{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:23:38Z","timestamp":1768523018940,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"suppl_1","license":[{"start":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T00:00:00Z","timestamp":1494374400000},"content-version":"vor","delay-in-days":2743,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1093\/nar\/gkp968","type":"journal-article","created":{"date-parts":[[2009,11,6]],"date-time":"2009-11-06T02:48:33Z","timestamp":1257475713000},"page":"D149-D154","source":"Crossref","is-referenced-by-count":79,"title":["HHMD: the human histone modification database"],"prefix":"10.1093","volume":"38","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[]},{"given":"Jie","family":"Lv","sequence":"additional","affiliation":[]},{"given":"Hongbo","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Jiang","family":"Zhu","sequence":"additional","affiliation":[]},{"given":"Jianzhong","family":"Su","sequence":"additional","affiliation":[]},{"given":"Qiong","family":"Wu","sequence":"additional","affiliation":[]},{"given":"Yunfeng","family":"Qi","sequence":"additional","affiliation":[]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2009,11,5]]},"reference":[{"key":"key\n\t\t\t\t20170510130713_B1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.str.2008.01.004","article-title":"Mammalian DNA methyltransferases: a structural perspective","volume":"16","author":"Cheng","year":"2008","journal-title":"Structure"},{"key":"key\n\t\t\t\t20170510130713_B2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.gde.2009.02.001","article-title":"Characterization of human epigenomes","volume":"19","author":"Wang","year":"2009","journal-title":"Curr. Opin. Genet. Dev."},{"key":"key\n\t\t\t\t20170510130713_B3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/gb-2005-6-6-113","article-title":"Histone modifications: from genome-wide maps to functional insights","volume":"6","author":"van Leeuwen","year":"2005","journal-title":"Genome Biol."},{"key":"key\n\t\t\t\t20170510130713_B4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0959-437X(02)00287-3","article-title":"Histone methylation in transcriptional control","volume":"12","author":"Kouzarides","year":"2002","journal-title":"Curr. Opin. Genet. Dev."},{"key":"key\n\t\t\t\t20170510130713_B5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nrg2270","article-title":"Genome-wide approaches to studying chromatin modifications","volume":"9","author":"Schones","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"key\n\t\t\t\t20170510130713_B6","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nrg2005","article-title":"Cancer epigenomics: DNA methylomes and histone-modification maps","volume":"8","author":"Esteller","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"key\n\t\t\t\t20170510130713_B7","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/ng.159","article-title":"Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation","volume":"40","author":"Kondo","year":"2008","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170510130713_B8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/bioinformatics\/btm546","article-title":"Computational epigenetics","volume":"24","author":"Bock","year":"2008","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170510130713_B9","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1093\/bioinformatics\/btm236","article-title":"ChromatinDB: a database of genome-wide histone modification patterns for Saccharomyces cerevisiae","volume":"23","author":"O'Connor","year":"2007","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170510130713_B10","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/nar\/26.1.372","article-title":"Histone Sequence Database: new histone fold family members","volume":"26","author":"Baxevanis","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510130713_B11","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/nar\/28.1.320","article-title":"The histone database: a comprehensive WWW resource for histones and histone fold-containing proteins","volume":"28","author":"Sullivan","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510130713_B12","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/prot.20814","article-title":"The Histone Database: a comprehensive resource for histones and histone fold-containing proteins","volume":"62","author":"Marino-Ramirez","year":"2006","journal-title":"Proteins"},{"key":"key\n\t\t\t\t20170510130713_B13","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1074\/mcp.M900030-MCP200","article-title":"SysPTM \u2013 a systematic resource for proteomic research of post-translational modifications","volume":"8","author":"Li","year":"2009","journal-title":"Mol. Cell Proteomics"},{"key":"key\n\t\t\t\t20170510130713_B14","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1101\/gr.083402.108","article-title":"HistoneHits: a database for histone mutations and their phenotypes","volume":"19","author":"Huang","year":"2009","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20170510130713_B15","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature07385","article-title":"Comprehensive genomic characterization defines human glioblastoma genes and core pathways","volume":"455","author":"Cancer Genome Atlas Research Network","year":"2008","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170510130713_B16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-2105-9-22","article-title":"MeInfoText: associated gene methylation and cancer information from text mining","volume":"9","author":"Fang","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20170510130713_B17","doi-asserted-by":"crossref","first-page":"D842","DOI":"10.1093\/nar\/gkm788","article-title":"PubMeth: a cancer methylation database combining text-mining and expert annotation","volume":"36","author":"Ongenaert","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20170510130713_B18","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.cell.2007.01.029","article-title":"The epigenomics of cancer","volume":"128","author":"Jones","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510130713_B19","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/j.1349-7006.2009.01095.x","article-title":"Cancer epigenomics: implications of DNA methylation in personalized cancer therapy","volume":"100","author":"Toyota","year":"2009","journal-title":"Cancer Sci."