{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:25:18Z","timestamp":1779323118171,"version":"3.51.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"suppl_1","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"vor","delay-in-days":2898,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1093\/nar\/gkn823","type":"journal-article","created":{"date-parts":[[2008,10,28]],"date-time":"2008-10-28T21:53:27Z","timestamp":1225230807000},"page":"D933-D937","source":"Crossref","is-referenced-by-count":753,"title":["APD2: the updated antimicrobial peptide database and its application in peptide design"],"prefix":"10.1093","volume":"37","author":[{"given":"Guangshun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,10,28]]},"reference":[{"key":"key\n\t\t\t\t20170510093923_B1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/415389a","article-title":"Antimicrobial peptides of multicellular organisms","volume":"415","author":"Zasloff","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170510093923_B2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1046\/j.1365-2796.2003.01228.x","article-title":"Antibacterial peptides: basic facts and emerging concepts","volume":"254","author":"Boman","year":"2003","journal-title":"J. Intern. Med."},{"key":"key\n\t\t\t\t20170510093923_B3","first-page":"11","article-title":"Antimicrobial peptides in human skin disease","volume":"18","author":"Yamasaki","year":"2008","journal-title":"Eur. J. Dermatol."},{"key":"key\n\t\t\t\t20170510093923_B4","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/nbt1267","article-title":"Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies","volume":"24","author":"Hancock","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t20170510093923_B5","doi-asserted-by":"crossref","first-page":"9920","DOI":"10.1021\/bi700720e","article-title":"Retrocyclin-2: structural analysis of a potent anti-HIV theta-defensin","volume":"46","author":"Daly","year":"2007","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170510093923_B6","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gkh025","article-title":"APD: the Antimicrobial peptide database","volume":"32","author":"Wang","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510093923_B7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2174\/0929866023408986","article-title":"Synthetic antimicrobial peptide database","volume":"9","author":"Wade","year":"2002","journal-title":"Protein Pept. Lett."},{"key":"key\n\t\t\t\t20170510093923_B8","doi-asserted-by":"crossref","first-page":"D586","DOI":"10.1093\/nar\/gkh032","article-title":"ANTIMIC: a database of antimicrobial sequences","volume":"32","author":"Brahmachary","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510093923_B9","doi-asserted-by":"crossref","first-page":"D593","DOI":"10.1093\/nar\/gkh077","article-title":"The Peptaibol Database: a database for sequences and structures of naturally occurring peptaibols","volume":"32","author":"Whitmore","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510093923_B10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.dci.2005.04.003","article-title":"PenBase, the shrimp antimicrobial peptide penaeidin database: sequence-based classification and recommended nomenclature","volume":"30","author":"Gueguen","year":"2006","journal-title":"Dev. Comp. Immunol."},{"key":"key\n\t\t\t\t20170510093923_B11","doi-asserted-by":"crossref","first-page":"D265","DOI":"10.1093\/nar\/gkl866","article-title":"Defensins knowledgebase: a manually curated database and information source focused on the defensins family of antimicrobial peptides","volume":"35","author":"Seebah","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510093923_B12","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/bioinformatics\/btm068","article-title":"AMPer: a database and an automated discovery tool for antimicrobial peptides","volume":"23","author":"Fjell","year":"2007","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170510093923_B13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1471-2180-7-89","article-title":"BACTIBASE: a new web-accessible database for bacteriocin characterization","volume":"7","author":"Hammami","year":"2007","journal-title":"BMC Microbiol."},{"key":"key\n\t\t\t\t20170510093923_B14","doi-asserted-by":"crossref","first-page":"D206","DOI":"10.1093\/nar\/gkm953","article-title":"Cybase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineering","volume":"36","author":"Wang","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510093923_B15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/092986607779117182","article-title":"Tool developments for structure-function studies of host defense peptides","volume":"14","author":"Wang","year":"2007","journal-title":"Protein Pept. Lett."},{"key":"key\n\t\t\t\t20170510093923_B16","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nature05233","article-title":"A linguistic model for the rational design of antimicrobial peptides","volume":"443","author":"Loose","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170510093923_B17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/1471-2105-8-263","article-title":"Analysis and prediction of antibacterial peptides","volume":"8","author":"Lata","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20170510093923_B18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.bbamem.2007.11.008","article-title":"Studies on anticancer activities of antimicrobial peptides","volume":"1778","author":"Hoskin","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170510093923_B19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-0897.2007.00561.x","article-title":"Antimicrobial polypeptides are key anti-HIV-1 effector molecules of cervicovaginal host defense","volume":"59","author":"Cole","year":"2008","journal-title":"Am. J. Reprod. Immunol."},{"key":"key\n\t\t\t\t20170510093923_B20","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1128\/AAC.00452-08","article-title":"Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins","volume":"52","author":"Wang","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"key\n\t\t\t\t20170510093923_B21","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.peptides.2008.04.016","article-title":"A proposed nomenclature for antimicrobial peptides from frogs of the genus Leptodactylus","volume":"29","author":"Conlon","year":"2008","journal-title":"Peptides"},{"key":"key\n\t\t\t\t20170510093923_B22","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2008.06.017","article-title":"A consistent nomenclature of antimicrobial peptides isolated from frogs of the subfamily Phyllomedusinae","author":"Amiche","year":"2008","journal-title":"Peptides"},{"key":"key\n\t\t\t\t20170510093923_B23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0005-2736(99)00198-4","article-title":"Diversity of antimicrobial peptides and their mechanisms of action","volume":"1462","author":"Epand","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170510093923_B24","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2174\/138527206776055259","article-title":"Structural biology of antimicrobial peptides by NMR spectroscopy","volume":"10","author":"Wang","year":"2006","journal-title":"Curr. Org. Chem."},{"key":"key\n\t\t\t\t20170510093923_B25","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510093923_B26","doi-asserted-by":"crossref","first-page":"32637","DOI":"10.1074\/jbc.M805533200","article-title":"Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles","volume":"283","author":"Wang","year":"2008","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170510093923_B27","doi-asserted-by":"crossref","first-page":"5803","DOI":"10.1074\/jbc.M410116200","article-title":"Correlation of three-dimensional structures with the antibacterial activity of a group of peptides designed based on a nontoxic bacterial membrane anchor","volume":"280","author":"Wang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170510093923_B28","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.1021\/ja0584875","article-title":"Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region","volume":"128","author":"Li","year":"2006","journal-title":"J. Am. Chem. Soc."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/37\/suppl_1\/D933\/16758395\/gkn823.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T10:40:23Z","timestamp":1522665623000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkn823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,28]]},"references-count":28,"journal-issue":{"issue":"suppl_1","published-online":{"date-parts":[[2008,10,28]]},"published-print":{"date-parts":[[2009,1]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkn823","relation":{},"ISSN":["1362-4962","0305-1048"],"issn-type":[{"value":"1362-4962","type":"electronic"},{"value":"0305-1048","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10,28]]}}}