in geNome edIting Tool identifYing"],"prefix":"10.1093","volume":"51","author":[{"given":"Fengxia","family":"Zhou","sequence":"first","affiliation":[{"name":"HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology , Harbin \u00a0150080, China"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9829-2028","authenticated-orcid":false,"given":"Xiaorong","family":"Yu","sequence":"additional","affiliation":[{"name":"HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology , Harbin \u00a0150080, China"}]},{"given":"Rui","family":"Gan","sequence":"additional","affiliation":[{"name":"Changping Laboratory , Yard 28, Science Park Road, Changping District, Beijing 102200, China"}]},{"given":"Kuan","family":"Ren","sequence":"additional","affiliation":[{"name":"HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology , Harbin \u00a0150080, China"}]},{"given":"Chuangeng","family":"Chen","sequence":"additional","affiliation":[{"name":"HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology , Harbin \u00a0150080, China"}]},{"given":"Chunyan","family":"Ren","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Boston Children's Hospital, Harvard Medical School , Boston, MA 02115, USA"}]},{"given":"Meng","family":"Cui","sequence":"additional","affiliation":[{"name":"HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology , Harbin \u00a0150080, China"}]},{"given":"Yuchen","family":"Liu","sequence":"additional","affiliation":[{"name":"HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology , Harbin \u00a0150080, China"}]},{"given":"Yiyang","family":"Gao","sequence":"additional","affiliation":[{"name":"HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology , Harbin \u00a0150080, China"}]},{"given":"Shouyu","family":"Wang","sequence":"additional","affiliation":[{"name":"HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology , Harbin \u00a0150080, China"}]},{"given":"Mingyu","family":"Yin","sequence":"additional","affiliation":[{"name":"HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology , Harbin \u00a0150080, China"}]},{"given":"Tengjin","family":"Huang","sequence":"additional","affiliation":[{"name":"HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology , Harbin \u00a0150080, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8201-9391","authenticated-orcid":false,"given":"Zhiwei","family":"Huang","sequence":"additional","affiliation":[{"name":"HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology , Harbin \u00a0150080, China"},{"name":"Westlake Center for Genome Editing, Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University , Hangzhou, Zhejiang 310024, China"},{"name":"New Cornerstone Science Laboratory , Shenzhen 518054, China"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology , Harbin \u00a0150080, China"},{"name":"Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences , Hefei 230031, China"}]}],"member":"286","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"2023070505000010100_B1","doi-asserted-by":"crossref","first-page":"eadd8643","DOI":"10.1126\/science.add8643","article-title":"CRISPR technology: A decade of genome editing is onlythe beginning","volume":"379","author":"Wang","year":"2023","journal-title":"Science"},{"key":"2023070505000010100_B2","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1126\/science.aam9321","article-title":"Nucleic acid detection with CRISPR-Cas13a\/C2c2","volume":"356","author":"Gootenberg","year":"2017","journal-title":"Science"},{"key":"2023070505000010100_B3","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1038\/s41596-019-0210-2","article-title":"SHERLOCK: nucleic acid detection with CRISPR nucleases","volume":"14","author":"Kellner","year":"2019","journal-title":"Nat. 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