},{"key":"key\n\t\t\t\t20170510130713_B20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.med.59.061606.095816","article-title":"Cancer epigenetics: modifications, screening, and therapy","volume":"59","author":"Gal-Yam","year":"2008","journal-title":"Annu. Rev. Med."},{"key":"key\n\t\t\t\t20170510130713_B21","doi-asserted-by":"crossref","first-page":"D32","DOI":"10.1093\/nar\/gkn721","article-title":"NCBI Reference Sequences: current status, policy and new initiatives","volume":"37","author":"Pruitt","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510130713_B22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-1-60327-192-9_10","article-title":"Methylation analysis by DNA immunoprecipitation (MeDIP)","volume":"556","author":"Vucic","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"key\n\t\t\t\t20170510130713_B23","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1101\/gr.077479.108","article-title":"An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs)","volume":"18","author":"Rakyan","year":"2008","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20170510130713_B24","doi-asserted-by":"crossref","first-page":"D26","DOI":"10.1093\/nar\/gkl993","article-title":"Entrez Gene: gene-centered information at NCBI","volume":"35","author":"Maglott","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510130713_B25","doi-asserted-by":"crossref","first-page":"D755","DOI":"10.1093\/nar\/gkn875","article-title":"The UCSC enome Browser Database: update 2009","volume":"37","author":"Kuhn","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510130713_B26","doi-asserted-by":"crossref","first-page":"D396","DOI":"10.1093\/nar\/gkn803","article-title":"The GOA database in 2009\u2014an integrated Gene Ontology Annotation resource","volume":"37","author":"Barrell","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510130713_B27","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkm882","article-title":"KEGG for linking genomes to life and the environment","volume":"36","author":"Kanehisa","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510130713_B28","doi-asserted-by":"crossref","first-page":"D61","DOI":"10.1093\/nar\/gkl842","article-title":"NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins","volume":"35","author":"Pruitt","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510130713_B29","doi-asserted-by":"crossref","first-page":"D793","DOI":"10.1093\/nar\/gkn665","article-title":"McKusick's; online Mendelian inheritance in man (OMIM)","volume":"37","author":"Amberger","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510130713_B30","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.274.5287.540","article-title":"A gene map of the human genome","volume":"274","author":"Schuler","year":"1996","journal-title":"Science"},{"key":"key\n\t\t\t\t20170510130713_B31","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/nar\/27.1.284","article-title":"Database of protein sequence alignments: PIR-ALN","volume":"27","author":"Srinivasarao","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510130713_B32","doi-asserted-by":"crossref","first-page":"D690","DOI":"10.1093\/nar\/gkn828","article-title":"Ensembl 2009","volume":"37","author":"Hubbard","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510130713_B33","doi-asserted-by":"crossref","first-page":"D836","DOI":"10.1093\/nar\/gkm730","article-title":"MethyCancer: the database of human DNA methylation and cancer","volume":"36","author":"He","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510130713_B34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0955-0674(03)00013-9","article-title":"Histone and chromatin cross-talk","volume":"15","author":"Fischle","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"key\n\t\t\t\t20170510130713_B35","first-page":"468","article-title":"How does the histone code work? Biochem","volume":"83","author":"Cosgrove","year":"2005","journal-title":"Cell Biol."},{"key":"key\n\t\t\t\t20170510130713_B36","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.stem.2007.08.004","article-title":"Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells","volume":"1","author":"Zhao","year":"2007","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20170510130713_B37","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cell.2006.02.041","article-title":"A bivalent chromatin structure marks key developmental genes in embryonic stem cells","volume":"125","author":"Bernstein","year":"2006","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510130713_B38","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2007.05.009","article-title":"High-resolution profiling of histone methylations in the human genome","volume":"129","author":"Barski","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510130713_B39","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ng.154","article-title":"Combinatorial patterns of histone acetylations and methylations in the human genome","volume":"40","author":"Wang","year":"2008","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170510130713_B40","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0955-0674(02)00335-6","article-title":"The many faces of histone lysine methylation","volume":"14","author":"Lachner","year":"2002","journal-title":"Curr. Opin. Cell Biol."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/38\/suppl_1\/D149\/16772668\/gkp968.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T14:41:10Z","timestamp":1522680070000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkp968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,5]]},"references-count":40,"journal-issue":{"issue":"suppl_1","published-online":{"date-parts":[[2009,11,5]]},"published-print":{"date-parts":[[2010,1]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkp968","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,5]]}}}